tetano
Editor, Senior Moderator
Nat Med. 2020 May 12. doi: 10.1038/s41591-020-0901-9. [Epub ahead of print]
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Liao M[SUP]1[/SUP], Liu Y[SUP]1[/SUP], Yuan J[SUP]2[/SUP], Wen Y[SUP]1[/SUP], Xu G[SUP]1[/SUP], Zhao J[SUP]1[/SUP], Cheng L[SUP]1[/SUP], Li J[SUP]2[/SUP], Wang X[SUP]1[/SUP], Wang F[SUP]2[/SUP], Liu L[SUP]3,[/SUP][SUP]4[/SUP], Amit I[SUP]5[/SUP], Zhang S[SUP]6[/SUP], Zhang Z[SUP]7,[/SUP][SUP]8[/SUP].
Author information
Abstract
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8[SUP]+[/SUP] T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
PMID:32398875DOI:10.1038/s41591-020-0901-9
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Liao M[SUP]1[/SUP], Liu Y[SUP]1[/SUP], Yuan J[SUP]2[/SUP], Wen Y[SUP]1[/SUP], Xu G[SUP]1[/SUP], Zhao J[SUP]1[/SUP], Cheng L[SUP]1[/SUP], Li J[SUP]2[/SUP], Wang X[SUP]1[/SUP], Wang F[SUP]2[/SUP], Liu L[SUP]3,[/SUP][SUP]4[/SUP], Amit I[SUP]5[/SUP], Zhang S[SUP]6[/SUP], Zhang Z[SUP]7,[/SUP][SUP]8[/SUP].
Author information
Abstract
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8[SUP]+[/SUP] T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
PMID:32398875DOI:10.1038/s41591-020-0901-9