Nature Communications: Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

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Nature Communications | Article Open



Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

Yong-Hong Zhang,
Yan Zhao,
Ning Li,
Yan-Chun Peng,
Eleni Giannoulatou,
Rong-Hua Jin,
Hui-Ping Yan,
Hao Wu,
Jin-Hua Liu,
Ning Liu,
Da-Yan Wang,
Yue-Long Shu,
Ling-Pei Ho,
Paul Kellam,
Andrew McMichael
& Tao Dong


Nature Communications
4,
Article number:
1418
doi:10.1038/ncomms2433


The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.

full article

http://www.nature.com/ncomms/journal/v4/n1/full/ncomms2433.html

 

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Re: Nature Communications: Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

Source: http://www.ctvnews.ca/health/chines...w-flu-virus-hits-some-groups-harder-1.1134772

Chinese genetics may explain how flu virus hits some groups harder
The Associated Press
Published Tuesday, Jan. 29, 2013 4:31PM EST

LONDON -- A genetic variant commonly found in Chinese people may help explain why some got seriously ill with swine flu, a discovery scientists say could help pinpoint why flu viruses hit some populations particularly hard and change how they are treated.

Less than one percent of Caucasians are thought to have the gene alteration, which has previously been linked to severe influenza. Yet about 25 percent of Chinese people have the gene variant, which is also common in Japanese and Korean people.

British and Chinese researchers analyzed 83 patients admitted to a Beijing hospital during the 2009-2010 swine flu pandemic. Of those with serious complications like pneumonia, respiratory or kidney failure, 69 percent had the genetic alteration. Among patients with mild illness, only 25 percent did...