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Nepal: First cases of Creutzfeldt-Jakob disease (CJD) reported in 2019-2021

Emily

Editor, Senior Moderator
https://onlinelibrary.wiley.com/doi/10.1002/ccr3.2609

Kharel, H, Adhikari, P, Pokhrel, NB, Kharel, Z, Nepal, G. The first reported case of Creutzfeldt-Jakob disease from Nepal. Clin Case Rep. 2020; 8: 198– 202. https://doi.org/10.1002/ccr3.2609
...
We report a rare case of probable sporadic Creutzfeldt-Jakob disease (CJD) in a 58-year-old lady who presented initially with treatment-resistant depression. Imaging revealed subtle basal ganglia changes. The electroencephalogram showed periodic 1 Hz biphasic discharges typical of CJD. Supportive care was provided but her condition rapidly worsened.


https://onlinelibrary.wiley.com/doi/10.1002/ccr3.4804

Neupane, D, Gupta, PK, Subedi, SS, Gupta, D, Chhetri, S. A rare case of Creutzfeldt-Jakob disease reported from Nepal. Clin Case Rep. 2021; 9:e04804. https://doi.org/10.1002/ccr3.4804
...
We report a rare case of probable Creutzfeldt-Jakob disease (CJD) in a 65-year-old man, probably the second case in Nepal, who initially presented with progressively increasing low mood with catatonia along with rapidly progressive dementia and features of upper motor neuron lesions. The first case of CJD from Nepal being reported by Kharel et al[SUP]1[/SUP]in 2019. Magnetic resonance imaging of brain revealed confluent areas of T2 and fluid-attenuated inversion recovery (FLAIR) high signal intensity in bilateral fronto-parietal deep white matter. The electroencephalogram showed bilaterally synchronous periodic pattern of bi- or triphasic sharp waves of 1 Hz. The patient expired at 1.5 months of diagnosis...
 
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