tetano
Editor, Senior Moderator
Nat Commun
. 2020 Dec 9;11(1):6317.
doi: 10.1038/s41467-020-19741-6.
Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission
Hannah Peckham[SUP] 1 2 [/SUP], Nina M de Gruijter[SUP] 1 2 [/SUP], Charles Raine[SUP] 2 [/SUP], Anna Radziszewska[SUP] 1 2 [/SUP], Coziana Ciurtin[SUP] 1 2 [/SUP], Lucy R Wedderburn[SUP] 1 3 4 [/SUP], Elizabeth C Rosser[SUP] 1 2 [/SUP], Kate Webb[SUP] 5 6 [/SUP], Claire T Deakin[SUP] 7 8 9 [/SUP]
Affiliations
Abstract
Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes. Here, we present a meta-analysis of 3,111,714 reported global cases to demonstrate that, whilst there is no difference in the proportion of males and females with confirmed COVID-19, male patients have almost three times the odds of requiring intensive treatment unit (ITU) admission (OR = 2.84; 95% CI = 2.06, 3.92) and higher odds of death (OR = 1.39; 95% CI = 1.31, 1.47) compared to females. With few exceptions, the sex bias observed in COVID-19 is a worldwide phenomenon. An appreciation of how sex is influencing COVID-19 outcomes will have important implications for clinical management and mitigation strategies for this disease.
. 2020 Dec 9;11(1):6317.
doi: 10.1038/s41467-020-19741-6.
Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission
Hannah Peckham[SUP] 1 2 [/SUP], Nina M de Gruijter[SUP] 1 2 [/SUP], Charles Raine[SUP] 2 [/SUP], Anna Radziszewska[SUP] 1 2 [/SUP], Coziana Ciurtin[SUP] 1 2 [/SUP], Lucy R Wedderburn[SUP] 1 3 4 [/SUP], Elizabeth C Rosser[SUP] 1 2 [/SUP], Kate Webb[SUP] 5 6 [/SUP], Claire T Deakin[SUP] 7 8 9 [/SUP]
Affiliations
- PMID: 33298944
- DOI: 10.1038/s41467-020-19741-6
Abstract
Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes. Here, we present a meta-analysis of 3,111,714 reported global cases to demonstrate that, whilst there is no difference in the proportion of males and females with confirmed COVID-19, male patients have almost three times the odds of requiring intensive treatment unit (ITU) admission (OR = 2.84; 95% CI = 2.06, 3.92) and higher odds of death (OR = 1.39; 95% CI = 1.31, 1.47) compared to females. With few exceptions, the sex bias observed in COVID-19 is a worldwide phenomenon. An appreciation of how sex is influencing COVID-19 outcomes will have important implications for clinical management and mitigation strategies for this disease.