tetano
Editor, Senior Moderator
Nature
. 2020 Sep 23.
doi: 10.1038/s41586-020-2787-6. Online ahead of print.
Animal models for COVID-19
C?sar Mu?oz-Fontela[SUP] 1 [/SUP], William E Dowling[SUP] 2 [/SUP], Simon G P Funnell[SUP] 3 [/SUP], Pierre-S Gsell[SUP] 4 [/SUP], Ximena Riveros Balta[SUP] 4 [/SUP], Randy A Albrecht[SUP] 5 [/SUP], Hanne Andersen[SUP] 6 [/SUP], Ralph S Baric[SUP] 7 [/SUP], Miles W Carroll[SUP] 3 [/SUP], Marco Cavaleri[SUP] 8 [/SUP], Chuan Qin[SUP] 9 [/SUP], Ian Crozier[SUP] 10 [/SUP], Kai Dallmeier[SUP] 11 [/SUP], Leon de Waal[SUP] 12 [/SUP], Emmie de Wit[SUP] 13 [/SUP], Leen Delang[SUP] 11 [/SUP], Erik Dohm[SUP] 14 [/SUP], W Paul Duprex[SUP] 15 [/SUP], Darryl Falzarano[SUP] 16 [/SUP], Courtney L Finch[SUP] 17 [/SUP], Matthew B Frieman[SUP] 18 [/SUP], Barney S Graham[SUP] 19 [/SUP], Lisa Gralinski[SUP] 20 [/SUP], Kate Guilfoyle[SUP] 12 [/SUP], Bart L Haagmans[SUP] 21 [/SUP], Geraldine A Hamilton[SUP] 22 [/SUP], Amy L Hartman[SUP] 15 [/SUP], Sander Herfst[SUP] 21 [/SUP], Suzanne J F Kaptein[SUP] 11 [/SUP], William Klimstra[SUP] 23 [/SUP], Ivana Knezevic[SUP] 4 [/SUP], Phillip R Krause[SUP] 24 [/SUP], Jens H Kuhn[SUP] 17 [/SUP], Roger Le Grand[SUP] 25 [/SUP], Mark Lewis[SUP] 6 [/SUP], Wen-Chun Liu[SUP] 5 [/SUP], Pauline Maisonnasse[SUP] 24 [/SUP], Anita K McElroy[SUP] 26 [/SUP], Vincent Munster[SUP] 13 [/SUP], Nadia Oreshkova[SUP] 27 [/SUP], Angela L Rasmussen[SUP] 28 [/SUP], Joana Rocha-Pereira[SUP] 11 [/SUP], Barry Rockx[SUP] 21 [/SUP], Estefan?a Rodr?guez[SUP] 1 [/SUP], Thomas Rogers[SUP] 29 [/SUP], Francisco J Salguero[SUP] 3 [/SUP], Michael Schotsaert[SUP] 5 [/SUP], Koert Stittelaar[SUP] 12 [/SUP], Hendrik Jan Thibaut[SUP] 11 [/SUP], Chien-Te Tseng[SUP] 30 [/SUP], J?lia Vergara-Alert[SUP] 31 [/SUP], Martin Beer[SUP] 32 [/SUP], Trevor Brasel[SUP] 30 [/SUP], Jasper F W Chan[SUP] 33 [/SUP], Adolfo Garc?a-Sastre[SUP] 5 [/SUP], Johan Neyts[SUP] 11 [/SUP], Stanley Perlman[SUP] 34 [/SUP], Douglas S Reed[SUP] 15 [/SUP], Juergen A Richt[SUP] 35 [/SUP], Chad J Roy[SUP] 36 [/SUP], Joaquim Segal?s[SUP] 31 [/SUP], Seshadri S Vasan[SUP] 37 38 [/SUP], Ana Mar?a Henao-Restrepo[SUP] 39 [/SUP], Dan H Barouch[SUP] 40 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by introduction of a novel coronavirus into humans in late 2019 in China's Hubei province. As of September 11, 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 28 million people, and has caused more than 910,000 deaths. Since humans do not have pre-existing immunity against SARS-CoV-2, there is an urgent need to develop therapeutics and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19 in the future. In February 2020 the World Health Organization (WHO) assembled an international panel of experts to develop animal models for COVID-19 to accelerate testing of vaccines and therapeutics. This review summarizes the findings to date and provides relevant information for preclinical testing of COVID-19 vaccine candidates and therapeutics.
. 2020 Sep 23.
doi: 10.1038/s41586-020-2787-6. Online ahead of print.
Animal models for COVID-19
C?sar Mu?oz-Fontela[SUP] 1 [/SUP], William E Dowling[SUP] 2 [/SUP], Simon G P Funnell[SUP] 3 [/SUP], Pierre-S Gsell[SUP] 4 [/SUP], Ximena Riveros Balta[SUP] 4 [/SUP], Randy A Albrecht[SUP] 5 [/SUP], Hanne Andersen[SUP] 6 [/SUP], Ralph S Baric[SUP] 7 [/SUP], Miles W Carroll[SUP] 3 [/SUP], Marco Cavaleri[SUP] 8 [/SUP], Chuan Qin[SUP] 9 [/SUP], Ian Crozier[SUP] 10 [/SUP], Kai Dallmeier[SUP] 11 [/SUP], Leon de Waal[SUP] 12 [/SUP], Emmie de Wit[SUP] 13 [/SUP], Leen Delang[SUP] 11 [/SUP], Erik Dohm[SUP] 14 [/SUP], W Paul Duprex[SUP] 15 [/SUP], Darryl Falzarano[SUP] 16 [/SUP], Courtney L Finch[SUP] 17 [/SUP], Matthew B Frieman[SUP] 18 [/SUP], Barney S Graham[SUP] 19 [/SUP], Lisa Gralinski[SUP] 20 [/SUP], Kate Guilfoyle[SUP] 12 [/SUP], Bart L Haagmans[SUP] 21 [/SUP], Geraldine A Hamilton[SUP] 22 [/SUP], Amy L Hartman[SUP] 15 [/SUP], Sander Herfst[SUP] 21 [/SUP], Suzanne J F Kaptein[SUP] 11 [/SUP], William Klimstra[SUP] 23 [/SUP], Ivana Knezevic[SUP] 4 [/SUP], Phillip R Krause[SUP] 24 [/SUP], Jens H Kuhn[SUP] 17 [/SUP], Roger Le Grand[SUP] 25 [/SUP], Mark Lewis[SUP] 6 [/SUP], Wen-Chun Liu[SUP] 5 [/SUP], Pauline Maisonnasse[SUP] 24 [/SUP], Anita K McElroy[SUP] 26 [/SUP], Vincent Munster[SUP] 13 [/SUP], Nadia Oreshkova[SUP] 27 [/SUP], Angela L Rasmussen[SUP] 28 [/SUP], Joana Rocha-Pereira[SUP] 11 [/SUP], Barry Rockx[SUP] 21 [/SUP], Estefan?a Rodr?guez[SUP] 1 [/SUP], Thomas Rogers[SUP] 29 [/SUP], Francisco J Salguero[SUP] 3 [/SUP], Michael Schotsaert[SUP] 5 [/SUP], Koert Stittelaar[SUP] 12 [/SUP], Hendrik Jan Thibaut[SUP] 11 [/SUP], Chien-Te Tseng[SUP] 30 [/SUP], J?lia Vergara-Alert[SUP] 31 [/SUP], Martin Beer[SUP] 32 [/SUP], Trevor Brasel[SUP] 30 [/SUP], Jasper F W Chan[SUP] 33 [/SUP], Adolfo Garc?a-Sastre[SUP] 5 [/SUP], Johan Neyts[SUP] 11 [/SUP], Stanley Perlman[SUP] 34 [/SUP], Douglas S Reed[SUP] 15 [/SUP], Juergen A Richt[SUP] 35 [/SUP], Chad J Roy[SUP] 36 [/SUP], Joaquim Segal?s[SUP] 31 [/SUP], Seshadri S Vasan[SUP] 37 38 [/SUP], Ana Mar?a Henao-Restrepo[SUP] 39 [/SUP], Dan H Barouch[SUP] 40 [/SUP]
Affiliations
- PMID: 32967005
- DOI: 10.1038/s41586-020-2787-6
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by introduction of a novel coronavirus into humans in late 2019 in China's Hubei province. As of September 11, 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 28 million people, and has caused more than 910,000 deaths. Since humans do not have pre-existing immunity against SARS-CoV-2, there is an urgent need to develop therapeutics and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19 in the future. In February 2020 the World Health Organization (WHO) assembled an international panel of experts to develop animal models for COVID-19 to accelerate testing of vaccines and therapeutics. This review summarizes the findings to date and provides relevant information for preclinical testing of COVID-19 vaccine candidates and therapeutics.