tetano
Editor, Senior Moderator
Nat Commun
. 2022 Aug 22;13(1):4830.
doi: 10.1038/s41467-022-32276-2.
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
Qingbo S Wang[SUP] 1 2 [/SUP], Ryuya Edahiro[SUP] 1 3 [/SUP], Ho Namkoong[SUP] 4 [/SUP], Takanori Hasegawa[SUP] 5 [/SUP], Yuya Shirai[SUP] 1 3 [/SUP], Kyuto Sonehara[SUP] 1 6 [/SUP], Hiromu Tanaka[SUP] 7 [/SUP], Ho Lee[SUP] 7 [/SUP], Ryunosuke Saiki[SUP] 8 [/SUP], Takayoshi Hyugaji[SUP] 9 [/SUP], Eigo Shimizu[SUP] 9 [/SUP], Kotoe Katayama[SUP] 9 [/SUP], Masahiro Kanai[SUP] 10 [/SUP], Tatsuhiko Naito[SUP] 1 [/SUP], Noah Sasa[SUP] 1 11 [/SUP], Kenichi Yamamoto[SUP] 1 2 12 [/SUP], Yasuhiro Kato[SUP] 3 13 [/SUP], Takayoshi Morita[SUP] 3 13 [/SUP], Kazuhisa Takahashi[SUP] 14 [/SUP], Norihiro Harada[SUP] 14 [/SUP], Toshio Naito[SUP] 15 [/SUP], Makoto Hiki[SUP] 16 17 [/SUP], Yasushi Matsushita[SUP] 18 [/SUP], Haruhi Takagi[SUP] 14 [/SUP], Masako Ichikawa[SUP] 14 [/SUP], Ai Nakamura[SUP] 14 [/SUP], Sonoko Harada[SUP] 14 19 [/SUP], Yuuki Sandhu[SUP] 14 [/SUP], Hiroki Kabata[SUP] 7 [/SUP], Katsunori Masaki[SUP] 7 [/SUP], Hirofumi Kamata[SUP] 7 [/SUP], Shinnosuke Ikemura[SUP] 7 [/SUP], Shotaro Chubachi[SUP] 7 [/SUP], Satoshi Okamori[SUP] 7 [/SUP], Hideki Terai[SUP] 7 [/SUP], Atsuho Morita[SUP] 7 [/SUP], Takanori Asakura[SUP] 7 [/SUP], Junichi Sasaki[SUP] 20 [/SUP], Hiroshi Morisaki[SUP] 21 [/SUP], Yoshifumi Uwamino[SUP] 22 [/SUP], Kosaku Nanki[SUP] 23 [/SUP], Sho Uchida[SUP] 4 [/SUP], Shunsuke Uno[SUP] 4 [/SUP], Tomoyasu Nishimura[SUP] 4 24 [/SUP], Takashri Ishiguro[SUP] 25 [/SUP], Taisuke Isono[SUP] 25 [/SUP], Shun Shibata[SUP] 25 [/SUP], Yuma Matsui[SUP] 25 [/SUP], Chiaki Hosoda[SUP] 25 [/SUP], Kenji Takano[SUP] 25 [/SUP], Takashi Nishida[SUP] 25 [/SUP], Yoichi Kobayashi[SUP] 25 [/SUP], Yotaro Takaku[SUP] 25 [/SUP], Noboru Takayanagi[SUP] 25 [/SUP], Soichiro Ueda[SUP] 26 [/SUP], Ai Tada[SUP] 26 [/SUP], Masayoshi Miyawaki[SUP] 26 [/SUP], Masaomi Yamamoto[SUP] 26 [/SUP], Eriko Yoshida[SUP] 26 [/SUP], Reina Hayashi[SUP] 26 [/SUP], Tomoki Nagasaka[SUP] 26 [/SUP], Sawako Arai[SUP] 26 [/SUP], Yutaro Kaneko[SUP] 26 [/SUP], Kana Sasaki[SUP] 26 [/SUP], Etsuko Tagaya[SUP] 27 [/SUP], Masatoshi Kawana[SUP] 28 [/SUP], Ken Arimura[SUP] 27 [/SUP], Kunihiko Takahashi[SUP] 5 [/SUP], Tatsuhiko Anzai[SUP] 5 [/SUP], Satoshi Ito[SUP] 5 [/SUP], Akifumi Endo[SUP] 29 [/SUP], Yuji Uchimura[SUP] 30 [/SUP], Yasunari Miyazaki[SUP] 31 [/SUP], Takayuki Honda[SUP] 31 [/SUP], Tomoya Tateishi[SUP] 31 [/SUP], Shuji Tohda[SUP] 32 [/SUP], Naoya Ichimura[SUP] 32 [/SUP], Kazunari Sonobe[SUP] 32 [/SUP], Chihiro Tani Sassa[SUP] 32 [/SUP], Jun Nakajima[SUP] 32 [/SUP], Yasushi Nakano[SUP] 33 [/SUP], Yukiko Nakajima[SUP] 33 [/SUP], Ryusuke Anan[SUP] 33 [/SUP], Ryosuke Arai[SUP] 33 [/SUP], Yuko Kurihara[SUP] 33 [/SUP], Yuko Harada[SUP] 33 [/SUP], Kazumi Nishio[SUP] 33 [/SUP], Tetsuya Ueda[SUP] 34 [/SUP], Masanori Azuma[SUP] 34 [/SUP], Ryuichi Saito[SUP] 34 [/SUP], Toshikatsu Sado[SUP] 34 [/SUP], Yoshimune Miyazaki[SUP] 34 [/SUP], Ryuichi Sato[SUP] 34 [/SUP], Yuki Haruta[SUP] 34 [/SUP], Tadao Nagasaki[SUP] 34 [/SUP], Yoshinori Yasui[SUP] 35 [/SUP], Yoshinori Hasegawa[SUP] 34 [/SUP], Yoshikazu Mutoh[SUP] 36 [/SUP], Tomoki Kimura[SUP] 37 [/SUP], Tomonori Sato[SUP] 37 [/SUP], Reoto Takei[SUP] 37 [/SUP], Satoshi Hagimoto[SUP] 37 [/SUP], Yoichiro Noguchi[SUP] 37 [/SUP], Yasuhiko Yamano[SUP] 37 [/SUP], Hajime Sasano[SUP] 37 [/SUP], Sho Ota[SUP] 37 [/SUP], Yasushi Nakamori[SUP] 38 [/SUP], Kazuhisa Yoshiya[SUP] 38 [/SUP], Fukuki Saito[SUP] 38 [/SUP], Tomoyuki Yoshihara[SUP] 38 [/SUP], Daiki Wada[SUP] 38 [/SUP], Hiromu Iwamura[SUP] 38 [/SUP], Syuji Kanayama[SUP] 38 [/SUP], Shuhei Maruyama[SUP] 38 [/SUP], Takashi Yoshiyama[SUP] 39 [/SUP], Ken Ohta[SUP] 39 [/SUP], Hiroyuki Kokuto[SUP] 39 [/SUP], Hideo Ogata[SUP] 39 [/SUP], Yoshiaki Tanaka[SUP] 39 [/SUP], Kenichi Arakawa[SUP] 39 [/SUP], Masafumi Shimoda[SUP] 39 [/SUP], Takeshi Osawa[SUP] 39 [/SUP], Hiroki Tateno[SUP] 40 [/SUP], Isano Hase[SUP] 40 [/SUP], Shuichi Yoshida[SUP] 40 [/SUP], Shoji Suzuki[SUP] 40 [/SUP], Miki Kawada[SUP] 41 [/SUP], Hirohisa Horinouchi[SUP] 42 [/SUP], Fumitake Saito[SUP] 43 [/SUP], Keiko Mitamura[SUP] 44 [/SUP], Masao Hagihara[SUP] 45 [/SUP], Junichi Ochi[SUP] 43 [/SUP], Tomoyuki Uchida[SUP] 45 [/SUP], Rie Baba[SUP] 46 [/SUP], Daisuke Arai[SUP] 46 [/SUP], Takayuki Ogura[SUP] 46 [/SUP], Hidenori Takahashi[SUP] 46 [/SUP], Shigehiro Hagiwara[SUP] 46 [/SUP], Genta Nagao[SUP] 46 [/SUP], Shunichiro Konishi[SUP] 46 [/SUP], Ichiro Nakachi[SUP] 46 [/SUP], Koji Murakami[SUP] 47 [/SUP], Mitsuhiro Yamada[SUP] 47 [/SUP], Hisatoshi Sugiura[SUP] 47 [/SUP], Hirohito Sano[SUP] 47 [/SUP], Shuichiro Matsumoto[SUP] 47 [/SUP], Nozomu Kimura[SUP] 47 [/SUP], Yoshinao Ono[SUP] 47 [/SUP], Hiroaki Baba[SUP] 48 [/SUP], Yusuke Suzuki[SUP] 49 [/SUP], Sohei Nakayama[SUP] 49 [/SUP], Keita Masuzawa[SUP] 49 [/SUP], Shinichi Namba[SUP] 1 [/SUP], Takayuki Shiroyama[SUP] 3 [/SUP], Yoshimi Noda[SUP] 3 [/SUP], Takayuki Niitsu[SUP] 3 [/SUP], Yuichi Adachi[SUP] 3 [/SUP], Takatoshi Enomoto[SUP] 3 [/SUP], Saori Amiya[SUP] 3 [/SUP], Reina Hara[SUP] 3 [/SUP], Yuta Yamaguchi[SUP] 3 13 [/SUP], Teruaki Murakami[SUP] 3 13 [/SUP], Tomoki Kuge[SUP] 3 [/SUP], Kinnosuke Matsumoto[SUP] 3 [/SUP], Yuji Yamamoto[SUP] 3 [/SUP], Makoto Yamamoto[SUP] 3 [/SUP], Midori Yoneda[SUP] 3 [/SUP], Kazunori Tomono[SUP] 50 [/SUP], Kazuto Kato[SUP] 51 [/SUP], Haruhiko Hirata[SUP] 3 [/SUP], Yoshito Takeda[SUP] 3 [/SUP], Hidefumi Koh[SUP] 52 [/SUP], Tadashi Manabe[SUP] 52 [/SUP], Yohei Funatsu[SUP] 52 [/SUP], Fumimaro Ito[SUP] 52 [/SUP], Takahiro Fukui[SUP] 52 [/SUP], Keisuke Shinozuka[SUP] 52 [/SUP], Sumiko Kohashi[SUP] 52 [/SUP], Masatoshi Miyazaki[SUP] 52 [/SUP], Tomohisa Shoko[SUP] 53 [/SUP], Mitsuaki Kojima[SUP] 53 [/SUP], Tomohiro Adachi[SUP] 53 [/SUP], Motonao Ishikawa[SUP] 54 [/SUP], Kenichiro Takahashi[SUP] 55 [/SUP], Takashi Inoue[SUP] 56 [/SUP], Toshiyuki Hirano[SUP] 56 [/SUP], Keigo Kobayashi[SUP] 56 [/SUP], Hatsuyo Takaoka[SUP] 56 [/SUP], Kazuyoshi Watanabe[SUP] 57 [/SUP], Naoki Miyazawa[SUP] 58 [/SUP], Yasuhiro Kimura[SUP] 58 [/SUP], Reiko Sado[SUP] 58 [/SUP], Hideyasu Sugimoto[SUP] 58 [/SUP], Akane Kamiya[SUP] 59 [/SUP], Naota Kuwahara[SUP] 60 [/SUP], Akiko Fujiwara[SUP] 60 [/SUP], Tomohiro Matsunaga[SUP] 60 [/SUP], Yoko Sato[SUP] 60 [/SUP], Takenori Okada[SUP] 60 [/SUP], Yoshihiro Hirai[SUP] 61 [/SUP], Hidetoshi Kawashima[SUP] 61 [/SUP], Atsuya Narita[SUP] 61 [/SUP], Kazuki Niwa[SUP] 62 [/SUP], Yoshiyuki Sekikawa[SUP] 62 [/SUP], Koichi Nishi[SUP] 63 [/SUP], Masaru Nishitsuji[SUP] 63 [/SUP], Mayuko Tani[SUP] 63 [/SUP], Junya Suzuki[SUP] 63 [/SUP], Hiroki Nakatsumi[SUP] 63 [/SUP], Takashi Ogura[SUP] 64 [/SUP], Hideya Kitamura[SUP] 64 [/SUP], Eri Hagiwara[SUP] 64 [/SUP], Kota Murohashi[SUP] 64 [/SUP], Hiroko Okabayashi[SUP] 64 [/SUP], Takao Mochimaru[SUP] 65 66 [/SUP], Shigenari Nukaga[SUP] 65 [/SUP], Ryosuke Satomi[SUP] 65 [/SUP], Yoshitaka Oyamada[SUP] 65 66 [/SUP], Nobuaki Mori[SUP] 67 [/SUP], Tomoya Baba[SUP] 68 [/SUP], Yasutaka Fukui[SUP] 68 [/SUP], Mitsuru Odate[SUP] 68 [/SUP], Shuko Mashimo[SUP] 68 [/SUP], Yasushi Makino[SUP] 68 [/SUP], Kazuma Yagi[SUP] 69 [/SUP], Mizuha Hashiguchi[SUP] 69 [/SUP], Junko Kagyo[SUP] 69 [/SUP], Tetsuya Shiomi[SUP] 69 [/SUP], Satoshi Fuke[SUP] 70 [/SUP], Hiroshi Saito[SUP] 70 [/SUP], Tomoya Tsuchida[SUP] 71 [/SUP], Shigeki Fujitani[SUP] 72 [/SUP], Mumon Takita[SUP] 72 [/SUP], Daiki Morikawa[SUP] 72 [/SUP], Toru Yoshida[SUP] 72 [/SUP], Takehiro Izumo[SUP] 73 [/SUP], Minoru Inomata[SUP] 73 [/SUP], Naoyuki Kuse[SUP] 73 [/SUP], Nobuyasu Awano[SUP] 73 [/SUP], Mari Tone[SUP] 73 [/SUP], Akihiro Ito[SUP] 74 [/SUP], Yoshihiko Nakamura[SUP] 75 [/SUP], Kota Hoshino[SUP] 75 [/SUP], Junichi Maruyama[SUP] 75 [/SUP], Hiroyasu Ishikura[SUP] 75 [/SUP], Tohru Takata[SUP] 76 [/SUP], Toshio Odani[SUP] 77 [/SUP], Masaru Amishima[SUP] 78 [/SUP], Takeshi Hattori[SUP] 78 [/SUP], Yasuo Shichinohe[SUP] 79 [/SUP], Takashi Kagaya[SUP] 80 [/SUP], Toshiyuki Kita[SUP] 80 [/SUP], Kazuhide Ohta[SUP] 80 [/SUP], Satoru Sakagami[SUP] 80 [/SUP], Kiyoshi Koshida[SUP] 80 [/SUP], Kentaro Hayashi[SUP] 81 [/SUP], Tetsuo Shimizu[SUP] 81 [/SUP], Yutaka Kozu[SUP] 81 [/SUP], Hisato Hiranuma[SUP] 81 [/SUP], Yasuhiro Gon[SUP] 81 [/SUP], Namiki Izumi[SUP] 82 [/SUP], Kaoru Nagata[SUP] 82 [/SUP], Ken Ueda[SUP] 82 [/SUP], Reiko Taki[SUP] 82 [/SUP], Satoko Hanada[SUP] 82 [/SUP], Kodai Kawamura[SUP] 83 [/SUP], Kazuya Ichikado[SUP] 83 [/SUP], Kenta Nishiyama[SUP] 83 [/SUP], Hiroyuki Muranaka[SUP] 83 [/SUP], Kazunori Nakamura[SUP] 83 [/SUP], Naozumi Hashimoto[SUP] 84 [/SUP], Keiko Wakahara[SUP] 84 [/SUP], Sakamoto Koji[SUP] 84 [/SUP], Norihito Omote[SUP] 84 [/SUP], Akira Ando[SUP] 84 [/SUP], Nobuhiro Kodama[SUP] 85 [/SUP], Yasunari Kaneyama[SUP] 85 [/SUP], Shunsuke Maeda[SUP] 85 [/SUP], Takashige Kuraki[SUP] 86 [/SUP], Takemasa Matsumoto[SUP] 86 [/SUP], Koutaro Yokote[SUP] 87 [/SUP], Taka-Aki Nakada[SUP] 88 [/SUP], Ryuzo Abe[SUP] 88 [/SUP], Taku Oshima[SUP] 88 [/SUP], Tadanaga Shimada[SUP] 88 [/SUP], Masahiro Harada[SUP] 89 [/SUP], Takeshi Takahashi[SUP] 89 [/SUP], Hiroshi Ono[SUP] 89 [/SUP], Toshihiro Sakurai[SUP] 89 [/SUP], Takayuki Shibusawa[SUP] 89 [/SUP], Yoshifumi Kimizuka[SUP] 90 [/SUP], Akihiko Kawana[SUP] 90 [/SUP], Tomoya Sano[SUP] 90 [/SUP], Chie Watanabe[SUP] 90 [/SUP], Ryohei Suematsu[SUP] 90 [/SUP], Hisako Sageshima[SUP] 91 [/SUP], Ayumi Yoshifuji[SUP] 92 [/SUP], Kazuto Ito[SUP] 92 [/SUP], Saeko Takahashi[SUP] 93 [/SUP], Kota Ishioka[SUP] 93 [/SUP], Morio Nakamura[SUP] 93 [/SUP], Makoto Masuda[SUP] 94 [/SUP], Aya Wakabayashi[SUP] 94 [/SUP], Hiroki Watanabe[SUP] 94 [/SUP], Suguru Ueda[SUP] 94 [/SUP], Masanori Nishikawa[SUP] 94 [/SUP], Yusuke Chihara[SUP] 95 [/SUP], Mayumi Takeuchi[SUP] 95 [/SUP], Keisuke Onoi[SUP] 95 [/SUP], Jun Shinozuka[SUP] 95 [/SUP], Atsushi Sueyoshi[SUP] 95 [/SUP], Yoji Nagasaki[SUP] 96 [/SUP], Masaki Okamoto[SUP] 97 98 [/SUP], Sayoko Ishihara[SUP] 99 [/SUP], Masatoshi Shimo[SUP] 99 [/SUP], Yoshihisa Tokunaga[SUP] 97 98 [/SUP], Yu Kusaka[SUP] 100 [/SUP], Takehiko Ohba[SUP] 100 [/SUP], Susumu Isogai[SUP] 100 [/SUP], Aki Ogawa[SUP] 100 [/SUP], Takuya Inoue[SUP] 100 [/SUP], Satoru Fukuyama[SUP] 101 [/SUP], Yoshihiro Eriguchi[SUP] 102 [/SUP], Akiko Yonekawa[SUP] 102 [/SUP], Keiko Kan-O[SUP] 101 [/SUP], Koichiro Matsumoto[SUP] 101 [/SUP], Kensuke Kanaoka[SUP] 103 [/SUP], Shoichi Ihara[SUP] 103 [/SUP], Kiyoshi Komuta[SUP] 103 [/SUP], Yoshiaki Inoue[SUP] 104 [/SUP], Shigeru Chiba[SUP] 105 [/SUP], Kunihiro Yamagata[SUP] 106 [/SUP], Yuji Hiramatsu[SUP] 107 [/SUP], Hirayasu Kai[SUP] 106 [/SUP], Koichiro Asano[SUP] 108 [/SUP], Tsuyoshi Oguma[SUP] 108 [/SUP], Yoko Ito[SUP] 108 [/SUP], Satoru Hashimoto[SUP] 109 [/SUP], Masaki Yamasaki[SUP] 109 [/SUP], Yu Kasamatsu[SUP] 110 [/SUP], Yuko Komase[SUP] 111 [/SUP], Naoya Hida[SUP] 111 [/SUP], Takahiro Tsuburai[SUP] 111 [/SUP], Baku Oyama[SUP] 111 [/SUP], Minoru Takada[SUP] 112 [/SUP], Hidenori Kanda[SUP] 112 [/SUP], Yuichiro Kitagawa[SUP] 113 [/SUP], Tetsuya Fukuta[SUP] 113 [/SUP], Takahito Miyake[SUP] 113 [/SUP], Shozo Yoshida[SUP] 113 [/SUP], Shinji Ogura[SUP] 113 [/SUP], Shinji Abe[SUP] 114 [/SUP], Yuta Kono[SUP] 114 [/SUP], Yuki Togashi[SUP] 114 [/SUP], Hiroyuki Takoi[SUP] 114 [/SUP], Ryota Kikuchi[SUP] 114 [/SUP], Shinichi Ogawa[SUP] 115 [/SUP], Tomouki Ogata[SUP] 115 [/SUP], Shoichiro Ishihara[SUP] 115 [/SUP], Arihiko Kanehiro[SUP] 116 117 [/SUP], Shinji Ozaki[SUP] 116 [/SUP], Yasuko Fuchimoto[SUP] 116 [/SUP], Sae Wada[SUP] 116 [/SUP], Nobukazu Fujimoto[SUP] 116 [/SUP], Kei Nishiyama[SUP] 118 [/SUP], Mariko Terashima[SUP] 119 [/SUP], Satoru Beppu[SUP] 119 [/SUP], Kosuke Yoshida[SUP] 119 [/SUP], Osamu Narumoto[SUP] 120 [/SUP], Hideaki Nagai[SUP] 120 [/SUP], Nobuharu Ooshima[SUP] 120 [/SUP], Mitsuru Motegi[SUP] 121 [/SUP], Akira Umeda[SUP] 122 [/SUP], Kazuya Miyagawa[SUP] 123 [/SUP], Hisato Shimada[SUP] 124 [/SUP], Mayu Endo[SUP] 125 [/SUP], Yoshiyuki Ohira[SUP] 122 [/SUP], Masafumi Watanabe[SUP] 126 [/SUP], Sumito Inoue[SUP] 126 [/SUP], Akira Igarashi[SUP] 126 [/SUP], Masamichi Sato[SUP] 126 [/SUP], Hironori Sagara[SUP] 127 [/SUP], Akihiko Tanaka[SUP] 127 [/SUP], Shin Ohta[SUP] 127 [/SUP], Tomoyuki Kimura[SUP] 127 [/SUP], Yoko Shibata[SUP] 128 [/SUP], Yoshinori Tanino[SUP] 128 [/SUP], Takefumi Nikaido[SUP] 128 [/SUP], Hiroyuki Minemura[SUP] 128 [/SUP], Yuki Sato[SUP] 128 [/SUP], Yuichiro Yamada[SUP] 129 [/SUP], Takuya Hashino[SUP] 129 [/SUP], Masato Shinoki[SUP] 129 [/SUP], Hajime Iwagoe[SUP] 130 [/SUP], Hiroshi Takahashi[SUP] 131 [/SUP], Kazuhiko Fujii[SUP] 131 [/SUP], Hiroto Kishi[SUP] 131 [/SUP], Masayuki Kanai[SUP] 132 [/SUP], Tomonori Imamura[SUP] 132 [/SUP], Tatsuya Yamashita[SUP] 132 [/SUP], Masakiyo Yatomi[SUP] 133 [/SUP], Toshitaka Maeno[SUP] 133 [/SUP], Shinichi Hayashi[SUP] 134 [/SUP], Mai Takahashi[SUP] 134 [/SUP], Mizuki Kuramochi[SUP] 134 [/SUP], Isamu Kamimaki[SUP] 134 [/SUP], Yoshiteru Tominaga[SUP] 134 [/SUP], Tomoo Ishii[SUP] 135 [/SUP], Mitsuyoshi Utsugi[SUP] 136 [/SUP], Akihiro Ono[SUP] 136 [/SUP], Toru Tanaka[SUP] 137 [/SUP], Takeru Kashiwada[SUP] 137 [/SUP], Kazue Fujita[SUP] 137 [/SUP], Yoshinobu Saito[SUP] 137 [/SUP], Masahiro Seike[SUP] 137 [/SUP], Hiroko Watanabe[SUP] 138 [/SUP], Hiroto Matsuse[SUP] 139 [/SUP], Norio Kodaka[SUP] 139 [/SUP], Chihiro Nakano[SUP] 139 [/SUP], Takeshi Oshio[SUP] 139 [/SUP], Takatomo Hirouchi[SUP] 139 [/SUP], Shohei Makino[SUP] 140 [/SUP], Moritoki Egi[SUP] 140 [/SUP], Yosuke Omae[SUP] 141 [/SUP], Yasuhito Nannya[SUP] 8 [/SUP], Takafumi Ueno[SUP] 142 [/SUP], Tomomi Takano[SUP] 143 [/SUP], Kazuhiko Katayama[SUP] 144 [/SUP], Masumi Ai[SUP] 145 [/SUP], Atsushi Kumanogoh[SUP] 3 6 13 146 [/SUP], Toshiro Sato[SUP] 147 [/SUP], Naoki Hasegawa[SUP] 4 [/SUP], Katsushi Tokunaga[SUP] 141 [/SUP], Makoto Ishii[SUP] 7 [/SUP], Ryuji Koike[SUP] 148 [/SUP], Yuko Kitagawa[SUP] 149 [/SUP], Akinori Kimura[SUP] 150 [/SUP], Seiya Imoto[SUP] 9 [/SUP], Satoru Miyano[SUP] #[/SUP][SUP] 5 [/SUP], Seishi Ogawa[SUP] #[/SUP][SUP] 8 151 152 [/SUP], Takanori Kanai[SUP] #[/SUP][SUP] 24 153 [/SUP], Koichi Fukunaga[SUP] #[/SUP][SUP] 7 [/SUP], Yukinori Okada[SUP] #[/SUP][SUP] 154 155 156 157 158 159 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.
. 2022 Aug 22;13(1):4830.
doi: 10.1038/s41467-022-32276-2.
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
Qingbo S Wang[SUP] 1 2 [/SUP], Ryuya Edahiro[SUP] 1 3 [/SUP], Ho Namkoong[SUP] 4 [/SUP], Takanori Hasegawa[SUP] 5 [/SUP], Yuya Shirai[SUP] 1 3 [/SUP], Kyuto Sonehara[SUP] 1 6 [/SUP], Hiromu Tanaka[SUP] 7 [/SUP], Ho Lee[SUP] 7 [/SUP], Ryunosuke Saiki[SUP] 8 [/SUP], Takayoshi Hyugaji[SUP] 9 [/SUP], Eigo Shimizu[SUP] 9 [/SUP], Kotoe Katayama[SUP] 9 [/SUP], Masahiro Kanai[SUP] 10 [/SUP], Tatsuhiko Naito[SUP] 1 [/SUP], Noah Sasa[SUP] 1 11 [/SUP], Kenichi Yamamoto[SUP] 1 2 12 [/SUP], Yasuhiro Kato[SUP] 3 13 [/SUP], Takayoshi Morita[SUP] 3 13 [/SUP], Kazuhisa Takahashi[SUP] 14 [/SUP], Norihiro Harada[SUP] 14 [/SUP], Toshio Naito[SUP] 15 [/SUP], Makoto Hiki[SUP] 16 17 [/SUP], Yasushi Matsushita[SUP] 18 [/SUP], Haruhi Takagi[SUP] 14 [/SUP], Masako Ichikawa[SUP] 14 [/SUP], Ai Nakamura[SUP] 14 [/SUP], Sonoko Harada[SUP] 14 19 [/SUP], Yuuki Sandhu[SUP] 14 [/SUP], Hiroki Kabata[SUP] 7 [/SUP], Katsunori Masaki[SUP] 7 [/SUP], Hirofumi Kamata[SUP] 7 [/SUP], Shinnosuke Ikemura[SUP] 7 [/SUP], Shotaro Chubachi[SUP] 7 [/SUP], Satoshi Okamori[SUP] 7 [/SUP], Hideki Terai[SUP] 7 [/SUP], Atsuho Morita[SUP] 7 [/SUP], Takanori Asakura[SUP] 7 [/SUP], Junichi Sasaki[SUP] 20 [/SUP], Hiroshi Morisaki[SUP] 21 [/SUP], Yoshifumi Uwamino[SUP] 22 [/SUP], Kosaku Nanki[SUP] 23 [/SUP], Sho Uchida[SUP] 4 [/SUP], Shunsuke Uno[SUP] 4 [/SUP], Tomoyasu Nishimura[SUP] 4 24 [/SUP], Takashri Ishiguro[SUP] 25 [/SUP], Taisuke Isono[SUP] 25 [/SUP], Shun Shibata[SUP] 25 [/SUP], Yuma Matsui[SUP] 25 [/SUP], Chiaki Hosoda[SUP] 25 [/SUP], Kenji Takano[SUP] 25 [/SUP], Takashi Nishida[SUP] 25 [/SUP], Yoichi Kobayashi[SUP] 25 [/SUP], Yotaro Takaku[SUP] 25 [/SUP], Noboru Takayanagi[SUP] 25 [/SUP], Soichiro Ueda[SUP] 26 [/SUP], Ai Tada[SUP] 26 [/SUP], Masayoshi Miyawaki[SUP] 26 [/SUP], Masaomi Yamamoto[SUP] 26 [/SUP], Eriko Yoshida[SUP] 26 [/SUP], Reina Hayashi[SUP] 26 [/SUP], Tomoki Nagasaka[SUP] 26 [/SUP], Sawako Arai[SUP] 26 [/SUP], Yutaro Kaneko[SUP] 26 [/SUP], Kana Sasaki[SUP] 26 [/SUP], Etsuko Tagaya[SUP] 27 [/SUP], Masatoshi Kawana[SUP] 28 [/SUP], Ken Arimura[SUP] 27 [/SUP], Kunihiko Takahashi[SUP] 5 [/SUP], Tatsuhiko Anzai[SUP] 5 [/SUP], Satoshi Ito[SUP] 5 [/SUP], Akifumi Endo[SUP] 29 [/SUP], Yuji Uchimura[SUP] 30 [/SUP], Yasunari Miyazaki[SUP] 31 [/SUP], Takayuki Honda[SUP] 31 [/SUP], Tomoya Tateishi[SUP] 31 [/SUP], Shuji Tohda[SUP] 32 [/SUP], Naoya Ichimura[SUP] 32 [/SUP], Kazunari Sonobe[SUP] 32 [/SUP], Chihiro Tani Sassa[SUP] 32 [/SUP], Jun Nakajima[SUP] 32 [/SUP], Yasushi Nakano[SUP] 33 [/SUP], Yukiko Nakajima[SUP] 33 [/SUP], Ryusuke Anan[SUP] 33 [/SUP], Ryosuke Arai[SUP] 33 [/SUP], Yuko Kurihara[SUP] 33 [/SUP], Yuko Harada[SUP] 33 [/SUP], Kazumi Nishio[SUP] 33 [/SUP], Tetsuya Ueda[SUP] 34 [/SUP], Masanori Azuma[SUP] 34 [/SUP], Ryuichi Saito[SUP] 34 [/SUP], Toshikatsu Sado[SUP] 34 [/SUP], Yoshimune Miyazaki[SUP] 34 [/SUP], Ryuichi Sato[SUP] 34 [/SUP], Yuki Haruta[SUP] 34 [/SUP], Tadao Nagasaki[SUP] 34 [/SUP], Yoshinori Yasui[SUP] 35 [/SUP], Yoshinori Hasegawa[SUP] 34 [/SUP], Yoshikazu Mutoh[SUP] 36 [/SUP], Tomoki Kimura[SUP] 37 [/SUP], Tomonori Sato[SUP] 37 [/SUP], Reoto Takei[SUP] 37 [/SUP], Satoshi Hagimoto[SUP] 37 [/SUP], Yoichiro Noguchi[SUP] 37 [/SUP], Yasuhiko Yamano[SUP] 37 [/SUP], Hajime Sasano[SUP] 37 [/SUP], Sho Ota[SUP] 37 [/SUP], Yasushi Nakamori[SUP] 38 [/SUP], Kazuhisa Yoshiya[SUP] 38 [/SUP], Fukuki Saito[SUP] 38 [/SUP], Tomoyuki Yoshihara[SUP] 38 [/SUP], Daiki Wada[SUP] 38 [/SUP], Hiromu Iwamura[SUP] 38 [/SUP], Syuji Kanayama[SUP] 38 [/SUP], Shuhei Maruyama[SUP] 38 [/SUP], Takashi Yoshiyama[SUP] 39 [/SUP], Ken Ohta[SUP] 39 [/SUP], Hiroyuki Kokuto[SUP] 39 [/SUP], Hideo Ogata[SUP] 39 [/SUP], Yoshiaki Tanaka[SUP] 39 [/SUP], Kenichi Arakawa[SUP] 39 [/SUP], Masafumi Shimoda[SUP] 39 [/SUP], Takeshi Osawa[SUP] 39 [/SUP], Hiroki Tateno[SUP] 40 [/SUP], Isano Hase[SUP] 40 [/SUP], Shuichi Yoshida[SUP] 40 [/SUP], Shoji Suzuki[SUP] 40 [/SUP], Miki Kawada[SUP] 41 [/SUP], Hirohisa Horinouchi[SUP] 42 [/SUP], Fumitake Saito[SUP] 43 [/SUP], Keiko Mitamura[SUP] 44 [/SUP], Masao Hagihara[SUP] 45 [/SUP], Junichi Ochi[SUP] 43 [/SUP], Tomoyuki Uchida[SUP] 45 [/SUP], Rie Baba[SUP] 46 [/SUP], Daisuke Arai[SUP] 46 [/SUP], Takayuki Ogura[SUP] 46 [/SUP], Hidenori Takahashi[SUP] 46 [/SUP], Shigehiro Hagiwara[SUP] 46 [/SUP], Genta Nagao[SUP] 46 [/SUP], Shunichiro Konishi[SUP] 46 [/SUP], Ichiro Nakachi[SUP] 46 [/SUP], Koji Murakami[SUP] 47 [/SUP], Mitsuhiro Yamada[SUP] 47 [/SUP], Hisatoshi Sugiura[SUP] 47 [/SUP], Hirohito Sano[SUP] 47 [/SUP], Shuichiro Matsumoto[SUP] 47 [/SUP], Nozomu Kimura[SUP] 47 [/SUP], Yoshinao Ono[SUP] 47 [/SUP], Hiroaki Baba[SUP] 48 [/SUP], Yusuke Suzuki[SUP] 49 [/SUP], Sohei Nakayama[SUP] 49 [/SUP], Keita Masuzawa[SUP] 49 [/SUP], Shinichi Namba[SUP] 1 [/SUP], Takayuki Shiroyama[SUP] 3 [/SUP], Yoshimi Noda[SUP] 3 [/SUP], Takayuki Niitsu[SUP] 3 [/SUP], Yuichi Adachi[SUP] 3 [/SUP], Takatoshi Enomoto[SUP] 3 [/SUP], Saori Amiya[SUP] 3 [/SUP], Reina Hara[SUP] 3 [/SUP], Yuta Yamaguchi[SUP] 3 13 [/SUP], Teruaki Murakami[SUP] 3 13 [/SUP], Tomoki Kuge[SUP] 3 [/SUP], Kinnosuke Matsumoto[SUP] 3 [/SUP], Yuji Yamamoto[SUP] 3 [/SUP], Makoto Yamamoto[SUP] 3 [/SUP], Midori Yoneda[SUP] 3 [/SUP], Kazunori Tomono[SUP] 50 [/SUP], Kazuto Kato[SUP] 51 [/SUP], Haruhiko Hirata[SUP] 3 [/SUP], Yoshito Takeda[SUP] 3 [/SUP], Hidefumi Koh[SUP] 52 [/SUP], Tadashi Manabe[SUP] 52 [/SUP], Yohei Funatsu[SUP] 52 [/SUP], Fumimaro Ito[SUP] 52 [/SUP], Takahiro Fukui[SUP] 52 [/SUP], Keisuke Shinozuka[SUP] 52 [/SUP], Sumiko Kohashi[SUP] 52 [/SUP], Masatoshi Miyazaki[SUP] 52 [/SUP], Tomohisa Shoko[SUP] 53 [/SUP], Mitsuaki Kojima[SUP] 53 [/SUP], Tomohiro Adachi[SUP] 53 [/SUP], Motonao Ishikawa[SUP] 54 [/SUP], Kenichiro Takahashi[SUP] 55 [/SUP], Takashi Inoue[SUP] 56 [/SUP], Toshiyuki Hirano[SUP] 56 [/SUP], Keigo Kobayashi[SUP] 56 [/SUP], Hatsuyo Takaoka[SUP] 56 [/SUP], Kazuyoshi Watanabe[SUP] 57 [/SUP], Naoki Miyazawa[SUP] 58 [/SUP], Yasuhiro Kimura[SUP] 58 [/SUP], Reiko Sado[SUP] 58 [/SUP], Hideyasu Sugimoto[SUP] 58 [/SUP], Akane Kamiya[SUP] 59 [/SUP], Naota Kuwahara[SUP] 60 [/SUP], Akiko Fujiwara[SUP] 60 [/SUP], Tomohiro Matsunaga[SUP] 60 [/SUP], Yoko Sato[SUP] 60 [/SUP], Takenori Okada[SUP] 60 [/SUP], Yoshihiro Hirai[SUP] 61 [/SUP], Hidetoshi Kawashima[SUP] 61 [/SUP], Atsuya Narita[SUP] 61 [/SUP], Kazuki Niwa[SUP] 62 [/SUP], Yoshiyuki Sekikawa[SUP] 62 [/SUP], Koichi Nishi[SUP] 63 [/SUP], Masaru Nishitsuji[SUP] 63 [/SUP], Mayuko Tani[SUP] 63 [/SUP], Junya Suzuki[SUP] 63 [/SUP], Hiroki Nakatsumi[SUP] 63 [/SUP], Takashi Ogura[SUP] 64 [/SUP], Hideya Kitamura[SUP] 64 [/SUP], Eri Hagiwara[SUP] 64 [/SUP], Kota Murohashi[SUP] 64 [/SUP], Hiroko Okabayashi[SUP] 64 [/SUP], Takao Mochimaru[SUP] 65 66 [/SUP], Shigenari Nukaga[SUP] 65 [/SUP], Ryosuke Satomi[SUP] 65 [/SUP], Yoshitaka Oyamada[SUP] 65 66 [/SUP], Nobuaki Mori[SUP] 67 [/SUP], Tomoya Baba[SUP] 68 [/SUP], Yasutaka Fukui[SUP] 68 [/SUP], Mitsuru Odate[SUP] 68 [/SUP], Shuko Mashimo[SUP] 68 [/SUP], Yasushi Makino[SUP] 68 [/SUP], Kazuma Yagi[SUP] 69 [/SUP], Mizuha Hashiguchi[SUP] 69 [/SUP], Junko Kagyo[SUP] 69 [/SUP], Tetsuya Shiomi[SUP] 69 [/SUP], Satoshi Fuke[SUP] 70 [/SUP], Hiroshi Saito[SUP] 70 [/SUP], Tomoya Tsuchida[SUP] 71 [/SUP], Shigeki Fujitani[SUP] 72 [/SUP], Mumon Takita[SUP] 72 [/SUP], Daiki Morikawa[SUP] 72 [/SUP], Toru Yoshida[SUP] 72 [/SUP], Takehiro Izumo[SUP] 73 [/SUP], Minoru Inomata[SUP] 73 [/SUP], Naoyuki Kuse[SUP] 73 [/SUP], Nobuyasu Awano[SUP] 73 [/SUP], Mari Tone[SUP] 73 [/SUP], Akihiro Ito[SUP] 74 [/SUP], Yoshihiko Nakamura[SUP] 75 [/SUP], Kota Hoshino[SUP] 75 [/SUP], Junichi Maruyama[SUP] 75 [/SUP], Hiroyasu Ishikura[SUP] 75 [/SUP], Tohru Takata[SUP] 76 [/SUP], Toshio Odani[SUP] 77 [/SUP], Masaru Amishima[SUP] 78 [/SUP], Takeshi Hattori[SUP] 78 [/SUP], Yasuo Shichinohe[SUP] 79 [/SUP], Takashi Kagaya[SUP] 80 [/SUP], Toshiyuki Kita[SUP] 80 [/SUP], Kazuhide Ohta[SUP] 80 [/SUP], Satoru Sakagami[SUP] 80 [/SUP], Kiyoshi Koshida[SUP] 80 [/SUP], Kentaro Hayashi[SUP] 81 [/SUP], Tetsuo Shimizu[SUP] 81 [/SUP], Yutaka Kozu[SUP] 81 [/SUP], Hisato Hiranuma[SUP] 81 [/SUP], Yasuhiro Gon[SUP] 81 [/SUP], Namiki Izumi[SUP] 82 [/SUP], Kaoru Nagata[SUP] 82 [/SUP], Ken Ueda[SUP] 82 [/SUP], Reiko Taki[SUP] 82 [/SUP], Satoko Hanada[SUP] 82 [/SUP], Kodai Kawamura[SUP] 83 [/SUP], Kazuya Ichikado[SUP] 83 [/SUP], Kenta Nishiyama[SUP] 83 [/SUP], Hiroyuki Muranaka[SUP] 83 [/SUP], Kazunori Nakamura[SUP] 83 [/SUP], Naozumi Hashimoto[SUP] 84 [/SUP], Keiko Wakahara[SUP] 84 [/SUP], Sakamoto Koji[SUP] 84 [/SUP], Norihito Omote[SUP] 84 [/SUP], Akira Ando[SUP] 84 [/SUP], Nobuhiro Kodama[SUP] 85 [/SUP], Yasunari Kaneyama[SUP] 85 [/SUP], Shunsuke Maeda[SUP] 85 [/SUP], Takashige Kuraki[SUP] 86 [/SUP], Takemasa Matsumoto[SUP] 86 [/SUP], Koutaro Yokote[SUP] 87 [/SUP], Taka-Aki Nakada[SUP] 88 [/SUP], Ryuzo Abe[SUP] 88 [/SUP], Taku Oshima[SUP] 88 [/SUP], Tadanaga Shimada[SUP] 88 [/SUP], Masahiro Harada[SUP] 89 [/SUP], Takeshi Takahashi[SUP] 89 [/SUP], Hiroshi Ono[SUP] 89 [/SUP], Toshihiro Sakurai[SUP] 89 [/SUP], Takayuki Shibusawa[SUP] 89 [/SUP], Yoshifumi Kimizuka[SUP] 90 [/SUP], Akihiko Kawana[SUP] 90 [/SUP], Tomoya Sano[SUP] 90 [/SUP], Chie Watanabe[SUP] 90 [/SUP], Ryohei Suematsu[SUP] 90 [/SUP], Hisako Sageshima[SUP] 91 [/SUP], Ayumi Yoshifuji[SUP] 92 [/SUP], Kazuto Ito[SUP] 92 [/SUP], Saeko Takahashi[SUP] 93 [/SUP], Kota Ishioka[SUP] 93 [/SUP], Morio Nakamura[SUP] 93 [/SUP], Makoto Masuda[SUP] 94 [/SUP], Aya Wakabayashi[SUP] 94 [/SUP], Hiroki Watanabe[SUP] 94 [/SUP], Suguru Ueda[SUP] 94 [/SUP], Masanori Nishikawa[SUP] 94 [/SUP], Yusuke Chihara[SUP] 95 [/SUP], Mayumi Takeuchi[SUP] 95 [/SUP], Keisuke Onoi[SUP] 95 [/SUP], Jun Shinozuka[SUP] 95 [/SUP], Atsushi Sueyoshi[SUP] 95 [/SUP], Yoji Nagasaki[SUP] 96 [/SUP], Masaki Okamoto[SUP] 97 98 [/SUP], Sayoko Ishihara[SUP] 99 [/SUP], Masatoshi Shimo[SUP] 99 [/SUP], Yoshihisa Tokunaga[SUP] 97 98 [/SUP], Yu Kusaka[SUP] 100 [/SUP], Takehiko Ohba[SUP] 100 [/SUP], Susumu Isogai[SUP] 100 [/SUP], Aki Ogawa[SUP] 100 [/SUP], Takuya Inoue[SUP] 100 [/SUP], Satoru Fukuyama[SUP] 101 [/SUP], Yoshihiro Eriguchi[SUP] 102 [/SUP], Akiko Yonekawa[SUP] 102 [/SUP], Keiko Kan-O[SUP] 101 [/SUP], Koichiro Matsumoto[SUP] 101 [/SUP], Kensuke Kanaoka[SUP] 103 [/SUP], Shoichi Ihara[SUP] 103 [/SUP], Kiyoshi Komuta[SUP] 103 [/SUP], Yoshiaki Inoue[SUP] 104 [/SUP], Shigeru Chiba[SUP] 105 [/SUP], Kunihiro Yamagata[SUP] 106 [/SUP], Yuji Hiramatsu[SUP] 107 [/SUP], Hirayasu Kai[SUP] 106 [/SUP], Koichiro Asano[SUP] 108 [/SUP], Tsuyoshi Oguma[SUP] 108 [/SUP], Yoko Ito[SUP] 108 [/SUP], Satoru Hashimoto[SUP] 109 [/SUP], Masaki Yamasaki[SUP] 109 [/SUP], Yu Kasamatsu[SUP] 110 [/SUP], Yuko Komase[SUP] 111 [/SUP], Naoya Hida[SUP] 111 [/SUP], Takahiro Tsuburai[SUP] 111 [/SUP], Baku Oyama[SUP] 111 [/SUP], Minoru Takada[SUP] 112 [/SUP], Hidenori Kanda[SUP] 112 [/SUP], Yuichiro Kitagawa[SUP] 113 [/SUP], Tetsuya Fukuta[SUP] 113 [/SUP], Takahito Miyake[SUP] 113 [/SUP], Shozo Yoshida[SUP] 113 [/SUP], Shinji Ogura[SUP] 113 [/SUP], Shinji Abe[SUP] 114 [/SUP], Yuta Kono[SUP] 114 [/SUP], Yuki Togashi[SUP] 114 [/SUP], Hiroyuki Takoi[SUP] 114 [/SUP], Ryota Kikuchi[SUP] 114 [/SUP], Shinichi Ogawa[SUP] 115 [/SUP], Tomouki Ogata[SUP] 115 [/SUP], Shoichiro Ishihara[SUP] 115 [/SUP], Arihiko Kanehiro[SUP] 116 117 [/SUP], Shinji Ozaki[SUP] 116 [/SUP], Yasuko Fuchimoto[SUP] 116 [/SUP], Sae Wada[SUP] 116 [/SUP], Nobukazu Fujimoto[SUP] 116 [/SUP], Kei Nishiyama[SUP] 118 [/SUP], Mariko Terashima[SUP] 119 [/SUP], Satoru Beppu[SUP] 119 [/SUP], Kosuke Yoshida[SUP] 119 [/SUP], Osamu Narumoto[SUP] 120 [/SUP], Hideaki Nagai[SUP] 120 [/SUP], Nobuharu Ooshima[SUP] 120 [/SUP], Mitsuru Motegi[SUP] 121 [/SUP], Akira Umeda[SUP] 122 [/SUP], Kazuya Miyagawa[SUP] 123 [/SUP], Hisato Shimada[SUP] 124 [/SUP], Mayu Endo[SUP] 125 [/SUP], Yoshiyuki Ohira[SUP] 122 [/SUP], Masafumi Watanabe[SUP] 126 [/SUP], Sumito Inoue[SUP] 126 [/SUP], Akira Igarashi[SUP] 126 [/SUP], Masamichi Sato[SUP] 126 [/SUP], Hironori Sagara[SUP] 127 [/SUP], Akihiko Tanaka[SUP] 127 [/SUP], Shin Ohta[SUP] 127 [/SUP], Tomoyuki Kimura[SUP] 127 [/SUP], Yoko Shibata[SUP] 128 [/SUP], Yoshinori Tanino[SUP] 128 [/SUP], Takefumi Nikaido[SUP] 128 [/SUP], Hiroyuki Minemura[SUP] 128 [/SUP], Yuki Sato[SUP] 128 [/SUP], Yuichiro Yamada[SUP] 129 [/SUP], Takuya Hashino[SUP] 129 [/SUP], Masato Shinoki[SUP] 129 [/SUP], Hajime Iwagoe[SUP] 130 [/SUP], Hiroshi Takahashi[SUP] 131 [/SUP], Kazuhiko Fujii[SUP] 131 [/SUP], Hiroto Kishi[SUP] 131 [/SUP], Masayuki Kanai[SUP] 132 [/SUP], Tomonori Imamura[SUP] 132 [/SUP], Tatsuya Yamashita[SUP] 132 [/SUP], Masakiyo Yatomi[SUP] 133 [/SUP], Toshitaka Maeno[SUP] 133 [/SUP], Shinichi Hayashi[SUP] 134 [/SUP], Mai Takahashi[SUP] 134 [/SUP], Mizuki Kuramochi[SUP] 134 [/SUP], Isamu Kamimaki[SUP] 134 [/SUP], Yoshiteru Tominaga[SUP] 134 [/SUP], Tomoo Ishii[SUP] 135 [/SUP], Mitsuyoshi Utsugi[SUP] 136 [/SUP], Akihiro Ono[SUP] 136 [/SUP], Toru Tanaka[SUP] 137 [/SUP], Takeru Kashiwada[SUP] 137 [/SUP], Kazue Fujita[SUP] 137 [/SUP], Yoshinobu Saito[SUP] 137 [/SUP], Masahiro Seike[SUP] 137 [/SUP], Hiroko Watanabe[SUP] 138 [/SUP], Hiroto Matsuse[SUP] 139 [/SUP], Norio Kodaka[SUP] 139 [/SUP], Chihiro Nakano[SUP] 139 [/SUP], Takeshi Oshio[SUP] 139 [/SUP], Takatomo Hirouchi[SUP] 139 [/SUP], Shohei Makino[SUP] 140 [/SUP], Moritoki Egi[SUP] 140 [/SUP], Yosuke Omae[SUP] 141 [/SUP], Yasuhito Nannya[SUP] 8 [/SUP], Takafumi Ueno[SUP] 142 [/SUP], Tomomi Takano[SUP] 143 [/SUP], Kazuhiko Katayama[SUP] 144 [/SUP], Masumi Ai[SUP] 145 [/SUP], Atsushi Kumanogoh[SUP] 3 6 13 146 [/SUP], Toshiro Sato[SUP] 147 [/SUP], Naoki Hasegawa[SUP] 4 [/SUP], Katsushi Tokunaga[SUP] 141 [/SUP], Makoto Ishii[SUP] 7 [/SUP], Ryuji Koike[SUP] 148 [/SUP], Yuko Kitagawa[SUP] 149 [/SUP], Akinori Kimura[SUP] 150 [/SUP], Seiya Imoto[SUP] 9 [/SUP], Satoru Miyano[SUP] #[/SUP][SUP] 5 [/SUP], Seishi Ogawa[SUP] #[/SUP][SUP] 8 151 152 [/SUP], Takanori Kanai[SUP] #[/SUP][SUP] 24 153 [/SUP], Koichi Fukunaga[SUP] #[/SUP][SUP] 7 [/SUP], Yukinori Okada[SUP] #[/SUP][SUP] 154 155 156 157 158 159 [/SUP]
Affiliations
- PMID: 35995775
- DOI: 10.1038/s41467-022-32276-2
Abstract
Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.