Mary Wilson
Well-known member
Received: 18 October 2020
Accepted: 9 February 2021P
Published on line: 22 March 2021
Ani Nalbandian 1,24, Kartik Sehgal 2,3,4,24?, Aakriti Gupta 1,5,6, Mahesh V. Madhavan 1,5, Claire McGroder 7, Jacob S. Stevens8, Joshua R. Cook 9, Anna S. Nordvig 10, Daniel Shalev11, Tejasav S. Sehrawat 12, Neha Ahluwalia13, Behnood Bikdeli4,5,6,14, Donald Dietz15,
Caroline Der-Nigoghossian16, Nadia Liyanage-Don17, Gregg F. Rosner1, Elana J. Bernstein 18, Sumit Mohan 8, Akinpelumi A. Beckley19, David S. Seres20, Toni K. Choueiri 2,3,4, Nir Uriel1, John C. Ausiello9, Domenico Accili9, Daniel E. Freedberg21, Matthew Baldwin 7, Allan Schwartz1, Daniel Brodie 7, Christine Kim Garcia7, Mitchell S. V. Elkind 10,22, Jean M. Connors4,23,
John P. Bilezikian9, Donald W. Landry8 and Elaine Y. Wan 1?
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics.
https://www.nature.com/articles/s41591-021-01283-z.pdf
Accepted: 9 February 2021P
Published on line: 22 March 2021
Ani Nalbandian 1,24, Kartik Sehgal 2,3,4,24?, Aakriti Gupta 1,5,6, Mahesh V. Madhavan 1,5, Claire McGroder 7, Jacob S. Stevens8, Joshua R. Cook 9, Anna S. Nordvig 10, Daniel Shalev11, Tejasav S. Sehrawat 12, Neha Ahluwalia13, Behnood Bikdeli4,5,6,14, Donald Dietz15,
Caroline Der-Nigoghossian16, Nadia Liyanage-Don17, Gregg F. Rosner1, Elana J. Bernstein 18, Sumit Mohan 8, Akinpelumi A. Beckley19, David S. Seres20, Toni K. Choueiri 2,3,4, Nir Uriel1, John C. Ausiello9, Domenico Accili9, Daniel E. Freedberg21, Matthew Baldwin 7, Allan Schwartz1, Daniel Brodie 7, Christine Kim Garcia7, Mitchell S. V. Elkind 10,22, Jean M. Connors4,23,
John P. Bilezikian9, Donald W. Landry8 and Elaine Y. Wan 1?
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics.
https://www.nature.com/articles/s41591-021-01283-z.pdf