tetano
Editor, Senior Moderator
Nat Med
. 2021 Mar 29.
doi: 10.1038/s41591-021-01316-7. Online ahead of print.
Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine
Matan Levine-Tiefenbrun[SUP] #[/SUP][SUP] 1 [/SUP], Idan Yelin[SUP] #[/SUP][SUP] 2 [/SUP], Rachel Katz[SUP] 3 [/SUP], Esma Herzel[SUP] 3 [/SUP], Ziv Golan[SUP] 4 [/SUP], Licita Schreiber[SUP] 4 [/SUP], Tamar Wolf[SUP] 4 [/SUP], Varda Nadler[SUP] 4 [/SUP], Amir Ben-Tov[SUP] 3 5 [/SUP], Jacob Kuint[SUP] 3 5 [/SUP], Sivan Gazit[SUP] 3 [/SUP], Tal Patalon[SUP] 3 [/SUP], Gabriel Chodick[SUP] 3 5 [/SUP], Roy Kishony[SUP] 6 7 [/SUP]
Affiliations
Abstract
Beyond their substantial protection of individual vaccinees, coronavirus disease 2019 (COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further suppress onward transmission. In this analysis of a real-world dataset of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test results after inoculation with the BNT162b2 messenger RNA vaccine, we found that the viral load was substantially reduced for infections occurring 12-37 d after the first dose of vaccine. These reduced viral loads hint at a potentially lower infectiousness, further contributing to vaccine effect on virus spread.
. 2021 Mar 29.
doi: 10.1038/s41591-021-01316-7. Online ahead of print.
Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine
Matan Levine-Tiefenbrun[SUP] #[/SUP][SUP] 1 [/SUP], Idan Yelin[SUP] #[/SUP][SUP] 2 [/SUP], Rachel Katz[SUP] 3 [/SUP], Esma Herzel[SUP] 3 [/SUP], Ziv Golan[SUP] 4 [/SUP], Licita Schreiber[SUP] 4 [/SUP], Tamar Wolf[SUP] 4 [/SUP], Varda Nadler[SUP] 4 [/SUP], Amir Ben-Tov[SUP] 3 5 [/SUP], Jacob Kuint[SUP] 3 5 [/SUP], Sivan Gazit[SUP] 3 [/SUP], Tal Patalon[SUP] 3 [/SUP], Gabriel Chodick[SUP] 3 5 [/SUP], Roy Kishony[SUP] 6 7 [/SUP]
Affiliations
- PMID: 33782619
- DOI: 10.1038/s41591-021-01316-7
Abstract
Beyond their substantial protection of individual vaccinees, coronavirus disease 2019 (COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further suppress onward transmission. In this analysis of a real-world dataset of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test results after inoculation with the BNT162b2 messenger RNA vaccine, we found that the viral load was substantially reduced for infections occurring 12-37 d after the first dose of vaccine. These reduced viral loads hint at a potentially lower infectiousness, further contributing to vaccine effect on virus spread.