tetano
Editor, Senior Moderator
Nat Rev Microbiol
. 2024 Jan 15.
doi: 10.1038/s41579-023-01003-z. Online ahead of print. SARS-CoV-2 biology and host interactions
Silvio Steiner[SUP] 1 2 [/SUP], Annika Kratzel[SUP] 1 2 [/SUP], G Tuba Barut[SUP] 1 2 [/SUP], Reto M Lang[SUP] 1 2 3 [/SUP], Etori Aguiar Moreira[SUP] 1 2 [/SUP], Lisa Thomann[SUP] 1 2 [/SUP], Jenna N Kelly[SUP] 1 2 4 5 [/SUP], Volker Thiel[SUP] 6 7 8 9 [/SUP]
Affiliations
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected our society. The rapid spread and continuous evolution of new SARS-CoV-2 variants continue to threaten global public health. Recent scientific advances have dissected many of the molecular and cellular mechanisms involved in coronavirus infections, and large-scale screens have uncovered novel host-cell factors that are vitally important for the virus life cycle. In this Review, we provide an updated summary of the SARS-CoV-2 life cycle, gene function and virus-host interactions, including recent landmark findings on general aspects of coronavirus biology and newly discovered host factors necessary for virus replication.
. 2024 Jan 15.
doi: 10.1038/s41579-023-01003-z. Online ahead of print. SARS-CoV-2 biology and host interactions
Silvio Steiner[SUP] 1 2 [/SUP], Annika Kratzel[SUP] 1 2 [/SUP], G Tuba Barut[SUP] 1 2 [/SUP], Reto M Lang[SUP] 1 2 3 [/SUP], Etori Aguiar Moreira[SUP] 1 2 [/SUP], Lisa Thomann[SUP] 1 2 [/SUP], Jenna N Kelly[SUP] 1 2 4 5 [/SUP], Volker Thiel[SUP] 6 7 8 9 [/SUP]
Affiliations
- PMID: 38225365
- DOI: 10.1038/s41579-023-01003-z
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected our society. The rapid spread and continuous evolution of new SARS-CoV-2 variants continue to threaten global public health. Recent scientific advances have dissected many of the molecular and cellular mechanisms involved in coronavirus infections, and large-scale screens have uncovered novel host-cell factors that are vitally important for the virus life cycle. In this Review, we provide an updated summary of the SARS-CoV-2 life cycle, gene function and virus-host interactions, including recent landmark findings on general aspects of coronavirus biology and newly discovered host factors necessary for virus replication.