tetano
Editor, Senior Moderator
Vaccine. 2016 Dec 30. pii: S0264-410X(16)31071-4. doi: 10.1016/j.vaccine.2016.11.024. [Epub ahead of print]
[h=1]Negative impact of prior influenza vaccination on current influenza vaccination among people infected and not infected in prior season: A test-negative case-control study in Japan.[/h] Saito N[SUP]1[/SUP], Komori K[SUP]2[/SUP], Suzuki M[SUP]3[/SUP], Morimoto K[SUP]3[/SUP], Kishikawa T[SUP]2[/SUP], Yasaka T[SUP]2[/SUP], Ariyoshi K[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Accumulating evidences indicate that repeated influenza vaccination has negative impact on the vaccine effectiveness (VE). However no published studies considered past influenza infection when assessing the VE of repeated vaccination.
[h=4]METHODS:[/h] Prospective surveillance was conducted from 2009 to 2012 at a community hospital on a small island in Japan. The study included all outpatients with an influenza-like illness (ILI) who attended the hospital, and a rapid diagnostic test (RDT) was used to diagnose influenza A/B infection. The VE of trivalent inactivated influenza vaccine (TIV) against medically attended influenza A (MA-fluA) was estimated using a test-negative case-control study design. The influence of TIV in the prior season on VE in the current season was investigated in the context of MA-fluA during the prior season.
[h=4]RESULTS:[/h] During the three influenza seasons, 5838 ILI episodes (4127 subjects) were analysed. Subjects who had an episode of MA-fluA in the prior season were at a significantly lower risk of MA-fluA in the current season (adjusted odds ratio: 0.38, 95% CI: 0.30-0.50). The overall adjusted VE was 28% (95% CI, 14-40). VE was substantially lower in subjects vaccinated in the prior season compared to those who had not been vaccinated in prior season (19%; 95% CI: 0-35 vs 46%; 95% CI: 26-60, test for interaction, P value <0.05). In subjects who did not have MA-fluA in the prior season showed the attenuation of VE due to repeated vaccination (13%; 95% CI: -7 to 30 vs 44%; 95% CI: 24-59, test for interaction, P<0.05). However this effect was not detected in subjects who had contracted MA-fluA in the prior season.
[h=4]CONCLUSIONS:[/h] Negative effects of repeated vaccination were significant among those without history of MA-fluA in the prior season.
Copyright ? 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; Past influenza exposure; Repeated vaccination; Vaccine effectiveness
PMID: 28043738 DOI: 10.1016/j.vaccine.2016.11.024
[PubMed - as supplied by publisher]
[h=1]Negative impact of prior influenza vaccination on current influenza vaccination among people infected and not infected in prior season: A test-negative case-control study in Japan.[/h] Saito N[SUP]1[/SUP], Komori K[SUP]2[/SUP], Suzuki M[SUP]3[/SUP], Morimoto K[SUP]3[/SUP], Kishikawa T[SUP]2[/SUP], Yasaka T[SUP]2[/SUP], Ariyoshi K[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Accumulating evidences indicate that repeated influenza vaccination has negative impact on the vaccine effectiveness (VE). However no published studies considered past influenza infection when assessing the VE of repeated vaccination.
[h=4]METHODS:[/h] Prospective surveillance was conducted from 2009 to 2012 at a community hospital on a small island in Japan. The study included all outpatients with an influenza-like illness (ILI) who attended the hospital, and a rapid diagnostic test (RDT) was used to diagnose influenza A/B infection. The VE of trivalent inactivated influenza vaccine (TIV) against medically attended influenza A (MA-fluA) was estimated using a test-negative case-control study design. The influence of TIV in the prior season on VE in the current season was investigated in the context of MA-fluA during the prior season.
[h=4]RESULTS:[/h] During the three influenza seasons, 5838 ILI episodes (4127 subjects) were analysed. Subjects who had an episode of MA-fluA in the prior season were at a significantly lower risk of MA-fluA in the current season (adjusted odds ratio: 0.38, 95% CI: 0.30-0.50). The overall adjusted VE was 28% (95% CI, 14-40). VE was substantially lower in subjects vaccinated in the prior season compared to those who had not been vaccinated in prior season (19%; 95% CI: 0-35 vs 46%; 95% CI: 26-60, test for interaction, P value <0.05). In subjects who did not have MA-fluA in the prior season showed the attenuation of VE due to repeated vaccination (13%; 95% CI: -7 to 30 vs 44%; 95% CI: 24-59, test for interaction, P<0.05). However this effect was not detected in subjects who had contracted MA-fluA in the prior season.
[h=4]CONCLUSIONS:[/h] Negative effects of repeated vaccination were significant among those without history of MA-fluA in the prior season.
Copyright ? 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; Past influenza exposure; Repeated vaccination; Vaccine effectiveness
PMID: 28043738 DOI: 10.1016/j.vaccine.2016.11.024
[PubMed - as supplied by publisher]