Ronan Kelly
Retired 2020
Lancet Glob Health. 2019 Dec;7(12):e1675-e1684. doi: 10.1016/S2214-109X(19)30451-6.
National Burden Estimates of healthy life lost in India, 2017: an analysis using direct mortality data and indirect disability data.
Menon GR1, Singh L2, Sharma P2, Yadav P2, Sharma S2, Kalaskar S2, Singh H2, Adinarayanan S2, Joshua V2, Kulothungan V2, Yadav J2, Watson LK3, Fadel SA3, Suraweera W3, Rao MVV2, Dhaliwal RS2, Begum R3, Sati P3, Jamison DT4, Jha P5.
Author information
1Indian Council of Medical Research, Ansari Nagar, New Delhi, India. Electronic address: menongr.hq@icmr.gov.in.
2Indian Council of Medical Research, Ansari Nagar, New Delhi, India.
3Centre for Global Health Research, St Michael's Hospital, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
4Institute for Global Health Sciences, University of California San Francisco, San Francisco, CA, USA.5
Centre for Global Health Research, St Michael's Hospital, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. Electronic address: prabhat.jha@utoronto.ca.
Abstract
BACKGROUND:
Many countries, including India, seek locally constructed disease burden estimates comprising mortality and loss of health to aid priority setting for the prevention and treatment of diseases. We created the National Burden Estimates (NBE) to provide transparent and understandable disease burdens at the national and subnational levels, and to identify gaps in knowledge.
METHODS:
To calculate the NBE for India, we combined 2017 UN death totals with national and subnational mortality rates for 2010-17 and causes of death from 211 166 verbal autopsy interviews in the Indian Million Death Study for 2010-14. We calculated years of life lost (YLLs) and years lived with disability (YLDs) for 2017 using published YLD-YLL ratios from WHO Global Health Estimates. We grouped causes of death into 45 groups, including ill-defined deaths, and summed YLLs and YLDs to calculate disability-adjusted life-years (DALYs) for these causes in eight age groups covering rural and urban areas and 21 major states of India.
FINDINGS:
In 2017, there were about 9?7 million deaths and 486 million DALYs in India. About three quarters of deaths and DALYs occurred in rural areas. More than a third of national DALYs arose from communicable, maternal, perinatal, and nutritional disorders. DALY rates in rural areas were at least twice those of urban areas for perinatal and nutritional conditions, chronic respiratory diseases, diarrhoea, and fever of unknown origin. DALY rates for ischaemic heart disease were greater in urban areas. Injuries caused 11?4% of DALYs nationally. The top 15 conditions that accounted for the most DALYs were mostly those causing mortality (ischaemic heart disease, perinatal conditions, chronic respiratory diseases, diarrhoea, respiratory infections, cancer, stroke, road traffic accidents, tuberculosis, and liver and alcohol-related conditions), with disability mostly due to a few conditions (nutritional deficiencies, neuropsychiatric conditions, vision and other sensory loss, musculoskeletal disorders, and genitourinary diseases). Every condition that was common in one part of India was uncommon elsewhere, suggesting state-specific priorities for disease control.
INTERPRETATION:
The NBE method quantifies disease burden using transparent, intuitive, and reproducible methods. It provides a simple, locally operable tool to aid policy makers in priority setting in India and other low-income and middle-income countries. The NBE underlines the need for many more countries to collect nationally representative cause of death data, paired with focused surveys of disability.
FUNDING:
Ministry of Health and Family Welfare, Government of India.
Copyright ? 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.
PMID: 31708148 DOI: 10.1016/S2214-109X(19)30451-6
https://www.ncbi.nlm.nih.gov/pubmed/31708148
National Burden Estimates of healthy life lost in India, 2017: an analysis using direct mortality data and indirect disability data.
Menon GR1, Singh L2, Sharma P2, Yadav P2, Sharma S2, Kalaskar S2, Singh H2, Adinarayanan S2, Joshua V2, Kulothungan V2, Yadav J2, Watson LK3, Fadel SA3, Suraweera W3, Rao MVV2, Dhaliwal RS2, Begum R3, Sati P3, Jamison DT4, Jha P5.
Author information
1Indian Council of Medical Research, Ansari Nagar, New Delhi, India. Electronic address: menongr.hq@icmr.gov.in.
2Indian Council of Medical Research, Ansari Nagar, New Delhi, India.
3Centre for Global Health Research, St Michael's Hospital, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
4Institute for Global Health Sciences, University of California San Francisco, San Francisco, CA, USA.5
Centre for Global Health Research, St Michael's Hospital, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. Electronic address: prabhat.jha@utoronto.ca.
Abstract
BACKGROUND:
Many countries, including India, seek locally constructed disease burden estimates comprising mortality and loss of health to aid priority setting for the prevention and treatment of diseases. We created the National Burden Estimates (NBE) to provide transparent and understandable disease burdens at the national and subnational levels, and to identify gaps in knowledge.
METHODS:
To calculate the NBE for India, we combined 2017 UN death totals with national and subnational mortality rates for 2010-17 and causes of death from 211 166 verbal autopsy interviews in the Indian Million Death Study for 2010-14. We calculated years of life lost (YLLs) and years lived with disability (YLDs) for 2017 using published YLD-YLL ratios from WHO Global Health Estimates. We grouped causes of death into 45 groups, including ill-defined deaths, and summed YLLs and YLDs to calculate disability-adjusted life-years (DALYs) for these causes in eight age groups covering rural and urban areas and 21 major states of India.
FINDINGS:
In 2017, there were about 9?7 million deaths and 486 million DALYs in India. About three quarters of deaths and DALYs occurred in rural areas. More than a third of national DALYs arose from communicable, maternal, perinatal, and nutritional disorders. DALY rates in rural areas were at least twice those of urban areas for perinatal and nutritional conditions, chronic respiratory diseases, diarrhoea, and fever of unknown origin. DALY rates for ischaemic heart disease were greater in urban areas. Injuries caused 11?4% of DALYs nationally. The top 15 conditions that accounted for the most DALYs were mostly those causing mortality (ischaemic heart disease, perinatal conditions, chronic respiratory diseases, diarrhoea, respiratory infections, cancer, stroke, road traffic accidents, tuberculosis, and liver and alcohol-related conditions), with disability mostly due to a few conditions (nutritional deficiencies, neuropsychiatric conditions, vision and other sensory loss, musculoskeletal disorders, and genitourinary diseases). Every condition that was common in one part of India was uncommon elsewhere, suggesting state-specific priorities for disease control.
INTERPRETATION:
The NBE method quantifies disease burden using transparent, intuitive, and reproducible methods. It provides a simple, locally operable tool to aid policy makers in priority setting in India and other low-income and middle-income countries. The NBE underlines the need for many more countries to collect nationally representative cause of death data, paired with focused surveys of disability.
FUNDING:
Ministry of Health and Family Welfare, Government of India.
Copyright ? 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.
PMID: 31708148 DOI: 10.1016/S2214-109X(19)30451-6
https://www.ncbi.nlm.nih.gov/pubmed/31708148