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NEJM Evid . The Persistence of SARS-CoV-2 and Its Role in Long Covid

tetano

Editor, Senior Moderator
NEJM Evid


. 2023 Sep;2(9):EVIDe2300165.
doi: 10.1056/EVIDe2300165. Epub 2023 Aug 22. The Persistence of SARS-CoV-2 and Its Role in Long Covid

Katie E Lineburg[SUP] 1 [/SUP], Corey Smith[SUP] 1 [/SUP]



Affiliations
Abstract

Postacute sequelae of coronavirus disease 2019 (PASC), more commonly known as long Covid, manifests as ongoing symptoms in various organs of the body more than 4 weeks after the resolution of acute Covid-19.[SUP]1[/SUP] A prevalent symptom of PASC is an ongoing loss of taste, but additional persisting symptoms can include neurologic, gastrointestinal, kidney, lung, or heart dysfunction.[SUP]1,2[/SUP] There are two broad mechanisms that are thought to underpin the ongoing complications associated with PASC: dysregulated production of inflammatory cytokines and the persistence of virus.[SUP]3[/SUP].


 
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