tetano
Editor, Senior Moderator
Neurol Sci
. 2020 Oct 20.
doi: 10.1007/s10072-020-04837-0. Online ahead of print.
Update on cerebrovascular manifestations of COVID-19
Reza Naeimi[SUP] 1 [/SUP], Maryam Ghasemi-Kasman[SUP] 2 3 [/SUP]
Affiliations
Abstract
The novel member of coronaviruses family, severe acute respiratory coronavirus-2 (SARS-CoV-2), with high structural homology to SARS-CoV and Middle East respiratory syndrome-related coronavirus (MERS) has spread rapidly with about 20 million cases infection and over 700,000 deaths. SARS-CoV-2 has been emerged as a worldwide disaster due to non-specific few respiratory and gastrointestinal manifestations at the onset of disease as well as long incubation period. Surprisingly, not only respiratory failure but also the underlying coagulation disorder and neurovascular involvement worsen the clinical outcome of infected patients. In this review article, we describe the probable mechanisms of SARS-CoV-2 infection and stroke occurrence. We will also discuss the cerebrovascular events following SARS-CoV-2 infection, the recommended therapies, and future prospects to better manage these patients in coronavirus disease 2019 (COVID-19) outbreak.
Keywords: Anticoagulative therapies; COVID-19; Coagulation; Coronavirus; SARS-CoV-2; Stroke.
. 2020 Oct 20.
doi: 10.1007/s10072-020-04837-0. Online ahead of print.
Update on cerebrovascular manifestations of COVID-19
Reza Naeimi[SUP] 1 [/SUP], Maryam Ghasemi-Kasman[SUP] 2 3 [/SUP]
Affiliations
- PMID: 33083934
- DOI: 10.1007/s10072-020-04837-0
Abstract
The novel member of coronaviruses family, severe acute respiratory coronavirus-2 (SARS-CoV-2), with high structural homology to SARS-CoV and Middle East respiratory syndrome-related coronavirus (MERS) has spread rapidly with about 20 million cases infection and over 700,000 deaths. SARS-CoV-2 has been emerged as a worldwide disaster due to non-specific few respiratory and gastrointestinal manifestations at the onset of disease as well as long incubation period. Surprisingly, not only respiratory failure but also the underlying coagulation disorder and neurovascular involvement worsen the clinical outcome of infected patients. In this review article, we describe the probable mechanisms of SARS-CoV-2 infection and stroke occurrence. We will also discuss the cerebrovascular events following SARS-CoV-2 infection, the recommended therapies, and future prospects to better manage these patients in coronavirus disease 2019 (COVID-19) outbreak.
Keywords: Anticoagulative therapies; COVID-19; Coagulation; Coronavirus; SARS-CoV-2; Stroke.