Nature: SARS and MERS: recent insights into emerging coronaviruses

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Nature Reviews Microbiology | Review

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[h=1]SARS and MERS: recent insights into emerging coronaviruses[/h]

• Emmie de Wit,
• Neeltje van Doremalen,
• Darryl Falzarano
• & Vincent J. Munster

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Nature Reviews Microbiology (2016) doi:10.1038/nrmicro.2016.81 Published online 27 June 2016
[h=1]Abstract[/h]

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The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. The continuing introductions of MERS-CoV from dromedary camels, the subsequent travel-related viral spread, the unprecedented nosocomial outbreaks and the high case-fatality rates highlight the need for prophylactic and therapeutic measures. Scientific advancements since the 2002?2003 severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic allowed for rapid progress in our understanding of the epidemiology and pathogenesis of MERS-CoV and the development of therapeutics. In this Review, we detail our present understanding of the transmission and pathogenesis of SARS-CoV and MERS-CoV, and discuss the current state of development of measures to combat emerging coronaviruses.

http://www.nature.com/nrmicro/journal/vaop/ncurrent/full/nrmicro.2016.81.html