tetano
Editor, Senior Moderator
Nat Commun
. 2024 Aug 29;15(1):7466.
doi: 10.1038/s41467-024-51893-7. Early biological markers of post-acute sequelae of SARS-CoV-2 infection
Scott Lu[SUP] #[/SUP][SUP] 1 2 [/SUP], Michael J Peluso[SUP] #[/SUP][SUP] 3 [/SUP], David V Glidden[SUP] 2 [/SUP], Michelle C Davidson[SUP] 4 [/SUP], Kara Lugtu[SUP] 1 [/SUP], Jesus Pineda-Ramirez[SUP] 1 [/SUP], Michel Tassetto[SUP] 5 [/SUP], Miguel Garcia-Knight[SUP] 5 6 [/SUP], Amethyst Zhang[SUP] 5 [/SUP], Sarah A Goldberg[SUP] 2 [/SUP], Jessica Y Chen[SUP] 2 [/SUP], Maya Fortes-Cobby[SUP] 1 [/SUP], Sara Park[SUP] 1 [/SUP], Ana Martinez[SUP] 1 [/SUP], Matthew So[SUP] 1 [/SUP], Aidan Donovan[SUP] 3 [/SUP], Badri Viswanathan[SUP] 2 [/SUP], Rebecca Hoh[SUP] 3 [/SUP], Kevin Donohue[SUP] 4 [/SUP], David R McIlwain[SUP] 7 [/SUP], Brice Gaudiliere[SUP] 7 [/SUP], Khamal Anglin[SUP] 1 [/SUP], Brandon C Yee[SUP] 8 [/SUP], Ahmed Chenna[SUP] 8 [/SUP], John W Winslow[SUP] 8 [/SUP], Christos J Petropoulos[SUP] 8 [/SUP], Steven G Deeks[SUP] 3 [/SUP], Melissa Briggs-Hagen[SUP] 9 [/SUP], Raul Andino[SUP] 5 [/SUP], Claire M Midgley[SUP] 9 [/SUP], Jeffrey N Martin[SUP] 2 [/SUP], Sharon Saydah[SUP] 9 [/SUP], J Daniel Kelly[SUP] 10 11 12 13 [/SUP]
Affiliations
To understand the roles of acute-phase viral dynamics and host immune responses in post-acute sequelae of SARS-CoV-2 infection (PASC), we enrolled 136 participants within 5 days of their first positive SARS-CoV-2 real-time PCR test. Participants self-collected up to 21 nasal specimens within the first 28 days post-symptom onset; interviewer-administered questionnaires and blood samples were collected at enrollment, days 9, 14, 21, 28, and month 4 and 8 post-symptom onset. Defining PASC as the presence of any COVID-associated symptom at their 4-month visit, we compared viral markers (quantity and duration of nasal viral RNA load, infectious viral load, and plasma N-antigen level) and host immune markers (IL-6, IL-10, TNF-α, IFN-α, IFN-γ, MCP, IP-10, and Spike IgG) over the acute period. Compared to those who fully recovered, those reporting PASC demonstrated significantly higher maximum levels of SARS-CoV-2 RNA and N-antigen, burden of RNA and infectious viral shedding, and lower Spike-specific IgG levels within 9 days post-illness onset. No significant differences were identified among a panel of host immune markers. Our results suggest early viral dynamics and the associated host immune responses play a role in the pathogenesis of PASC, highlighting the importance of understanding early biological markers in the natural history of PASC.
. 2024 Aug 29;15(1):7466.
doi: 10.1038/s41467-024-51893-7. Early biological markers of post-acute sequelae of SARS-CoV-2 infection
Scott Lu[SUP] #[/SUP][SUP] 1 2 [/SUP], Michael J Peluso[SUP] #[/SUP][SUP] 3 [/SUP], David V Glidden[SUP] 2 [/SUP], Michelle C Davidson[SUP] 4 [/SUP], Kara Lugtu[SUP] 1 [/SUP], Jesus Pineda-Ramirez[SUP] 1 [/SUP], Michel Tassetto[SUP] 5 [/SUP], Miguel Garcia-Knight[SUP] 5 6 [/SUP], Amethyst Zhang[SUP] 5 [/SUP], Sarah A Goldberg[SUP] 2 [/SUP], Jessica Y Chen[SUP] 2 [/SUP], Maya Fortes-Cobby[SUP] 1 [/SUP], Sara Park[SUP] 1 [/SUP], Ana Martinez[SUP] 1 [/SUP], Matthew So[SUP] 1 [/SUP], Aidan Donovan[SUP] 3 [/SUP], Badri Viswanathan[SUP] 2 [/SUP], Rebecca Hoh[SUP] 3 [/SUP], Kevin Donohue[SUP] 4 [/SUP], David R McIlwain[SUP] 7 [/SUP], Brice Gaudiliere[SUP] 7 [/SUP], Khamal Anglin[SUP] 1 [/SUP], Brandon C Yee[SUP] 8 [/SUP], Ahmed Chenna[SUP] 8 [/SUP], John W Winslow[SUP] 8 [/SUP], Christos J Petropoulos[SUP] 8 [/SUP], Steven G Deeks[SUP] 3 [/SUP], Melissa Briggs-Hagen[SUP] 9 [/SUP], Raul Andino[SUP] 5 [/SUP], Claire M Midgley[SUP] 9 [/SUP], Jeffrey N Martin[SUP] 2 [/SUP], Sharon Saydah[SUP] 9 [/SUP], J Daniel Kelly[SUP] 10 11 12 13 [/SUP]
Affiliations
- PMID: 39198441
- PMCID: PMC11358427
- DOI: 10.1038/s41467-024-51893-7
To understand the roles of acute-phase viral dynamics and host immune responses in post-acute sequelae of SARS-CoV-2 infection (PASC), we enrolled 136 participants within 5 days of their first positive SARS-CoV-2 real-time PCR test. Participants self-collected up to 21 nasal specimens within the first 28 days post-symptom onset; interviewer-administered questionnaires and blood samples were collected at enrollment, days 9, 14, 21, 28, and month 4 and 8 post-symptom onset. Defining PASC as the presence of any COVID-associated symptom at their 4-month visit, we compared viral markers (quantity and duration of nasal viral RNA load, infectious viral load, and plasma N-antigen level) and host immune markers (IL-6, IL-10, TNF-α, IFN-α, IFN-γ, MCP, IP-10, and Spike IgG) over the acute period. Compared to those who fully recovered, those reporting PASC demonstrated significantly higher maximum levels of SARS-CoV-2 RNA and N-antigen, burden of RNA and infectious viral shedding, and lower Spike-specific IgG levels within 9 days post-illness onset. No significant differences were identified among a panel of host immune markers. Our results suggest early viral dynamics and the associated host immune responses play a role in the pathogenesis of PASC, highlighting the importance of understanding early biological markers in the natural history of PASC.