tetano
Editor, Senior Moderator
Nat Commun
. 2024 Oct 9;15(1):8739.
doi: 10.1038/s41467-024-52890-6. Genome-wide association studies of COVID-19 vaccine seroconversion and breakthrough outcomes in UK Biobank
Marta Alcalde-Herraiz[SUP] 1 [/SUP], Martí Català[SUP] 1 [/SUP], Albert Prats-Uribe[SUP] 1 [/SUP], Roger Paredes[SUP] 2 3 [/SUP], JunQing Xie[SUP] #[/SUP][SUP] 1 [/SUP], Daniel Prieto-Alhambra[SUP] #[/SUP][SUP] 4 5 [/SUP]
Affiliations
Understanding the genetic basis of COVID-19 vaccine seroconversion is crucial to study the role of genetics on vaccine effectiveness. In our study, we used UK Biobank data to find the genetic determinants of COVID-19 vaccine-induced seropositivity and breakthrough infections. We conducted four genome-wide association studies among vaccinated participants for COVID-19 vaccine seroconversion and breakthrough susceptibility and severity. Our findings confirmed a link between the HLA region and seroconversion after the first and second doses. Additionally, we identified 10 genomic regions associated with breakthrough infection (SLC6A20, ST6GAL1, MUC16, FUT6, MXI1, MUC4, HMGN2P18-KRTCAP2, NFKBIZ and APOC1), and one with breakthrough severity (APOE). No significant evidence of genetic colocalisation was found between those traits. Our study highlights the roles of individual genetic make-up in the varied antibody responses to COVID-19 vaccines and provides insights into the potential mechanisms behind breakthrough infections occurred even after the vaccination.
. 2024 Oct 9;15(1):8739.
doi: 10.1038/s41467-024-52890-6. Genome-wide association studies of COVID-19 vaccine seroconversion and breakthrough outcomes in UK Biobank
Marta Alcalde-Herraiz[SUP] 1 [/SUP], Martí Català[SUP] 1 [/SUP], Albert Prats-Uribe[SUP] 1 [/SUP], Roger Paredes[SUP] 2 3 [/SUP], JunQing Xie[SUP] #[/SUP][SUP] 1 [/SUP], Daniel Prieto-Alhambra[SUP] #[/SUP][SUP] 4 5 [/SUP]
Affiliations
- PMID: 39384777
- DOI: 10.1038/s41467-024-52890-6
Understanding the genetic basis of COVID-19 vaccine seroconversion is crucial to study the role of genetics on vaccine effectiveness. In our study, we used UK Biobank data to find the genetic determinants of COVID-19 vaccine-induced seropositivity and breakthrough infections. We conducted four genome-wide association studies among vaccinated participants for COVID-19 vaccine seroconversion and breakthrough susceptibility and severity. Our findings confirmed a link between the HLA region and seroconversion after the first and second doses. Additionally, we identified 10 genomic regions associated with breakthrough infection (SLC6A20, ST6GAL1, MUC16, FUT6, MXI1, MUC4, HMGN2P18-KRTCAP2, NFKBIZ and APOC1), and one with breakthrough severity (APOE). No significant evidence of genetic colocalisation was found between those traits. Our study highlights the roles of individual genetic make-up in the varied antibody responses to COVID-19 vaccines and provides insights into the potential mechanisms behind breakthrough infections occurred even after the vaccination.