sharon sanders
Editor-in-Chief & President
It appears that 19 of the 29 people in this study with oseltamivir resistant A/H1N1pdm09 had no known links to each other. i.e. Possible community spread of oseltamivir resistant A/H1N1pdm09.
Community Transmission of Oseltamivir-Resistant A(H1N1)pdm09 Influenza
N Engl J Med 2011; 365:2541-2542
December 29, 2011
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A fluorescence-based neuraminidase inhibition assay5 of the H275Y isolates showed that the IC50 value (the concentration of drug required to inhibit neuraminidase activity by 50%) was 513 times higher for oseltamivir and 80 times higher for peramivir than the IC50 values associated with wild-type strains.
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Hospital records and interviews with patients and general practitioners revealed that only 1 of the 29 patients with resistant influenza had received oseltamivir before the influenza specimen collection
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Four households had 2 affected patients each, and 2 other patients shared a short car journey. The remaining patients had no known epidemiologic link with the other patients with oseltamivir-resistant influenza described here.
http://www.nejm.org/doi/full/10.1056/NEJMc1111078
Community Transmission of Oseltamivir-Resistant A(H1N1)pdm09 Influenza
N Engl J Med 2011; 365:2541-2542
December 29, 2011
snip
A fluorescence-based neuraminidase inhibition assay5 of the H275Y isolates showed that the IC50 value (the concentration of drug required to inhibit neuraminidase activity by 50%) was 513 times higher for oseltamivir and 80 times higher for peramivir than the IC50 values associated with wild-type strains.
snip
Hospital records and interviews with patients and general practitioners revealed that only 1 of the 29 patients with resistant influenza had received oseltamivir before the influenza specimen collection
snip
Four households had 2 affected patients each, and 2 other patients shared a short car journey. The remaining patients had no known epidemiologic link with the other patients with oseltamivir-resistant influenza described here.
http://www.nejm.org/doi/full/10.1056/NEJMc1111078