tetano
Editor, Senior Moderator
Nat Commun
. 2022 Apr 1;13(1):1726.
doi: 10.1038/s41467-022-29404-3.
High failure rate of ChAdOx1-nCoV19 immunization against asymptomatic infection in healthcare workers during a Delta variant surge
Rajat Ujjainiya[SUP] #[/SUP][SUP] 1 2 [/SUP], Akansha Tyagi[SUP] #[/SUP][SUP] 3 [/SUP], Viren Sardana[SUP] #[/SUP][SUP] 1 2 [/SUP], Salwa Naushin[SUP] 1 2 [/SUP], Nitin Bhatheja[SUP] 1 [/SUP], Kartik Kumar[SUP] 1 [/SUP], Joydeb Barman[SUP] 1 [/SUP], Satyartha Prakash[SUP] 1 [/SUP], Rintu Kutum[SUP] 1 4 [/SUP], Akash Kumar Bhaskar[SUP] 1 2 [/SUP], Prateek Singh[SUP] 1 2 [/SUP], Kumardeep Chaudhary[SUP] 1 2 [/SUP], Menka Loomba[SUP] 3 [/SUP], Yukti Khanna[SUP] 3 [/SUP], Chestha Walecha[SUP] 3 [/SUP], Rizwan Ahmed[SUP] 3 [/SUP], Ashutosh Yadav[SUP] 5 [/SUP], Archana Bajaj[SUP] 6 [/SUP], Gaurav Malik[SUP] 6 [/SUP], Sahar Qureshi[SUP] 7 [/SUP], Swati Waghdhare[SUP] 5 [/SUP], Samreen Siddiqui[SUP] 5 [/SUP], Kamal Krishan Trehan[SUP] 6 [/SUP], Manju Mani[SUP] 7 [/SUP], Rajiv Dang[SUP] 8 [/SUP], Poonam Das[SUP] 9 [/SUP], Pankaj Dougall[SUP] 10 [/SUP], Monica Mahajan[SUP] 11 [/SUP], Sudipta Sonar[SUP] 12 [/SUP], Kamini Jakhar[SUP] 12 [/SUP], Reema Kumar[SUP] 12 [/SUP], Mahima Tiwari[SUP] 12 [/SUP], Shailendra Mani[SUP] 12 [/SUP], Sankar Bhattacharyya[SUP] 12 [/SUP], Sandeep Budhiraja[SUP] 13 [/SUP], Anurag Agrawal[SUP] 1 2 [/SUP], Debasis Dash[SUP] 14 15 [/SUP], Sujeet Jha[SUP] 16 [/SUP], Shantanu Sengupta[SUP] 17 18 [/SUP]
Affiliations
Abstract
Immunization is expected to confer protection against infection and severe disease for vaccines while reducing risks to unimmunized populations by inhibiting transmission. Here, based on serial serological studies of an observational cohort of healthcare workers, we show that during a Severe Acute Respiratory Syndrome -Coronavirus 2 Delta-variant outbreak in Delhi, 25.3% (95% Confidence Interval 16.9-35.2) of previously uninfected, ChAdOx1-nCoV19 double vaccinated, healthcare workers were infected within less than two months, based on serology. Induction of anti-spike response was similar between groups with breakthrough infection (541 U/ml, Inter Quartile Range 374) and without (342 U/ml, Inter Quartile Range 497), as was the induction of neutralization activity to wildtype. This was not vaccine failure since vaccine effectiveness estimate based on infection rates in an unvaccinated cohort were about 70% and most infections were asymptomatic. We find that while ChAdOx1-nCoV19 vaccination remains effective in preventing severe infections, it is unlikely to be completely able to block transmission and provide herd immunity.
. 2022 Apr 1;13(1):1726.
doi: 10.1038/s41467-022-29404-3.
High failure rate of ChAdOx1-nCoV19 immunization against asymptomatic infection in healthcare workers during a Delta variant surge
Rajat Ujjainiya[SUP] #[/SUP][SUP] 1 2 [/SUP], Akansha Tyagi[SUP] #[/SUP][SUP] 3 [/SUP], Viren Sardana[SUP] #[/SUP][SUP] 1 2 [/SUP], Salwa Naushin[SUP] 1 2 [/SUP], Nitin Bhatheja[SUP] 1 [/SUP], Kartik Kumar[SUP] 1 [/SUP], Joydeb Barman[SUP] 1 [/SUP], Satyartha Prakash[SUP] 1 [/SUP], Rintu Kutum[SUP] 1 4 [/SUP], Akash Kumar Bhaskar[SUP] 1 2 [/SUP], Prateek Singh[SUP] 1 2 [/SUP], Kumardeep Chaudhary[SUP] 1 2 [/SUP], Menka Loomba[SUP] 3 [/SUP], Yukti Khanna[SUP] 3 [/SUP], Chestha Walecha[SUP] 3 [/SUP], Rizwan Ahmed[SUP] 3 [/SUP], Ashutosh Yadav[SUP] 5 [/SUP], Archana Bajaj[SUP] 6 [/SUP], Gaurav Malik[SUP] 6 [/SUP], Sahar Qureshi[SUP] 7 [/SUP], Swati Waghdhare[SUP] 5 [/SUP], Samreen Siddiqui[SUP] 5 [/SUP], Kamal Krishan Trehan[SUP] 6 [/SUP], Manju Mani[SUP] 7 [/SUP], Rajiv Dang[SUP] 8 [/SUP], Poonam Das[SUP] 9 [/SUP], Pankaj Dougall[SUP] 10 [/SUP], Monica Mahajan[SUP] 11 [/SUP], Sudipta Sonar[SUP] 12 [/SUP], Kamini Jakhar[SUP] 12 [/SUP], Reema Kumar[SUP] 12 [/SUP], Mahima Tiwari[SUP] 12 [/SUP], Shailendra Mani[SUP] 12 [/SUP], Sankar Bhattacharyya[SUP] 12 [/SUP], Sandeep Budhiraja[SUP] 13 [/SUP], Anurag Agrawal[SUP] 1 2 [/SUP], Debasis Dash[SUP] 14 15 [/SUP], Sujeet Jha[SUP] 16 [/SUP], Shantanu Sengupta[SUP] 17 18 [/SUP]
Affiliations
- PMID: 35365648
- DOI: 10.1038/s41467-022-29404-3
Abstract
Immunization is expected to confer protection against infection and severe disease for vaccines while reducing risks to unimmunized populations by inhibiting transmission. Here, based on serial serological studies of an observational cohort of healthcare workers, we show that during a Severe Acute Respiratory Syndrome -Coronavirus 2 Delta-variant outbreak in Delhi, 25.3% (95% Confidence Interval 16.9-35.2) of previously uninfected, ChAdOx1-nCoV19 double vaccinated, healthcare workers were infected within less than two months, based on serology. Induction of anti-spike response was similar between groups with breakthrough infection (541 U/ml, Inter Quartile Range 374) and without (342 U/ml, Inter Quartile Range 497), as was the induction of neutralization activity to wildtype. This was not vaccine failure since vaccine effectiveness estimate based on infection rates in an unvaccinated cohort were about 70% and most infections were asymptomatic. We find that while ChAdOx1-nCoV19 vaccination remains effective in preventing severe infections, it is unlikely to be completely able to block transmission and provide herd immunity.
