tetano
Editor, Senior Moderator
Neurol Sci
. 2021 Jan 11.
doi: 10.1007/s10072-020-04964-8. Online ahead of print.
Neurological manifestations of coronavirus disease 2019: exploring past to understand present
Ishita Desai[SUP] 1 [/SUP], Rajat Manchanda[SUP] 1 [/SUP], Niraj Kumar[SUP] 2 [/SUP], Ashutosh Tiwari[SUP] 1 [/SUP], Mritunjai Kumar[SUP] 1 [/SUP]
Affiliations
Abstract
SARS-CoV-2 infection, resulting in Coronavirus disease 2019 (COVID-19), has significantly affected the entire world. It was labelled a pandemic by World Health Organization. Although it commonly produces respiratory symptoms, neurological features have been described. Neurological manifestations may vary from non-specific symptoms such as headache, dizziness, myalgia and/or fatigue, olfactory or taste dysfunction to specific syndromes including meningitis, stroke, acute transverse myelitis and Guillain-Barre syndrome. This review describes potential pathogenetic mechanisms and neurological manifestations of COVID-19 along with its management. Considering structural and pathogenetic similarity of SARS-CoV-2 with SARS-CoV and MERS viruses, we compared their neurological manifestations and mentioned few features expected in COVID-19 in future. Interestingly, many COVID-19 cases may present with pure neurological manifestations at onset with non-neurological features manifesting few days later and we propose the term "Neuro-COVID syndrome" for such cases. Awareness of neurological manifestations may facilitate its management and improve outcome in such patients.
Keywords: COVID-19; Coronavirus; Neuro-COVID syndrome; SARS-CoV-2; neuroinvasion; neurological manifestations.
. 2021 Jan 11.
doi: 10.1007/s10072-020-04964-8. Online ahead of print.
Neurological manifestations of coronavirus disease 2019: exploring past to understand present
Ishita Desai[SUP] 1 [/SUP], Rajat Manchanda[SUP] 1 [/SUP], Niraj Kumar[SUP] 2 [/SUP], Ashutosh Tiwari[SUP] 1 [/SUP], Mritunjai Kumar[SUP] 1 [/SUP]
Affiliations
- PMID: 33428055
- DOI: 10.1007/s10072-020-04964-8
Abstract
SARS-CoV-2 infection, resulting in Coronavirus disease 2019 (COVID-19), has significantly affected the entire world. It was labelled a pandemic by World Health Organization. Although it commonly produces respiratory symptoms, neurological features have been described. Neurological manifestations may vary from non-specific symptoms such as headache, dizziness, myalgia and/or fatigue, olfactory or taste dysfunction to specific syndromes including meningitis, stroke, acute transverse myelitis and Guillain-Barre syndrome. This review describes potential pathogenetic mechanisms and neurological manifestations of COVID-19 along with its management. Considering structural and pathogenetic similarity of SARS-CoV-2 with SARS-CoV and MERS viruses, we compared their neurological manifestations and mentioned few features expected in COVID-19 in future. Interestingly, many COVID-19 cases may present with pure neurological manifestations at onset with non-neurological features manifesting few days later and we propose the term "Neuro-COVID syndrome" for such cases. Awareness of neurological manifestations may facilitate its management and improve outcome in such patients.
Keywords: COVID-19; Coronavirus; Neuro-COVID syndrome; SARS-CoV-2; neuroinvasion; neurological manifestations.