tetano
Editor, Senior Moderator
Diagn Microbiol Infect Dis. 2013 Jun 3. pii: S0732-8893(13)00268-X. doi: 10.1016/j.diagmicrobio.2013.04.029. [Epub ahead of print]
Near point-of-care administration by the attending physician of the rapid influenza antigen detection immunochromatography test and the fully automated respiratory virus nucleic acid test: contribution to patient management.
Boku S, Naito T, Murai K, Tanei M, Inui A, Nisimura H, Isonuma H, Takahashi H, Kikuchi K.
Source
Department of General Medicine, Juntendo University Nerima Hospital, Tokyo, Japan; Department of General Medicine, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: sboku@juntendo.ac.jp.
Abstract
Rapid influenza antigen detection tests (RIADTs) using immunochromatography are the most readily available tools for the diagnosis and management of influenza. This study was designed to assess whether near point-of-care administration by primary care physicians of the RIADT and a fully automated respiratory virus nucleic acid test (Verigene Respiratory Virus Plus?; RV+) would contribute to improved patient management. When viral culture and RT-PCR/bi-directional sequencing were used as the gold standard, sensitivities and specificities for RIADT and RV+ were 58.3% and 90.9%, and 97.2% and 100%, respectively. Within 12 hours from onset of fever, sensitivities were 44.4% and 94.4%, respectively, for RIADT and RV+. In clinical situations where a higher-sensitivity test is needed, such as during pre-admission evaluations, for testing of hospital employees during the prodromal phase of infection, during the therapeutic decision-making process, and during outbreaks, we suggest that patients testing negative by the RIADT can be reassessed with the RV+ test to achieve maximal diagnostic accuracy.
Copyright ? 2013 Elsevier Inc. All rights reserved.
PMID:
23743175
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23743175
Near point-of-care administration by the attending physician of the rapid influenza antigen detection immunochromatography test and the fully automated respiratory virus nucleic acid test: contribution to patient management.
Boku S, Naito T, Murai K, Tanei M, Inui A, Nisimura H, Isonuma H, Takahashi H, Kikuchi K.
Source
Department of General Medicine, Juntendo University Nerima Hospital, Tokyo, Japan; Department of General Medicine, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: sboku@juntendo.ac.jp.
Abstract
Rapid influenza antigen detection tests (RIADTs) using immunochromatography are the most readily available tools for the diagnosis and management of influenza. This study was designed to assess whether near point-of-care administration by primary care physicians of the RIADT and a fully automated respiratory virus nucleic acid test (Verigene Respiratory Virus Plus?; RV+) would contribute to improved patient management. When viral culture and RT-PCR/bi-directional sequencing were used as the gold standard, sensitivities and specificities for RIADT and RV+ were 58.3% and 90.9%, and 97.2% and 100%, respectively. Within 12 hours from onset of fever, sensitivities were 44.4% and 94.4%, respectively, for RIADT and RV+. In clinical situations where a higher-sensitivity test is needed, such as during pre-admission evaluations, for testing of hospital employees during the prodromal phase of infection, during the therapeutic decision-making process, and during outbreaks, we suggest that patients testing negative by the RIADT can be reassessed with the RV+ test to achieve maximal diagnostic accuracy.
Copyright ? 2013 Elsevier Inc. All rights reserved.
PMID:
23743175
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23743175