tetano
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Nature | Article Accelerated Article Preview
[h=1]Structural basis of potent Zika?dengue virus antibody cross-neutralization[/h]
Zika virus is a member of the flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barr? syndrome in adults in French Polynesia. Zika virus is related to dengue virus, and we report here that a category of antibodies isolated from dengue patients and targeting a conformational epitope potently neutralize Zika virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor prM protein during virus maturation. Comparison of the Zika and dengue virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect against Zika and dengue viruses simultaneously.
http://www.nature.com/nature/journal/vaap/ncurrent/full/nature18938.html
[h=1]Structural basis of potent Zika?dengue virus antibody cross-neutralization[/h]
- Giovanna Barba-Spaeth[SUP]1, 2[/SUP][SUP], n1[/SUP]
- Wanwisa Dejnirattisai[SUP]3[/SUP][SUP], n1[/SUP]
- Alexander Rouvinski[SUP]1, 2[/SUP][SUP], n1[/SUP]
- Marie-Christine Vaney[SUP]1, 2[/SUP][SUP], n1[/SUP]
- Iris Medits[SUP]4[/SUP][SUP], [/SUP]
- Arvind Sharma[SUP]1, 2[/SUP][SUP], [/SUP]
- Etienne Simon-Lori?re[SUP]5, 6[/SUP][SUP], [/SUP]
- Anavaj Sakuntabhai[SUP]5, 6[/SUP][SUP], [/SUP]
- Van-Mai Cao-Lormeau[SUP]7[/SUP][SUP], [/SUP]
- Ahmed Haouz[SUP]8[/SUP][SUP], [/SUP]
- Patrick England[SUP]9[/SUP][SUP], [/SUP]
- Karin Stiasny[SUP]4[/SUP][SUP], [/SUP]
- Juthathip Mongkolsapaya[SUP]3, 10[/SUP][SUP], [/SUP]
- Franz X. Heinz[SUP]4[/SUP][SUP], [/SUP]
- Gavin R. Screaton[SUP]3[/SUP][SUP], [/SUP]
- F?lix A. Rey[SUP]1, 2[/SUP][SUP], [/SUP]
Zika virus is a member of the flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barr? syndrome in adults in French Polynesia. Zika virus is related to dengue virus, and we report here that a category of antibodies isolated from dengue patients and targeting a conformational epitope potently neutralize Zika virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor prM protein during virus maturation. Comparison of the Zika and dengue virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect against Zika and dengue viruses simultaneously.
http://www.nature.com/nature/journal/vaap/ncurrent/full/nature18938.html
