tetano
Editor, Senior Moderator
Nat Commun
. 2024 Feb 19;15(1):1492.
doi: 10.1038/s41467-024-45468-9. Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study
John S Kim[SUP] 1 2 [/SUP], Yifei Sun[SUP] 3 [/SUP], Pallavi Balte[SUP] 2 [/SUP], Mary Cushman[SUP] 4 5 [/SUP], Rebekah Boyle[SUP] 5 [/SUP], Russell P Tracy[SUP] 5 [/SUP], Linda M Styer[SUP] 6 [/SUP], Taison D Bell[SUP] 1 [/SUP], Michaela R Anderson[SUP] 7 [/SUP], Norrina B Allen[SUP] 8 [/SUP], Pamela J Schreiner[SUP] 9 [/SUP], Russell P Bowler[SUP] 10 [/SUP], David A Schwartz[SUP] 11 [/SUP], Joyce S Lee[SUP] 11 [/SUP], Vanessa Xanthakis[SUP] 12 13 [/SUP], Margaret F Doyle[SUP] 5 [/SUP], Elizabeth A Regan[SUP] 14 [/SUP], Barry J Make[SUP] 10 [/SUP], Alka M Kanaya[SUP] 15 [/SUP], Sally E Wenzel[SUP] 16 [/SUP], Josef Coresh[SUP] 17 18 [/SUP], Carmen R Isasi[SUP] 19 [/SUP], Laura M Raffield[SUP] 20 [/SUP], Mitchell S V Elkind[SUP] 21 22 [/SUP], Virginia J Howard[SUP] 23 [/SUP], Victor E Ortega[SUP] 24 [/SUP], Prescott Woodruff[SUP] 25 [/SUP], Shelley A Cole[SUP] 26 [/SUP], Joel M Henderson[SUP] 27 [/SUP], Nicholas J Mantis[SUP] 6 28 [/SUP], Monica M Parker[SUP] 6 [/SUP], Ryan T Demmer[SUP] #[/SUP][SUP] 29 30 31 [/SUP], Elizabeth C Oelsner[SUP] #[/SUP][SUP] 32 [/SUP]
Affiliations
This study investigates correlates of anti-S1 antibody response following COVID-19 vaccination in a U.S. population-based meta-cohort of adults participating in longstanding NIH-funded cohort studies. Anti-S1 antibodies were measured from dried blood spots collected between February 2021-August 2022 using Luminex-based microsphere immunoassays. Of 6245 participants, mean age was 73 years (range, 21-100), 58% were female, and 76% were non-Hispanic White. Nearly 52% of participants received the BNT162b2 vaccine and 48% received the mRNA-1273 vaccine. Lower anti-S1 antibody levels are associated with age of 65 years or older, male sex, higher body mass index, smoking, diabetes, COPD and receipt of BNT16b2 vaccine (vs mRNA-1273). Participants with a prior infection, particularly those with a history of hospitalized illness, have higher anti-S1 antibody levels. These results suggest that adults with certain socio-demographic and clinical characteristics may have less robust antibody responses to COVID-19 vaccination and could be prioritized for more frequent re-vaccination.
. 2024 Feb 19;15(1):1492.
doi: 10.1038/s41467-024-45468-9. Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study
John S Kim[SUP] 1 2 [/SUP], Yifei Sun[SUP] 3 [/SUP], Pallavi Balte[SUP] 2 [/SUP], Mary Cushman[SUP] 4 5 [/SUP], Rebekah Boyle[SUP] 5 [/SUP], Russell P Tracy[SUP] 5 [/SUP], Linda M Styer[SUP] 6 [/SUP], Taison D Bell[SUP] 1 [/SUP], Michaela R Anderson[SUP] 7 [/SUP], Norrina B Allen[SUP] 8 [/SUP], Pamela J Schreiner[SUP] 9 [/SUP], Russell P Bowler[SUP] 10 [/SUP], David A Schwartz[SUP] 11 [/SUP], Joyce S Lee[SUP] 11 [/SUP], Vanessa Xanthakis[SUP] 12 13 [/SUP], Margaret F Doyle[SUP] 5 [/SUP], Elizabeth A Regan[SUP] 14 [/SUP], Barry J Make[SUP] 10 [/SUP], Alka M Kanaya[SUP] 15 [/SUP], Sally E Wenzel[SUP] 16 [/SUP], Josef Coresh[SUP] 17 18 [/SUP], Carmen R Isasi[SUP] 19 [/SUP], Laura M Raffield[SUP] 20 [/SUP], Mitchell S V Elkind[SUP] 21 22 [/SUP], Virginia J Howard[SUP] 23 [/SUP], Victor E Ortega[SUP] 24 [/SUP], Prescott Woodruff[SUP] 25 [/SUP], Shelley A Cole[SUP] 26 [/SUP], Joel M Henderson[SUP] 27 [/SUP], Nicholas J Mantis[SUP] 6 28 [/SUP], Monica M Parker[SUP] 6 [/SUP], Ryan T Demmer[SUP] #[/SUP][SUP] 29 30 31 [/SUP], Elizabeth C Oelsner[SUP] #[/SUP][SUP] 32 [/SUP]
Affiliations
- PMID: 38374032
- PMCID: PMC10876680
- DOI: 10.1038/s41467-024-45468-9
This study investigates correlates of anti-S1 antibody response following COVID-19 vaccination in a U.S. population-based meta-cohort of adults participating in longstanding NIH-funded cohort studies. Anti-S1 antibodies were measured from dried blood spots collected between February 2021-August 2022 using Luminex-based microsphere immunoassays. Of 6245 participants, mean age was 73 years (range, 21-100), 58% were female, and 76% were non-Hispanic White. Nearly 52% of participants received the BNT162b2 vaccine and 48% received the mRNA-1273 vaccine. Lower anti-S1 antibody levels are associated with age of 65 years or older, male sex, higher body mass index, smoking, diabetes, COPD and receipt of BNT16b2 vaccine (vs mRNA-1273). Participants with a prior infection, particularly those with a history of hospitalized illness, have higher anti-S1 antibody levels. These results suggest that adults with certain socio-demographic and clinical characteristics may have less robust antibody responses to COVID-19 vaccination and could be prioritized for more frequent re-vaccination.