Giuseppe
Emeritus
[Source: Nature, full text: (LINK). Summary, edited.]
------
Immunology: Crystal ball for flu vaccines
Journal name: Nature
Volume: 475, Page: 142
Date published: (14 July 2011)
DOI: doi:10.1038/475142b
Published online 13 July 2011
People's immune response to an influenza vaccine can be predicted after vaccination from gene-expression signatures.
Bali Pulendran at Emory University in Atlanta, Georgia, and his colleagues measured immune responses and gene-expression changes in the white blood cells of 56 volunteers who received the inactivated vaccine against seasonal flu. Expression levels of 42 sets of 3 or 4 genes were used to predict flu-specific antibody response to the inactivated vaccine. For example, levels of the gene CaMKIV were inversely correlated with the antibody responses.
</DT>Subject terms:
-Journal name: Nature
Volume: 475, Page: 142
Date published: (14 July 2011)
DOI: doi:10.1038/475142b
Published online 13 July 2011
People's immune response to an influenza vaccine can be predicted after vaccination from gene-expression signatures.
Bali Pulendran at Emory University in Atlanta, Georgia, and his colleagues measured immune responses and gene-expression changes in the white blood cells of 56 volunteers who received the inactivated vaccine against seasonal flu. Expression levels of 42 sets of 3 or 4 genes were used to predict flu-specific antibody response to the inactivated vaccine. For example, levels of the gene CaMKIV were inversely correlated with the antibody responses.
</DT>Subject terms:
------