tetano
Editor, Senior Moderator
Nat Commun
. 2024 Mar 19;15(1):2444.
doi: 10.1038/s41467-024-46692-z. Long-term effects of Omicron BA.2 breakthrough infection on immunity-metabolism balance: a 6-month prospective study
Yanhua Li[SUP] #[/SUP][SUP] 1 [/SUP], Shijie Qin[SUP] #[/SUP][SUP] 1 2 [/SUP], Lei Dong[SUP] #[/SUP][SUP] 3 [/SUP], Shitong Qiao[SUP] #[/SUP][SUP] 1 4 [/SUP], Xiao Wang[SUP] #[/SUP][SUP] 5 [/SUP], Dongshan Yu[SUP] 6 [/SUP], Pengyue Gao[SUP] 1 [/SUP], Yali Hou[SUP] 7 [/SUP], Shouzhen Quan[SUP] 3 [/SUP], Ying Li[SUP] 3 [/SUP], Fengyan Fan[SUP] 3 [/SUP], Xin Zhao[SUP] 8 9 10 [/SUP], Yueyun Ma[SUP] 11 [/SUP], George Fu Gao[SUP] 12 13 14 [/SUP]
Affiliations
There have been reports of long coronavirus disease (long COVID) and breakthrough infections (BTIs); however, the mechanisms and pathological features of long COVID after Omicron BTIs remain unclear. Assessing long-term effects of COVID-19 and immune recovery after Omicron BTIs is crucial for understanding the disease and managing new-generation vaccines. Here, we followed up mild BA.2 BTI convalescents for six-month with routine blood tests, proteomic analysis and single-cell RNA sequencing (scRNA-seq). We found that major organs exhibited ephemeral dysfunction and recovered to normal in approximately six-month after BA.2 BTI. We also observed durable and potent levels of neutralizing antibodies against major circulating sub-variants, indicating that hybrid humoral immunity stays active. However, platelets may take longer to recover based on proteomic analyses, which also shows coagulation disorder and an imbalance between anti-pathogen immunity and metabolism six-month after BA.2 BTI. The immunity-metabolism imbalance was then confirmed with retrospective analysis of abnormal levels of hormones, low blood glucose level and coagulation profile. The long-term malfunctional coagulation and imbalance in the material metabolism and immunity may contribute to the development of long COVID and act as useful indicator for assessing recovery and the long-term impacts after Omicron sub-variant BTIs.
. 2024 Mar 19;15(1):2444.
doi: 10.1038/s41467-024-46692-z. Long-term effects of Omicron BA.2 breakthrough infection on immunity-metabolism balance: a 6-month prospective study
Yanhua Li[SUP] #[/SUP][SUP] 1 [/SUP], Shijie Qin[SUP] #[/SUP][SUP] 1 2 [/SUP], Lei Dong[SUP] #[/SUP][SUP] 3 [/SUP], Shitong Qiao[SUP] #[/SUP][SUP] 1 4 [/SUP], Xiao Wang[SUP] #[/SUP][SUP] 5 [/SUP], Dongshan Yu[SUP] 6 [/SUP], Pengyue Gao[SUP] 1 [/SUP], Yali Hou[SUP] 7 [/SUP], Shouzhen Quan[SUP] 3 [/SUP], Ying Li[SUP] 3 [/SUP], Fengyan Fan[SUP] 3 [/SUP], Xin Zhao[SUP] 8 9 10 [/SUP], Yueyun Ma[SUP] 11 [/SUP], George Fu Gao[SUP] 12 13 14 [/SUP]
Affiliations
- PMID: 38503738
- DOI: 10.1038/s41467-024-46692-z
There have been reports of long coronavirus disease (long COVID) and breakthrough infections (BTIs); however, the mechanisms and pathological features of long COVID after Omicron BTIs remain unclear. Assessing long-term effects of COVID-19 and immune recovery after Omicron BTIs is crucial for understanding the disease and managing new-generation vaccines. Here, we followed up mild BA.2 BTI convalescents for six-month with routine blood tests, proteomic analysis and single-cell RNA sequencing (scRNA-seq). We found that major organs exhibited ephemeral dysfunction and recovered to normal in approximately six-month after BA.2 BTI. We also observed durable and potent levels of neutralizing antibodies against major circulating sub-variants, indicating that hybrid humoral immunity stays active. However, platelets may take longer to recover based on proteomic analyses, which also shows coagulation disorder and an imbalance between anti-pathogen immunity and metabolism six-month after BA.2 BTI. The immunity-metabolism imbalance was then confirmed with retrospective analysis of abnormal levels of hormones, low blood glucose level and coagulation profile. The long-term malfunctional coagulation and imbalance in the material metabolism and immunity may contribute to the development of long COVID and act as useful indicator for assessing recovery and the long-term impacts after Omicron sub-variant BTIs.