tetano
Editor, Senior Moderator
Dokl Biochem Biophys. 2017 Mar;473(1):122-127. doi: 10.1134/S1607672917020090. Epub 2017 May 17.
[h=1]Negative-sense virion RNA of segment 8 (NS) of influenza a virus is able to translate in vitro a new viral protein.[/h] Zhirnov OP[SUP]1[/SUP], Akulich KA[SUP]2[/SUP], Lipatova AV[SUP]3[/SUP], Usachev EV[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] It was shown that full-length virion RNA of segment 8 of influenza virus A/Aichi/2/68 (H3N2) can initiate the synthesis of two major polypeptides with molecular weights of 23 and 13 kD and a minor polypeptide with a molecular weight of 19 kDa, which specifically reacted with the antibodies to the 30-membered peptide of the central part of the NSP protein of influenza A virus. Thus, the genomic-polarity RNA of segment 8 of influenza virus A has a translational template function. These data provide further confirmation of the concept of the bipolar (ambisens) strategy of functioning of the influenza A virus genome.
PMID: 28510127 DOI: 10.1134/S1607672917020090
[h=1]Negative-sense virion RNA of segment 8 (NS) of influenza a virus is able to translate in vitro a new viral protein.[/h] Zhirnov OP[SUP]1[/SUP], Akulich KA[SUP]2[/SUP], Lipatova AV[SUP]3[/SUP], Usachev EV[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] It was shown that full-length virion RNA of segment 8 of influenza virus A/Aichi/2/68 (H3N2) can initiate the synthesis of two major polypeptides with molecular weights of 23 and 13 kD and a minor polypeptide with a molecular weight of 19 kDa, which specifically reacted with the antibodies to the 30-membered peptide of the central part of the NSP protein of influenza A virus. Thus, the genomic-polarity RNA of segment 8 of influenza virus A has a translational template function. These data provide further confirmation of the concept of the bipolar (ambisens) strategy of functioning of the influenza A virus genome.
PMID: 28510127 DOI: 10.1134/S1607672917020090