tetano
Editor, Senior Moderator
Nat Commun. 2020 Jan 16;11(1):315. doi: 10.1038/s41467-019-14230-x. [h=1]Oil-in-water emulsion adjuvants for pediatric influenza vaccines: a systematic review and meta-analysis.[/h]
Lin YJ[SUP]1,[/SUP][SUP]2[/SUP], Wen CN[SUP]1,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Lin YY[SUP]1,[/SUP][SUP]5[/SUP], Hsieh WC[SUP]1[/SUP], Chang CC[SUP]1[/SUP], Chen YH[SUP]1[/SUP], Hsu CH[SUP]1,[/SUP][SUP]5[/SUP], Shih YJ[SUP]1,[/SUP][SUP]2[/SUP], Chen CH[SUP]2[/SUP], Fang CT[SUP]6,[/SUP][SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Standard inactivated influenza vaccines are poorly immunogenic in immunologically naive healthy young children, who are particularly vulnerable to complications from influenza. For them, there is an unmet need for better influenza vaccines. Oil-in-water emulsion-adjuvanted influenza vaccines are promising candidates, but clinical trials yielded inconsistent results. Here, we meta-analyze randomized controlled trials with efficacy data (3 trials, n = 15,310) and immunogenicity data (17 trials, n = 9062). Compared with non-adjuvanted counterparts, adjuvanted influenza vaccines provide a significantly better protection (weighted estimate for risk ratio of RT-PCR-confirmed influenza: 0.26) and are significantly more immunogenic (weighted estimates for seroprotection rate ratio: 4.6 to 7.9) in healthy immunologically naive young children. Nevertheless, in immunologically non-naive children, adjuvanted and non-adjuvanted vaccines provide similar protection and are similarly immunogenic. These results indicate that oil-in-water emulsion adjuvant improves the efficacy of inactivated influenza vaccines in healthy young children at the first-time seasonal influenza vaccination.
PMID: 31949137 DOI: 10.1038/s41467-019-14230-x
Lin YJ[SUP]1,[/SUP][SUP]2[/SUP], Wen CN[SUP]1,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Lin YY[SUP]1,[/SUP][SUP]5[/SUP], Hsieh WC[SUP]1[/SUP], Chang CC[SUP]1[/SUP], Chen YH[SUP]1[/SUP], Hsu CH[SUP]1,[/SUP][SUP]5[/SUP], Shih YJ[SUP]1,[/SUP][SUP]2[/SUP], Chen CH[SUP]2[/SUP], Fang CT[SUP]6,[/SUP][SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Standard inactivated influenza vaccines are poorly immunogenic in immunologically naive healthy young children, who are particularly vulnerable to complications from influenza. For them, there is an unmet need for better influenza vaccines. Oil-in-water emulsion-adjuvanted influenza vaccines are promising candidates, but clinical trials yielded inconsistent results. Here, we meta-analyze randomized controlled trials with efficacy data (3 trials, n = 15,310) and immunogenicity data (17 trials, n = 9062). Compared with non-adjuvanted counterparts, adjuvanted influenza vaccines provide a significantly better protection (weighted estimate for risk ratio of RT-PCR-confirmed influenza: 0.26) and are significantly more immunogenic (weighted estimates for seroprotection rate ratio: 4.6 to 7.9) in healthy immunologically naive young children. Nevertheless, in immunologically non-naive children, adjuvanted and non-adjuvanted vaccines provide similar protection and are similarly immunogenic. These results indicate that oil-in-water emulsion adjuvant improves the efficacy of inactivated influenza vaccines in healthy young children at the first-time seasonal influenza vaccination.
PMID: 31949137 DOI: 10.1038/s41467-019-14230-x