tetano
Editor, Senior Moderator
Nat Commun
. 2021 Jul 6;12(1):4144.
doi: 10.1038/s41467-021-24230-5.
Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
Cesheng Li[SUP] #[/SUP][SUP] 1 [/SUP], Ding Yu[SUP] #[/SUP][SUP] 2 3 [/SUP], Xiao Wu[SUP] 1 [/SUP], Hong Liang[SUP] 2 3 [/SUP], Zhijun Zhou[SUP] 1 [/SUP], Yong Xie[SUP] 1 3 [/SUP], Taojing Li[SUP] 3 [/SUP], Junzheng Wu[SUP] 2 [/SUP], Fengping Lu[SUP] 1 [/SUP], Lu Feng[SUP] 1 [/SUP], Min Mao[SUP] 1 [/SUP], Lianzhen Lin[SUP] 1 [/SUP], Huanhuan Guo[SUP] 1 [/SUP], Shenglan Yue[SUP] 1 [/SUP], Feifei Wang[SUP] 1 [/SUP], Yan Peng[SUP] 1 [/SUP], Yong Hu[SUP] 1 [/SUP], Zejun Wang[SUP] 4 [/SUP], Jianhong Yu[SUP] 1 [/SUP], Yong Zhang[SUP] 3 [/SUP], Jia Lu[SUP] 4 [/SUP], Haoran Ning[SUP] 1 [/SUP], Huichuan Yang[SUP] 5 [/SUP], Daoxing Fu[SUP] 3 [/SUP], Yanlin He[SUP] 1 3 [/SUP], Dongbo Zhou[SUP] 3 [/SUP], Tao Du[SUP] 3 [/SUP], Kai Duan[SUP] 4 [/SUP], Demei Dong[SUP] 3 [/SUP], Kun Deng[SUP] 1 [/SUP], Xia Zou[SUP] 1 [/SUP], Ya Zhang[SUP] 1 [/SUP], Rong Zhou[SUP] 3 [/SUP], Yang Gao[SUP] 3 [/SUP], Xinxin Zhang[SUP] 6 [/SUP], Xiaoming Yang[SUP] 7 [/SUP]
Affiliations
Abstract
To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and test specific antibody responses. The results show that positive rate of IgG antibody against receptor-binding domain of spike protein (RBD-IgG) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the COVID-19 convalescent plasma donors exceeded 70% for 12 months post diagnosis. The level of RBD-IgG decreases with time, with the titer stabilizing at 64.3% of the initial level by the 9th month. Moreover, male plasma donors produce more RBD-IgG than female, and age of the patients positively correlates with the RBD-IgG titer. A strong positive correlation between RBD-IgG and neutralizing antibody titers is also identified. These results facilitate our understanding of SARS-CoV-2-induced immune memory to promote vaccine and therapy development.
. 2021 Jul 6;12(1):4144.
doi: 10.1038/s41467-021-24230-5.
Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
Cesheng Li[SUP] #[/SUP][SUP] 1 [/SUP], Ding Yu[SUP] #[/SUP][SUP] 2 3 [/SUP], Xiao Wu[SUP] 1 [/SUP], Hong Liang[SUP] 2 3 [/SUP], Zhijun Zhou[SUP] 1 [/SUP], Yong Xie[SUP] 1 3 [/SUP], Taojing Li[SUP] 3 [/SUP], Junzheng Wu[SUP] 2 [/SUP], Fengping Lu[SUP] 1 [/SUP], Lu Feng[SUP] 1 [/SUP], Min Mao[SUP] 1 [/SUP], Lianzhen Lin[SUP] 1 [/SUP], Huanhuan Guo[SUP] 1 [/SUP], Shenglan Yue[SUP] 1 [/SUP], Feifei Wang[SUP] 1 [/SUP], Yan Peng[SUP] 1 [/SUP], Yong Hu[SUP] 1 [/SUP], Zejun Wang[SUP] 4 [/SUP], Jianhong Yu[SUP] 1 [/SUP], Yong Zhang[SUP] 3 [/SUP], Jia Lu[SUP] 4 [/SUP], Haoran Ning[SUP] 1 [/SUP], Huichuan Yang[SUP] 5 [/SUP], Daoxing Fu[SUP] 3 [/SUP], Yanlin He[SUP] 1 3 [/SUP], Dongbo Zhou[SUP] 3 [/SUP], Tao Du[SUP] 3 [/SUP], Kai Duan[SUP] 4 [/SUP], Demei Dong[SUP] 3 [/SUP], Kun Deng[SUP] 1 [/SUP], Xia Zou[SUP] 1 [/SUP], Ya Zhang[SUP] 1 [/SUP], Rong Zhou[SUP] 3 [/SUP], Yang Gao[SUP] 3 [/SUP], Xinxin Zhang[SUP] 6 [/SUP], Xiaoming Yang[SUP] 7 [/SUP]
Affiliations
- PMID: 34230476
- DOI: 10.1038/s41467-021-24230-5
Abstract
To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and test specific antibody responses. The results show that positive rate of IgG antibody against receptor-binding domain of spike protein (RBD-IgG) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the COVID-19 convalescent plasma donors exceeded 70% for 12 months post diagnosis. The level of RBD-IgG decreases with time, with the titer stabilizing at 64.3% of the initial level by the 9th month. Moreover, male plasma donors produce more RBD-IgG than female, and age of the patients positively correlates with the RBD-IgG titer. A strong positive correlation between RBD-IgG and neutralizing antibody titers is also identified. These results facilitate our understanding of SARS-CoV-2-induced immune memory to promote vaccine and therapy development.