tetano
Editor, Senior Moderator
Nature
. 2025 Oct 15.
doi: 10.1038/s41586-025-09626-3. Online ahead of print. A vaccine central in A(H5) influenza antigenic space confers broad immunity
Adinda Kok[SUP] 1 2 [/SUP], Samuel H Wilks[SUP] #[/SUP][SUP] 3 4 [/SUP], Sina Tureli[SUP] #[/SUP][SUP] 3 [/SUP], Sarah L James[SUP] #[/SUP][SUP] 3 [/SUP], Theo M Bestebroer[SUP] 1 [/SUP], David F Burke[SUP] 3 5 [/SUP], Mathis Funk[SUP] 1 [/SUP], Stefan van der Vliet[SUP] 1 [/SUP], Monique I Spronken[SUP] 1 [/SUP], Willemijn F Rijnink[SUP] 1 [/SUP], David J Pattinson[SUP] 3 6 [/SUP], Dennis de Meulder[SUP] 1 [/SUP], Miruna E Rosu[SUP] 1 [/SUP], Pascal Lexmond[SUP] 1 [/SUP], Judith M A van den Brand[SUP] 7 [/SUP], Sander Herfst[SUP] 1 [/SUP], Derek J Smith[SUP] 3 [/SUP], Ron A M Fouchier[SUP] 1 [/SUP], Mathilde Richard[SUP] 8 [/SUP]
Affiliations
Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, and have caused severe infections in mammals, including humans, underscoring their pandemic potential[SUP]1-5[/SUP]. The antigenic evolution of the A(H5) haemagglutinin (HA) poses challenges for pandemic preparedness and vaccine design[SUP]6[/SUP]. Here the global antigenic evolution of the A(H5) HA was captured in a high-resolution antigenic map. The map was used to design immunogenic and antigenically central vaccine HA antigens, eliciting antibody responses that broadly cover the A(H5) antigenic space. In ferrets, a central antigen protected as well as homologous vaccines against heterologous infection with two antigenically distinct viruses. This work showcases the rational design of subtype-wide influenza A(H5) pre-pandemic vaccines and demonstrates the value of antigenic maps for the evaluation of vaccine-induced immune responses through antibody profiles.
. 2025 Oct 15.
doi: 10.1038/s41586-025-09626-3. Online ahead of print. A vaccine central in A(H5) influenza antigenic space confers broad immunity
Adinda Kok[SUP] 1 2 [/SUP], Samuel H Wilks[SUP] #[/SUP][SUP] 3 4 [/SUP], Sina Tureli[SUP] #[/SUP][SUP] 3 [/SUP], Sarah L James[SUP] #[/SUP][SUP] 3 [/SUP], Theo M Bestebroer[SUP] 1 [/SUP], David F Burke[SUP] 3 5 [/SUP], Mathis Funk[SUP] 1 [/SUP], Stefan van der Vliet[SUP] 1 [/SUP], Monique I Spronken[SUP] 1 [/SUP], Willemijn F Rijnink[SUP] 1 [/SUP], David J Pattinson[SUP] 3 6 [/SUP], Dennis de Meulder[SUP] 1 [/SUP], Miruna E Rosu[SUP] 1 [/SUP], Pascal Lexmond[SUP] 1 [/SUP], Judith M A van den Brand[SUP] 7 [/SUP], Sander Herfst[SUP] 1 [/SUP], Derek J Smith[SUP] 3 [/SUP], Ron A M Fouchier[SUP] 1 [/SUP], Mathilde Richard[SUP] 8 [/SUP]
Affiliations
- PMID: 41094140
- DOI: 10.1038/s41586-025-09626-3
Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, and have caused severe infections in mammals, including humans, underscoring their pandemic potential[SUP]1-5[/SUP]. The antigenic evolution of the A(H5) haemagglutinin (HA) poses challenges for pandemic preparedness and vaccine design[SUP]6[/SUP]. Here the global antigenic evolution of the A(H5) HA was captured in a high-resolution antigenic map. The map was used to design immunogenic and antigenically central vaccine HA antigens, eliciting antibody responses that broadly cover the A(H5) antigenic space. In ferrets, a central antigen protected as well as homologous vaccines against heterologous infection with two antigenically distinct viruses. This work showcases the rational design of subtype-wide influenza A(H5) pre-pandemic vaccines and demonstrates the value of antigenic maps for the evaluation of vaccine-induced immune responses through antibody profiles.