tetano
Editor, Senior Moderator
Nat Commun
. 2022 Jul 27;13(1):4350.
doi: 10.1038/s41467-022-31929-6.
Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines
Li Wang[SUP] #[/SUP][SUP] 1 [/SUP], Markus H Kainulainen[SUP] #[/SUP][SUP] 1 [/SUP], Nannan Jiang[SUP] #[/SUP][SUP] 1 [/SUP], Han Di[SUP] #[/SUP][SUP] 1 [/SUP], Gaston Bonenfant[SUP] #[/SUP][SUP] 1 [/SUP], Lisa Mills[SUP] 1 [/SUP], Michael Currier[SUP] 1 [/SUP], Punya Shrivastava-Ranjan[SUP] 1 [/SUP], Brenda M Calderon[SUP] 1 [/SUP], Mili Sheth[SUP] 1 [/SUP], Brian R Mann[SUP] 1 [/SUP], Jaber Hossain[SUP] 1 [/SUP], Xudong Lin[SUP] 1 [/SUP], Sandra Lester[SUP] 1 [/SUP], Elizabeth A Pusch[SUP] 1 [/SUP], Joyce Jones[SUP] 1 [/SUP], Dan Cui[SUP] 1 [/SUP], Payel Chatterjee[SUP] 1 [/SUP], M Harley Jenks[SUP] 1 [/SUP], Esther K Morantz[SUP] 1 [/SUP], Gloria P Larson[SUP] 1 [/SUP], Masato Hatta[SUP] 1 [/SUP], Jennifer L Harcourt[SUP] 1 [/SUP], Azaibi Tamin[SUP] 1 [/SUP], Yan Li[SUP] 1 [/SUP], Ying Tao[SUP] 1 [/SUP], Kun Zhao[SUP] 1 [/SUP], Kristine Lacek[SUP] 1 [/SUP], Ashley Burroughs[SUP] 1 [/SUP], Wei Wang[SUP] 1 [/SUP], Malania Wilson[SUP] 1 [/SUP], Terianne Wong[SUP] 1 [/SUP], So Hee Park[SUP] 1 [/SUP], Suxiang Tong[SUP] 1 [/SUP], John R Barnes[SUP] 1 [/SUP], Mark W Tenforde[SUP] 1 [/SUP], Wesley H Self[SUP] 2 [/SUP], Nathan I Shapiro[SUP] 3 [/SUP], Matthew C Exline[SUP] 4 [/SUP], D Clark Files[SUP] 5 [/SUP], Kevin W Gibbs[SUP] 5 [/SUP], David N Hager[SUP] 6 [/SUP], Manish Patel[SUP] 1 [/SUP], Alison L Halpin[SUP] 1 [/SUP], Laura K McMullan[SUP] 1 [/SUP], Justin S Lee[SUP] 1 [/SUP], Hongjie Xia[SUP] 7 [/SUP], Xuping Xie[SUP] 7 [/SUP], Pei-Yong Shi[SUP] 7 [/SUP], C Todd Davis[SUP] 1 [/SUP], Christina F Spiropoulou[SUP] 1 [/SUP], Natalie J Thornburg[SUP] 1 [/SUP], M Steven Oberste[SUP] 1 [/SUP], Vivien G Dugan[SUP] 1 [/SUP], SSEV Bioinformatics Working Group; David E Wentworth[SUP] 8 [/SUP], Bin Zhou[SUP] 9 [/SUP]
Collaborators, Affiliations
Abstract
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence of new variant lineages that have exacerbated the COVID-19 pandemic. Some of those variants were designated as variants of concern/interest (VOC/VOI) by national or international authorities based on many factors including their potential impact on vaccine-mediated protection from disease. To ascertain and rank the risk of VOCs and VOIs, we analyze the ability of 14 variants (614G, Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, Mu, and Omicron) to escape from mRNA vaccine-induced antibodies. The variants show differential reductions in neutralization and replication by post-vaccination sera. Although the Omicron variant (BA.1, BA.1.1, and BA.2) shows the most escape from neutralization, sera collected after a third dose of vaccine (booster sera) retain moderate neutralizing activity against that variant. Therefore, vaccination remains an effective strategy during the COVID-19 pandemic.
. 2022 Jul 27;13(1):4350.
doi: 10.1038/s41467-022-31929-6.
Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines
Li Wang[SUP] #[/SUP][SUP] 1 [/SUP], Markus H Kainulainen[SUP] #[/SUP][SUP] 1 [/SUP], Nannan Jiang[SUP] #[/SUP][SUP] 1 [/SUP], Han Di[SUP] #[/SUP][SUP] 1 [/SUP], Gaston Bonenfant[SUP] #[/SUP][SUP] 1 [/SUP], Lisa Mills[SUP] 1 [/SUP], Michael Currier[SUP] 1 [/SUP], Punya Shrivastava-Ranjan[SUP] 1 [/SUP], Brenda M Calderon[SUP] 1 [/SUP], Mili Sheth[SUP] 1 [/SUP], Brian R Mann[SUP] 1 [/SUP], Jaber Hossain[SUP] 1 [/SUP], Xudong Lin[SUP] 1 [/SUP], Sandra Lester[SUP] 1 [/SUP], Elizabeth A Pusch[SUP] 1 [/SUP], Joyce Jones[SUP] 1 [/SUP], Dan Cui[SUP] 1 [/SUP], Payel Chatterjee[SUP] 1 [/SUP], M Harley Jenks[SUP] 1 [/SUP], Esther K Morantz[SUP] 1 [/SUP], Gloria P Larson[SUP] 1 [/SUP], Masato Hatta[SUP] 1 [/SUP], Jennifer L Harcourt[SUP] 1 [/SUP], Azaibi Tamin[SUP] 1 [/SUP], Yan Li[SUP] 1 [/SUP], Ying Tao[SUP] 1 [/SUP], Kun Zhao[SUP] 1 [/SUP], Kristine Lacek[SUP] 1 [/SUP], Ashley Burroughs[SUP] 1 [/SUP], Wei Wang[SUP] 1 [/SUP], Malania Wilson[SUP] 1 [/SUP], Terianne Wong[SUP] 1 [/SUP], So Hee Park[SUP] 1 [/SUP], Suxiang Tong[SUP] 1 [/SUP], John R Barnes[SUP] 1 [/SUP], Mark W Tenforde[SUP] 1 [/SUP], Wesley H Self[SUP] 2 [/SUP], Nathan I Shapiro[SUP] 3 [/SUP], Matthew C Exline[SUP] 4 [/SUP], D Clark Files[SUP] 5 [/SUP], Kevin W Gibbs[SUP] 5 [/SUP], David N Hager[SUP] 6 [/SUP], Manish Patel[SUP] 1 [/SUP], Alison L Halpin[SUP] 1 [/SUP], Laura K McMullan[SUP] 1 [/SUP], Justin S Lee[SUP] 1 [/SUP], Hongjie Xia[SUP] 7 [/SUP], Xuping Xie[SUP] 7 [/SUP], Pei-Yong Shi[SUP] 7 [/SUP], C Todd Davis[SUP] 1 [/SUP], Christina F Spiropoulou[SUP] 1 [/SUP], Natalie J Thornburg[SUP] 1 [/SUP], M Steven Oberste[SUP] 1 [/SUP], Vivien G Dugan[SUP] 1 [/SUP], SSEV Bioinformatics Working Group; David E Wentworth[SUP] 8 [/SUP], Bin Zhou[SUP] 9 [/SUP]
Collaborators, Affiliations
- PMID: 35896523
- DOI: 10.1038/s41467-022-31929-6
Abstract
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence of new variant lineages that have exacerbated the COVID-19 pandemic. Some of those variants were designated as variants of concern/interest (VOC/VOI) by national or international authorities based on many factors including their potential impact on vaccine-mediated protection from disease. To ascertain and rank the risk of VOCs and VOIs, we analyze the ability of 14 variants (614G, Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, Mu, and Omicron) to escape from mRNA vaccine-induced antibodies. The variants show differential reductions in neutralization and replication by post-vaccination sera. Although the Omicron variant (BA.1, BA.1.1, and BA.2) shows the most escape from neutralization, sera collected after a third dose of vaccine (booster sera) retain moderate neutralizing activity against that variant. Therefore, vaccination remains an effective strategy during the COVID-19 pandemic.