tetano
Editor, Senior Moderator
Nat Commun
. 2025 Jul 1;16(1):5717.
doi: 10.1038/s41467-025-60784-4. Systematic review of post-COVID condition in Nordic population-based registry studies
Jan Peter William Himmels[SUP] 1 [/SUP], Karin Magnusson[SUP] 2 3 [/SUP], Kjetil Gundro Brurberg[SUP] 2 4 [/SUP]
Affiliations
The long-term effects of COVID-19, known as post-COVID condition (PCC), are still not fully understood. This systematic review synthesizes findings from Nordic registry studies to highlight long-term outcomes after COVID-19 infection. Twenty-two studies, primarily reflecting the pre-omicron and early vaccination phases, reveal increased primary care use for respiratory issues and fatigue in the sub-acute and chronic phases, with PCC incidence estimated below 2% in the general population. Most individuals returned to work within three months post-infection, and the risk of new neurological or mental disorders did not exceed that in patients with other infections. The review demonstrates the value of high-quality Nordic health registries in capturing reliable, population-wide data, though generalizability may be limited to similar healthcare systems. Findings suggest the need for targeted follow-up in patients with severe COVID-19, particularly those requiring intensive care, to manage potential new-onset diseases and guide resource allocation in the pandemic's endemic phase.
. 2025 Jul 1;16(1):5717.
doi: 10.1038/s41467-025-60784-4. Systematic review of post-COVID condition in Nordic population-based registry studies
Jan Peter William Himmels[SUP] 1 [/SUP], Karin Magnusson[SUP] 2 3 [/SUP], Kjetil Gundro Brurberg[SUP] 2 4 [/SUP]
Affiliations
- PMID: 40592834
- PMCID: PMC12219526
- DOI: 10.1038/s41467-025-60784-4
The long-term effects of COVID-19, known as post-COVID condition (PCC), are still not fully understood. This systematic review synthesizes findings from Nordic registry studies to highlight long-term outcomes after COVID-19 infection. Twenty-two studies, primarily reflecting the pre-omicron and early vaccination phases, reveal increased primary care use for respiratory issues and fatigue in the sub-acute and chronic phases, with PCC incidence estimated below 2% in the general population. Most individuals returned to work within three months post-infection, and the risk of new neurological or mental disorders did not exceed that in patients with other infections. The review demonstrates the value of high-quality Nordic health registries in capturing reliable, population-wide data, though generalizability may be limited to similar healthcare systems. Findings suggest the need for targeted follow-up in patients with severe COVID-19, particularly those requiring intensive care, to manage potential new-onset diseases and guide resource allocation in the pandemic's endemic phase.