tetano
Editor, Senior Moderator
Nat Commun
. 2021 Aug 18;12(1):5026.
doi: 10.1038/s41467-021-25120-6.
Etiological and epidemiological features of acute respiratory infections in China
Zhong-Jie Li[SUP] #[/SUP][SUP] 1 [/SUP], Hai-Yang Zhang[SUP] #[/SUP][SUP] 2 [/SUP], Li-Li Ren[SUP] #[/SUP][SUP] 3 [/SUP], Qing-Bin Lu[SUP] #[/SUP][SUP] 4 [/SUP], Xiang Ren[SUP] 1 [/SUP], Cui-Hong Zhang[SUP] 1 [/SUP], Yi-Fei Wang[SUP] 1 [/SUP], Sheng-Hong Lin[SUP] 1 [/SUP], Xiao-Ai Zhang[SUP] 2 [/SUP], Jun Li[SUP] 5 [/SUP], Shi-Wen Zhao[SUP] 6 [/SUP], Zhi-Gang Yi[SUP] 7 [/SUP], Xiao Chen[SUP] 8 [/SUP], Zuo-Sen Yang[SUP] 9 [/SUP], Lei Meng[SUP] 10 [/SUP], Xin-Hua Wang[SUP] 10 [/SUP], Ying-Le Liu[SUP] 11 [/SUP], Xin Wang[SUP] 12 [/SUP], Ai-Li Cui[SUP] 13 [/SUP], Sheng-Jie Lai[SUP] 1 14 15 [/SUP], Tao Jiang[SUP] 2 [/SUP], Yang Yuan[SUP] 2 [/SUP], Lu-Sha Shi[SUP] 1 [/SUP], Meng-Yang Liu[SUP] 2 [/SUP], Yu-Liang Zhu[SUP] 1 [/SUP], An-Ran Zhang[SUP] 2 [/SUP], Zhi-Jie Zhang[SUP] 16 [/SUP], Yang Yang[SUP] 17 [/SUP], Michael P Ward[SUP] 18 [/SUP], Lu-Zhao Feng[SUP] 1 [/SUP], Huai-Qi Jing[SUP] 12 [/SUP], Liu-Yu Huang[SUP] 19 [/SUP], Wen-Bo Xu[SUP] 13 [/SUP], Yu Chen[SUP] 8 [/SUP], Jian-Guo Wu[SUP] 11 [/SUP], Zheng-Hong Yuan[SUP] 20 [/SUP], Meng-Feng Li[SUP] 5 [/SUP], Yu Wang[SUP] 21 [/SUP], Li-Ping Wang[SUP] 22 [/SUP], Li-Qun Fang[SUP] 23 [/SUP], Wei Liu[SUP] 24 [/SUP], Simon I Hay[SUP] 25 26 [/SUP], George F Gao[SUP] 21 [/SUP], Wei-Zhong Yang[SUP] 21 [/SUP], Chinese Centers for Disease Control and Prevention (CDC) Etiology of Respiratory Infection Surveillance Study Team
Collaborators, Affiliations
Abstract
Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features of the 231,107 eligible patients enrolled in this analysis. Children <5 years old and school-age children have the highest viral positivity rate (46.9%) and bacterial positivity rate (30.9%). Influenza virus, respiratory syncytial virus and human rhinovirus are the three leading viral pathogens with proportions of 28.5%, 16.8% and 16.7%, and Streptococcus pneumoniae, Mycoplasma pneumoniae and Klebsiella pneumoniae are the three leading bacterial pathogens (29.9%, 18.6% and 15.8%). Negative interactions between viruses and positive interactions between viral and bacterial pathogens are common. A Join-Point analysis reveals the age-specific positivity rate and how this varied for individual pathogens. These data indicate that differential priorities for diagnosis, prevention and control should be highlighted in terms of acute respiratory tract infection patients' demography, geographic locations and season of illness in China.
. 2021 Aug 18;12(1):5026.
doi: 10.1038/s41467-021-25120-6.
Etiological and epidemiological features of acute respiratory infections in China
Zhong-Jie Li[SUP] #[/SUP][SUP] 1 [/SUP], Hai-Yang Zhang[SUP] #[/SUP][SUP] 2 [/SUP], Li-Li Ren[SUP] #[/SUP][SUP] 3 [/SUP], Qing-Bin Lu[SUP] #[/SUP][SUP] 4 [/SUP], Xiang Ren[SUP] 1 [/SUP], Cui-Hong Zhang[SUP] 1 [/SUP], Yi-Fei Wang[SUP] 1 [/SUP], Sheng-Hong Lin[SUP] 1 [/SUP], Xiao-Ai Zhang[SUP] 2 [/SUP], Jun Li[SUP] 5 [/SUP], Shi-Wen Zhao[SUP] 6 [/SUP], Zhi-Gang Yi[SUP] 7 [/SUP], Xiao Chen[SUP] 8 [/SUP], Zuo-Sen Yang[SUP] 9 [/SUP], Lei Meng[SUP] 10 [/SUP], Xin-Hua Wang[SUP] 10 [/SUP], Ying-Le Liu[SUP] 11 [/SUP], Xin Wang[SUP] 12 [/SUP], Ai-Li Cui[SUP] 13 [/SUP], Sheng-Jie Lai[SUP] 1 14 15 [/SUP], Tao Jiang[SUP] 2 [/SUP], Yang Yuan[SUP] 2 [/SUP], Lu-Sha Shi[SUP] 1 [/SUP], Meng-Yang Liu[SUP] 2 [/SUP], Yu-Liang Zhu[SUP] 1 [/SUP], An-Ran Zhang[SUP] 2 [/SUP], Zhi-Jie Zhang[SUP] 16 [/SUP], Yang Yang[SUP] 17 [/SUP], Michael P Ward[SUP] 18 [/SUP], Lu-Zhao Feng[SUP] 1 [/SUP], Huai-Qi Jing[SUP] 12 [/SUP], Liu-Yu Huang[SUP] 19 [/SUP], Wen-Bo Xu[SUP] 13 [/SUP], Yu Chen[SUP] 8 [/SUP], Jian-Guo Wu[SUP] 11 [/SUP], Zheng-Hong Yuan[SUP] 20 [/SUP], Meng-Feng Li[SUP] 5 [/SUP], Yu Wang[SUP] 21 [/SUP], Li-Ping Wang[SUP] 22 [/SUP], Li-Qun Fang[SUP] 23 [/SUP], Wei Liu[SUP] 24 [/SUP], Simon I Hay[SUP] 25 26 [/SUP], George F Gao[SUP] 21 [/SUP], Wei-Zhong Yang[SUP] 21 [/SUP], Chinese Centers for Disease Control and Prevention (CDC) Etiology of Respiratory Infection Surveillance Study Team
Collaborators, Affiliations
- PMID: 34408158
- DOI: 10.1038/s41467-021-25120-6
Abstract
Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features of the 231,107 eligible patients enrolled in this analysis. Children <5 years old and school-age children have the highest viral positivity rate (46.9%) and bacterial positivity rate (30.9%). Influenza virus, respiratory syncytial virus and human rhinovirus are the three leading viral pathogens with proportions of 28.5%, 16.8% and 16.7%, and Streptococcus pneumoniae, Mycoplasma pneumoniae and Klebsiella pneumoniae are the three leading bacterial pathogens (29.9%, 18.6% and 15.8%). Negative interactions between viruses and positive interactions between viral and bacterial pathogens are common. A Join-Point analysis reveals the age-specific positivity rate and how this varied for individual pathogens. These data indicate that differential priorities for diagnosis, prevention and control should be highlighted in terms of acute respiratory tract infection patients' demography, geographic locations and season of illness in China.