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Nature Communications: Presence of SARS-CoV-2 in fetal organs via intraamniotic infection - November 21, 2025

sharon sanders

Editor-in-Chief & President
Presence of SARS-CoV-2 in fetal organs via intraamniotic infection
Nature Communications

volume 16, Article number: 10261 (2025) Cite this article


Abstract


The COVID-19 pandemic underlined the need to focus on women’s health, particularly during pregnancy. Recent studies have shown that maternal SARS-CoV-2 infection during pregnancy may increase obstetrical risks. However, intraamniotic SARS-CoV-2 infection has been understudied. Here, we conduct inclusive autopsies on 18 fetuses following maternal SARS-CoV-2 infection to determine whether and which fetal organs can be infected by SARS-CoV-2 in utero. We analyze a total of 538 samples from 32 tissue types to comprehensively map and quantify the distribution and replication patterns of SARS-CoV-2 across fetal organs. Our observations reveal that SARS-CoV-2 can be widely distributed in fetal organs through vertical transmission. As the length of time from SARS-CoV-2 infection to termination of pregnancy increases, the prevalence of infection in fetal organs decrease. Further, proteomic profiling reveals DNA damage and immune imbalance in infected organs.

https://www.nature.com/articles/s41467-025-65131-1
 
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