tetano
Editor, Senior Moderator
NEJM Evid
. 2026 Mar 3:EVIDpha2600007.
doi: 10.1056/EVIDpha2600007. Online ahead of print.
Antibodies Elicited by the 2025-2026 Influenza Vaccine
Jiaojiao Liu[SUP] 1 [/SUP], Shuk Hang Li[SUP] 1 [/SUP], Naiqing Ye[SUP] 1 [/SUP], Tachianna Griffiths[SUP] 1 [/SUP], Elizabeth M Drapeau[SUP] 1 [/SUP], Reilly K Atkinson[SUP] 1 [/SUP], Ronald G Collman[SUP] 2 [/SUP], Scott E Hensley[SUP] 1 [/SUP]
Affiliations
AbstractA new H3N2 variant (named subclade K) possesses several key hemagglutinin substitutions and is circulating widely during the 2025-2026 influenza season. We sought to determine whether the 2025-2026 seasonal influenza vaccine elicits antibodies in humans that recognize this variant. We found that H3N2 subclade K viruses are antigenically advanced; however, the 2025-2026 seasonal influenza vaccine elicited antibodies in many individuals that efficiently recognized these viruses. Thus, the current seasonal influenza vaccine likely will be partially effective at preventing illness associated with H3N2 subclade K virus infections.
. 2026 Mar 3:EVIDpha2600007.
doi: 10.1056/EVIDpha2600007. Online ahead of print.
Antibodies Elicited by the 2025-2026 Influenza Vaccine
Jiaojiao Liu[SUP] 1 [/SUP], Shuk Hang Li[SUP] 1 [/SUP], Naiqing Ye[SUP] 1 [/SUP], Tachianna Griffiths[SUP] 1 [/SUP], Elizabeth M Drapeau[SUP] 1 [/SUP], Reilly K Atkinson[SUP] 1 [/SUP], Ronald G Collman[SUP] 2 [/SUP], Scott E Hensley[SUP] 1 [/SUP]
Affiliations
- PMID: 41774915
- DOI: 10.1056/EVIDpha2600007
AbstractA new H3N2 variant (named subclade K) possesses several key hemagglutinin substitutions and is circulating widely during the 2025-2026 influenza season. We sought to determine whether the 2025-2026 seasonal influenza vaccine elicits antibodies in humans that recognize this variant. We found that H3N2 subclade K viruses are antigenically advanced; however, the 2025-2026 seasonal influenza vaccine elicited antibodies in many individuals that efficiently recognized these viruses. Thus, the current seasonal influenza vaccine likely will be partially effective at preventing illness associated with H3N2 subclade K virus infections.