tetano
Editor, Senior Moderator
Nature
. 2021 Oct 21.
doi: 10.1038/s41586-021-04120-y. Online ahead of print.
Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination
Bruno Pozzetto[SUP] #[/SUP][SUP] 1 [/SUP], Vincent Legros[SUP] #[/SUP][SUP] 1 2 [/SUP], Sophia Djebali[SUP] #[/SUP][SUP] 1 [/SUP], Véronique Barateau[SUP] #[/SUP][SUP] 1 [/SUP], Nicolas Guibert[SUP] 3 [/SUP], Marine Villard[SUP] 1 [/SUP], Loïc Peyrot[SUP] 1 [/SUP], Omran Allatif[SUP] 1 [/SUP], Jean-Baptiste Fassier[SUP] 3 [/SUP], Amélie Massardier-Pilonchéry[SUP] 3 [/SUP], Karen Brengel-Pesce[SUP] 4 [/SUP], Melyssa Yaugel-Novoa[SUP] 1 [/SUP], Solène Denolly[SUP] 1 [/SUP], Bertrand Boson[SUP] 1 [/SUP], Thomas Bourlet[SUP] 1 [/SUP], Antonin Bal[SUP] 1 5 [/SUP], Martine Valette[SUP] 5 [/SUP], Thibault Andrieu[SUP] 6 [/SUP], Bruno Lina[SUP] 1 5 [/SUP], Covid-Ser study group; François-Loïc Cosset[SUP] 7 [/SUP], Stéphane Paul[SUP] 8 [/SUP], Thierry Defrance[SUP] 9 [/SUP], Jacqueline Marvel[SUP] 10 [/SUP], Thierry Walzer[SUP] 11 [/SUP], Sophie Trouillet-Assant[SUP] 12 13 [/SUP]
Collaborators, Affiliations
Abstract
Following severe adverse reactions to the AstraZeneca ChAdOx1-S-nCoV-19 vaccine[SUP]1,2[/SUP], European health authorities have recommended that patients under the age of 55 who received one dose of ChAdOx1-S-nCoV-19 vaccine receive a second dose of Pfizer BNT162b2 vaccine as a booster. However, the effectiveness and the immunogenicity of this vaccination regimen have not been formally tested. Here, we show that the heterologous ChAdOx1-S-nCoV-19/BNT162b2 combination confers better protection against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection than the homologous BNT162b2/BNT162b2 combination in a real-world observational study of healthcare workers (n=13121). To understand the underlying mechanism, we conducted a longitudinal survey of the anti-spike immunity conferred by each vaccine combination. Both combinations induced strong anti-spike antibody (Ab) responses but sera from heterologous vaccinated individuals displayed a stronger neutralizing activity, regardless of the SARS-CoV-2 variant. This enhanced neutralizing potential was correlated with increased frequencies of switched and activated memory B cells recognizing the SARS-CoV-2 Receptor Binding Domain (RBD). The ChAdOx1-S-nCoV-19 vaccine induced a weaker IgG response but a stronger T cell response than the BNT162b2 vaccine after the priming dose, which could explain the complementarity of both vaccines when used in combination. The heterologous vaccination regimen could therefore be particularly suitable for immune compromised individuals.
. 2021 Oct 21.
doi: 10.1038/s41586-021-04120-y. Online ahead of print.
Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination
Bruno Pozzetto[SUP] #[/SUP][SUP] 1 [/SUP], Vincent Legros[SUP] #[/SUP][SUP] 1 2 [/SUP], Sophia Djebali[SUP] #[/SUP][SUP] 1 [/SUP], Véronique Barateau[SUP] #[/SUP][SUP] 1 [/SUP], Nicolas Guibert[SUP] 3 [/SUP], Marine Villard[SUP] 1 [/SUP], Loïc Peyrot[SUP] 1 [/SUP], Omran Allatif[SUP] 1 [/SUP], Jean-Baptiste Fassier[SUP] 3 [/SUP], Amélie Massardier-Pilonchéry[SUP] 3 [/SUP], Karen Brengel-Pesce[SUP] 4 [/SUP], Melyssa Yaugel-Novoa[SUP] 1 [/SUP], Solène Denolly[SUP] 1 [/SUP], Bertrand Boson[SUP] 1 [/SUP], Thomas Bourlet[SUP] 1 [/SUP], Antonin Bal[SUP] 1 5 [/SUP], Martine Valette[SUP] 5 [/SUP], Thibault Andrieu[SUP] 6 [/SUP], Bruno Lina[SUP] 1 5 [/SUP], Covid-Ser study group; François-Loïc Cosset[SUP] 7 [/SUP], Stéphane Paul[SUP] 8 [/SUP], Thierry Defrance[SUP] 9 [/SUP], Jacqueline Marvel[SUP] 10 [/SUP], Thierry Walzer[SUP] 11 [/SUP], Sophie Trouillet-Assant[SUP] 12 13 [/SUP]
Collaborators, Affiliations
- PMID: 34673755
- DOI: 10.1038/s41586-021-04120-y
Abstract
Following severe adverse reactions to the AstraZeneca ChAdOx1-S-nCoV-19 vaccine[SUP]1,2[/SUP], European health authorities have recommended that patients under the age of 55 who received one dose of ChAdOx1-S-nCoV-19 vaccine receive a second dose of Pfizer BNT162b2 vaccine as a booster. However, the effectiveness and the immunogenicity of this vaccination regimen have not been formally tested. Here, we show that the heterologous ChAdOx1-S-nCoV-19/BNT162b2 combination confers better protection against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection than the homologous BNT162b2/BNT162b2 combination in a real-world observational study of healthcare workers (n=13121). To understand the underlying mechanism, we conducted a longitudinal survey of the anti-spike immunity conferred by each vaccine combination. Both combinations induced strong anti-spike antibody (Ab) responses but sera from heterologous vaccinated individuals displayed a stronger neutralizing activity, regardless of the SARS-CoV-2 variant. This enhanced neutralizing potential was correlated with increased frequencies of switched and activated memory B cells recognizing the SARS-CoV-2 Receptor Binding Domain (RBD). The ChAdOx1-S-nCoV-19 vaccine induced a weaker IgG response but a stronger T cell response than the BNT162b2 vaccine after the priming dose, which could explain the complementarity of both vaccines when used in combination. The heterologous vaccination regimen could therefore be particularly suitable for immune compromised individuals.