tetano
Editor, Senior Moderator
Nat Commun
. 2021 Jul 27;12(1):4543.
doi: 10.1038/s41467-021-24482-1.
The trans-omics landscape of COVID-19
Peng Wu[SUP] #[/SUP][SUP] 1 2 [/SUP], Dongsheng Chen[SUP] #[/SUP][SUP] 3 [/SUP], Wencheng Ding[SUP] #[/SUP][SUP] 1 2 [/SUP], Ping Wu[SUP] #[/SUP][SUP] 1 2 [/SUP], Hongyan Hou[SUP] #[/SUP][SUP] 4 [/SUP], Yong Bai[SUP] #[/SUP][SUP] 3 [/SUP], Yuwen Zhou[SUP] #[/SUP][SUP] 3 5 [/SUP], Kezhen Li[SUP] #[/SUP][SUP] 1 2 [/SUP], Shunian Xiang[SUP] 3 [/SUP], Panhong Liu[SUP] 3 [/SUP], Jia Ju[SUP] 3 5 [/SUP], Ensong Guo[SUP] 1 2 [/SUP], Jia Liu[SUP] 1 2 [/SUP], Bin Yang[SUP] 1 2 [/SUP], Junpeng Fan[SUP] 1 [/SUP], Liang He[SUP] 1 [/SUP], Ziyong Sun[SUP] 4 [/SUP], Ling Feng[SUP] 6 [/SUP], Jian Wang[SUP] 7 [/SUP], Tangchun Wu[SUP] 8 [/SUP], Hao Wang[SUP] 8 [/SUP], Jin Cheng[SUP] 9 [/SUP], Hui Xing[SUP] 10 [/SUP], Yifan Meng[SUP] 11 [/SUP], Yongsheng Li[SUP] 12 [/SUP], Yuanliang Zhang[SUP] 3 [/SUP], Hongbo Luo[SUP] 3 13 [/SUP], Gang Xie[SUP] 3 5 [/SUP], Xianmei Lan[SUP] 3 [/SUP], Ye Tao[SUP] 3 [/SUP], Jiafeng Li[SUP] 3 5 [/SUP], Hao Yuan[SUP] 3 5 [/SUP], Kang Huang[SUP] 3 [/SUP], Wan Sun[SUP] 3 [/SUP], Xiaobo Qian[SUP] 3 5 [/SUP], Zhichao Li[SUP] 3 5 [/SUP], Mingxi Huang[SUP] 3 5 [/SUP], Peiwen Ding[SUP] 3 5 [/SUP], Haoyu Wang[SUP] 3 5 [/SUP], Jiaying Qiu[SUP] 3 5 [/SUP], Feiyue Wang[SUP] 3 5 [/SUP], Shiyou Wang[SUP] 3 5 [/SUP], Jiacheng Zhu[SUP] 3 5 [/SUP], Xiangning Ding[SUP] 3 5 [/SUP], Chaochao Chai[SUP] 3 5 [/SUP], Langchao Liang[SUP] 3 5 [/SUP], Xiaoling Wang[SUP] 3 5 [/SUP], Lihua Luo[SUP] 3 5 [/SUP], Yuzhe Sun[SUP] 3 [/SUP], Ying Yang[SUP] 3 [/SUP], Zhenkun Zhuang[SUP] 3 14 [/SUP], Tao Li[SUP] 3 [/SUP], Lei Tian[SUP] 3 [/SUP], Shaoqiao Zhang[SUP] 15 [/SUP], Linnan Zhu[SUP] 3 [/SUP], Ashley Chang[SUP] 3 [/SUP], Lei Chen[SUP] 16 [/SUP], Yiquan Wu[SUP] 17 [/SUP], Xiaoyan Ma[SUP] 18 [/SUP], Fang Chen[SUP] 3 [/SUP], Yan Ren[SUP] 3 [/SUP], Xun Xu[SUP] 3 19 [/SUP], Siqi Liu[SUP] 3 [/SUP], Jian Wang[SUP] 3 20 [/SUP], Huanming Yang[SUP] 3 20 [/SUP], Lin Wang[SUP] 21 [/SUP], Chaoyang Sun[SUP] 22 23 [/SUP], Ding Ma[SUP] 24 25 [/SUP], Xin Jin[SUP] 26 27 28 [/SUP], Gang Chen[SUP] 29 30 [/SUP]
Affiliations
Abstract
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19.
. 2021 Jul 27;12(1):4543.
doi: 10.1038/s41467-021-24482-1.
The trans-omics landscape of COVID-19
Peng Wu[SUP] #[/SUP][SUP] 1 2 [/SUP], Dongsheng Chen[SUP] #[/SUP][SUP] 3 [/SUP], Wencheng Ding[SUP] #[/SUP][SUP] 1 2 [/SUP], Ping Wu[SUP] #[/SUP][SUP] 1 2 [/SUP], Hongyan Hou[SUP] #[/SUP][SUP] 4 [/SUP], Yong Bai[SUP] #[/SUP][SUP] 3 [/SUP], Yuwen Zhou[SUP] #[/SUP][SUP] 3 5 [/SUP], Kezhen Li[SUP] #[/SUP][SUP] 1 2 [/SUP], Shunian Xiang[SUP] 3 [/SUP], Panhong Liu[SUP] 3 [/SUP], Jia Ju[SUP] 3 5 [/SUP], Ensong Guo[SUP] 1 2 [/SUP], Jia Liu[SUP] 1 2 [/SUP], Bin Yang[SUP] 1 2 [/SUP], Junpeng Fan[SUP] 1 [/SUP], Liang He[SUP] 1 [/SUP], Ziyong Sun[SUP] 4 [/SUP], Ling Feng[SUP] 6 [/SUP], Jian Wang[SUP] 7 [/SUP], Tangchun Wu[SUP] 8 [/SUP], Hao Wang[SUP] 8 [/SUP], Jin Cheng[SUP] 9 [/SUP], Hui Xing[SUP] 10 [/SUP], Yifan Meng[SUP] 11 [/SUP], Yongsheng Li[SUP] 12 [/SUP], Yuanliang Zhang[SUP] 3 [/SUP], Hongbo Luo[SUP] 3 13 [/SUP], Gang Xie[SUP] 3 5 [/SUP], Xianmei Lan[SUP] 3 [/SUP], Ye Tao[SUP] 3 [/SUP], Jiafeng Li[SUP] 3 5 [/SUP], Hao Yuan[SUP] 3 5 [/SUP], Kang Huang[SUP] 3 [/SUP], Wan Sun[SUP] 3 [/SUP], Xiaobo Qian[SUP] 3 5 [/SUP], Zhichao Li[SUP] 3 5 [/SUP], Mingxi Huang[SUP] 3 5 [/SUP], Peiwen Ding[SUP] 3 5 [/SUP], Haoyu Wang[SUP] 3 5 [/SUP], Jiaying Qiu[SUP] 3 5 [/SUP], Feiyue Wang[SUP] 3 5 [/SUP], Shiyou Wang[SUP] 3 5 [/SUP], Jiacheng Zhu[SUP] 3 5 [/SUP], Xiangning Ding[SUP] 3 5 [/SUP], Chaochao Chai[SUP] 3 5 [/SUP], Langchao Liang[SUP] 3 5 [/SUP], Xiaoling Wang[SUP] 3 5 [/SUP], Lihua Luo[SUP] 3 5 [/SUP], Yuzhe Sun[SUP] 3 [/SUP], Ying Yang[SUP] 3 [/SUP], Zhenkun Zhuang[SUP] 3 14 [/SUP], Tao Li[SUP] 3 [/SUP], Lei Tian[SUP] 3 [/SUP], Shaoqiao Zhang[SUP] 15 [/SUP], Linnan Zhu[SUP] 3 [/SUP], Ashley Chang[SUP] 3 [/SUP], Lei Chen[SUP] 16 [/SUP], Yiquan Wu[SUP] 17 [/SUP], Xiaoyan Ma[SUP] 18 [/SUP], Fang Chen[SUP] 3 [/SUP], Yan Ren[SUP] 3 [/SUP], Xun Xu[SUP] 3 19 [/SUP], Siqi Liu[SUP] 3 [/SUP], Jian Wang[SUP] 3 20 [/SUP], Huanming Yang[SUP] 3 20 [/SUP], Lin Wang[SUP] 21 [/SUP], Chaoyang Sun[SUP] 22 23 [/SUP], Ding Ma[SUP] 24 25 [/SUP], Xin Jin[SUP] 26 27 28 [/SUP], Gang Chen[SUP] 29 30 [/SUP]
Affiliations
- PMID: 34315889
- DOI: 10.1038/s41467-021-24482-1
Abstract
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19.