tetano
Editor, Senior Moderator
Nat Commun
. 2022 Sep 29;13(1):5706.
doi: 10.1038/s41467-022-33233-9.
Increased household transmission and immune escape of the SARS-CoV-2 Omicron compared to Delta variants
Neda Jalali[SUP] 1 [/SUP], Hilde K Brustad[SUP] 2 [/SUP], Arnoldo Frigessi[SUP] 2 3 [/SUP], Emily A MacDonald[SUP] 1 [/SUP], Hinta Meijerink[SUP] 1 [/SUP], Siri L Feruglio[SUP] 1 [/SUP], Karin M Nygård[SUP] 1 [/SUP], Gunnar Rø[SUP] 1 [/SUP], Elisabeth H Madslien[SUP] 1 [/SUP], Birgitte Freiesleben de Blasio[SUP] 4 5 [/SUP]
Affiliations
Abstract
Understanding the epidemic growth of the novel SARS-CoV-2 Omicron variant is critical for public health. We compared the ten-day secondary attack rate (SAR) of the Omicron and Delta variants in households using Norwegian contact tracing data, December 2021 - January 2022. Omicron SAR was higher than Delta, with a relative risk (RR) of 1.41 (95% CI 1.27-1.56). We observed increased susceptibility to Omicron infection in household contacts compared to Delta, independent of contacts' vaccination status. Among three-dose vaccinated contacts, the mean SAR was lower for both variants. We found increased Omicron transmissibility from primary cases to contacts in all vaccination groups, except 1-dose vaccinated, compared to Delta. Omicron SAR of three-dose vaccinated primary cases was high, 46% vs 11 % for Delta. In conclusion, three-dose vaccinated primary cases with Omicron infection can efficiently spread in households, while three-dose vaccinated contacts have a lower risk of being infected by Delta and Omicron.
. 2022 Sep 29;13(1):5706.
doi: 10.1038/s41467-022-33233-9.
Increased household transmission and immune escape of the SARS-CoV-2 Omicron compared to Delta variants
Neda Jalali[SUP] 1 [/SUP], Hilde K Brustad[SUP] 2 [/SUP], Arnoldo Frigessi[SUP] 2 3 [/SUP], Emily A MacDonald[SUP] 1 [/SUP], Hinta Meijerink[SUP] 1 [/SUP], Siri L Feruglio[SUP] 1 [/SUP], Karin M Nygård[SUP] 1 [/SUP], Gunnar Rø[SUP] 1 [/SUP], Elisabeth H Madslien[SUP] 1 [/SUP], Birgitte Freiesleben de Blasio[SUP] 4 5 [/SUP]
Affiliations
- PMID: 36175424
- PMCID: PMC9520116
- DOI: 10.1038/s41467-022-33233-9
Abstract
Understanding the epidemic growth of the novel SARS-CoV-2 Omicron variant is critical for public health. We compared the ten-day secondary attack rate (SAR) of the Omicron and Delta variants in households using Norwegian contact tracing data, December 2021 - January 2022. Omicron SAR was higher than Delta, with a relative risk (RR) of 1.41 (95% CI 1.27-1.56). We observed increased susceptibility to Omicron infection in household contacts compared to Delta, independent of contacts' vaccination status. Among three-dose vaccinated contacts, the mean SAR was lower for both variants. We found increased Omicron transmissibility from primary cases to contacts in all vaccination groups, except 1-dose vaccinated, compared to Delta. Omicron SAR of three-dose vaccinated primary cases was high, 46% vs 11 % for Delta. In conclusion, three-dose vaccinated primary cases with Omicron infection can efficiently spread in households, while three-dose vaccinated contacts have a lower risk of being infected by Delta and Omicron.