tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2018 Aug 30. doi: 10.1097/INF.0000000000002177. [Epub ahead of print]
[h=1]Nationwide Study on the Course of Influenza A (H1N1) Infections in Hospitalized Children in the Netherlands During the Pandemic 2009-2010.[/h] Ahout IML[SUP]1[/SUP], Philipsen RLA[SUP]1[/SUP], Las M[SUP]1,[/SUP][SUP]2[/SUP], Baysan M[SUP]1[/SUP], Brus F[SUP]3[/SUP], Rahamat-Langendoen JC[SUP]4[/SUP], Roeleveld N[SUP]5[/SUP], Fraaij PL[SUP]6,[/SUP][SUP]7[/SUP], Osterhaus ADME[SUP]8,[/SUP][SUP]9[/SUP], Ferwerda G[SUP]1[/SUP], de Groot R[SUP]1[/SUP]; Dutch H1N1 Research Group..
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The influenza H1N1 pandemic of 2009-2010, provided a unique opportunity to assess the course of disease, as well as the analysis of risk factors for severe disease in hospitalized children (<18 years).
[h=4]METHODS:[/h] Retrospective national chart study on hospitalized children with H1N1 infection during the 2009-2010 pH1N1 outbreak.
[h=4]RESULTS:[/h] 940 patients (56% boys), median age 3.0 year, were enrolled; the majority were previously healthy. Treatment consisted of supplemental oxygen (24%), mechanical ventilation (5%) and antiviral therapy (63%). Fifteen patients died (1.6%), 5 of whom were previously healthy. Multivariable analyses confirmed pre-existent heart and lung disease as risk factors for ICU admission. Risk factors for mortality included children with a neurologic or oncologic disease and psychomotor retardation.
[h=4]CONCLUSIONS:[/h] This nationwide overview of hospitalized children confirms known risk groups for severe influenza infections. However, most of the acute and severe presentations of influenza occurred in previously healthy children.
PMID: 30169483 DOI: 10.1097/INF.0000000000002177
[h=1]Nationwide Study on the Course of Influenza A (H1N1) Infections in Hospitalized Children in the Netherlands During the Pandemic 2009-2010.[/h] Ahout IML[SUP]1[/SUP], Philipsen RLA[SUP]1[/SUP], Las M[SUP]1,[/SUP][SUP]2[/SUP], Baysan M[SUP]1[/SUP], Brus F[SUP]3[/SUP], Rahamat-Langendoen JC[SUP]4[/SUP], Roeleveld N[SUP]5[/SUP], Fraaij PL[SUP]6,[/SUP][SUP]7[/SUP], Osterhaus ADME[SUP]8,[/SUP][SUP]9[/SUP], Ferwerda G[SUP]1[/SUP], de Groot R[SUP]1[/SUP]; Dutch H1N1 Research Group..
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The influenza H1N1 pandemic of 2009-2010, provided a unique opportunity to assess the course of disease, as well as the analysis of risk factors for severe disease in hospitalized children (<18 years).
[h=4]METHODS:[/h] Retrospective national chart study on hospitalized children with H1N1 infection during the 2009-2010 pH1N1 outbreak.
[h=4]RESULTS:[/h] 940 patients (56% boys), median age 3.0 year, were enrolled; the majority were previously healthy. Treatment consisted of supplemental oxygen (24%), mechanical ventilation (5%) and antiviral therapy (63%). Fifteen patients died (1.6%), 5 of whom were previously healthy. Multivariable analyses confirmed pre-existent heart and lung disease as risk factors for ICU admission. Risk factors for mortality included children with a neurologic or oncologic disease and psychomotor retardation.
[h=4]CONCLUSIONS:[/h] This nationwide overview of hospitalized children confirms known risk groups for severe influenza infections. However, most of the acute and severe presentations of influenza occurred in previously healthy children.
PMID: 30169483 DOI: 10.1097/INF.0000000000002177