tetano
Editor, Senior Moderator
Neurohospitalist
. 2022 Apr;12(2):361-365.
doi: 10.1177/19418744211050215. Epub 2021 Dec 31.
Acute Cerebellitis and Myeloradiculitis Associated With SARS-CoV-2 Infection in Common Variable Immunodeficiency-A Case Report
Hernan Nicolas Lemus[SUP] 1 [/SUP], Miryam Alkayyali[SUP] 1 [/SUP], Eonjung Kim[SUP] 1 [/SUP], Charlotte Cunnigham-Rundles[SUP] 2 [/SUP], Dewitt Pyburn[SUP] 1 [/SUP], Rory Abrams[SUP] 3 [/SUP]
Affiliations
Abstract
The role of the adaptive immune system in mediating COVID-19 is largely unknown. Therefore, it is difficult to predict the clinical course in patients with common variable immunodeficiency (CVID), a disease characterized by dysfunctional lymphocytes and impaired antibody production. We report a case of SARS-CoV-2 infection presenting as isolated neurological symptoms in a patient with CVID. The patient subsequently improved following steroids, intravenous immunoglobulin, and convalescent plasma (CP). The latter has been shown to be safe and efficacious in treating COVID-19 in patients with primary immunodeficiency. Recent data suggest that the mechanism of CNS injury in COVID-19 may be due to immunological dysregulation rather than direct viral-mediated injury. This case exemplifies the complex interaction between the brain, the immune system, and the SARS-CoV-2 virus.
Keywords: COVID-19; cerebellar; coronavirus; immunocompromised; radiculopathy.
. 2022 Apr;12(2):361-365.
doi: 10.1177/19418744211050215. Epub 2021 Dec 31.
Acute Cerebellitis and Myeloradiculitis Associated With SARS-CoV-2 Infection in Common Variable Immunodeficiency-A Case Report
Hernan Nicolas Lemus[SUP] 1 [/SUP], Miryam Alkayyali[SUP] 1 [/SUP], Eonjung Kim[SUP] 1 [/SUP], Charlotte Cunnigham-Rundles[SUP] 2 [/SUP], Dewitt Pyburn[SUP] 1 [/SUP], Rory Abrams[SUP] 3 [/SUP]
Affiliations
- PMID: 35419133
- PMCID: PMC8995593 (available on 2023-04-01)
- DOI: 10.1177/19418744211050215
Abstract
The role of the adaptive immune system in mediating COVID-19 is largely unknown. Therefore, it is difficult to predict the clinical course in patients with common variable immunodeficiency (CVID), a disease characterized by dysfunctional lymphocytes and impaired antibody production. We report a case of SARS-CoV-2 infection presenting as isolated neurological symptoms in a patient with CVID. The patient subsequently improved following steroids, intravenous immunoglobulin, and convalescent plasma (CP). The latter has been shown to be safe and efficacious in treating COVID-19 in patients with primary immunodeficiency. Recent data suggest that the mechanism of CNS injury in COVID-19 may be due to immunological dysregulation rather than direct viral-mediated injury. This case exemplifies the complex interaction between the brain, the immune system, and the SARS-CoV-2 virus.
Keywords: COVID-19; cerebellar; coronavirus; immunocompromised; radiculopathy.