tetano
Editor, Senior Moderator
Nat Commun
. 2022 May 10;13(1):2314.
doi: 10.1038/s41467-022-29614-9.
Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic
Livia V Patrono[SUP] #[/SUP][SUP] 1 2 [/SUP], Bram Vrancken[SUP] #[/SUP][SUP] 3 [/SUP], Matthias Budt[SUP] #[/SUP][SUP] 4 [/SUP], Ariane Düx[SUP] 1 2 [/SUP], Sebastian Lequime[SUP] 5 [/SUP], Sengül Boral[SUP] 6 [/SUP], M Thomas P Gilbert[SUP] 7 8 [/SUP], Jan F Gogarten[SUP] 1 2 [/SUP], Luisa Hoffmann[SUP] 4 [/SUP], David Horst[SUP] 6 [/SUP], Kevin Merkel[SUP] 1 2 [/SUP], David Morens[SUP] 9 [/SUP], Baptiste Prepoint[SUP] 2 10 [/SUP], Jasmin Schlotterbeck[SUP] 2 [/SUP], Verena J Schuenemann[SUP] 11 [/SUP], Marc A Suchard[SUP] 12 13 14 [/SUP], Jeffery K Taubenberger[SUP] 15 [/SUP], Luisa Tenkhoff[SUP] 4 [/SUP], Christian Urban[SUP] 11 [/SUP], Navena Widulin[SUP] 16 [/SUP], Eduard Winter[SUP] 17 [/SUP], Michael Worobey[SUP] 18 [/SUP], Thomas Schnalke[SUP] 16 [/SUP], Thorsten Wolff[SUP] 4 [/SUP], Philippe Lemey[SUP] 3 [/SUP], Sébastien Calvignac-Spencer[SUP] 19 20 [/SUP]
Affiliations
Abstract
The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.
. 2022 May 10;13(1):2314.
doi: 10.1038/s41467-022-29614-9.
Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic
Livia V Patrono[SUP] #[/SUP][SUP] 1 2 [/SUP], Bram Vrancken[SUP] #[/SUP][SUP] 3 [/SUP], Matthias Budt[SUP] #[/SUP][SUP] 4 [/SUP], Ariane Düx[SUP] 1 2 [/SUP], Sebastian Lequime[SUP] 5 [/SUP], Sengül Boral[SUP] 6 [/SUP], M Thomas P Gilbert[SUP] 7 8 [/SUP], Jan F Gogarten[SUP] 1 2 [/SUP], Luisa Hoffmann[SUP] 4 [/SUP], David Horst[SUP] 6 [/SUP], Kevin Merkel[SUP] 1 2 [/SUP], David Morens[SUP] 9 [/SUP], Baptiste Prepoint[SUP] 2 10 [/SUP], Jasmin Schlotterbeck[SUP] 2 [/SUP], Verena J Schuenemann[SUP] 11 [/SUP], Marc A Suchard[SUP] 12 13 14 [/SUP], Jeffery K Taubenberger[SUP] 15 [/SUP], Luisa Tenkhoff[SUP] 4 [/SUP], Christian Urban[SUP] 11 [/SUP], Navena Widulin[SUP] 16 [/SUP], Eduard Winter[SUP] 17 [/SUP], Michael Worobey[SUP] 18 [/SUP], Thomas Schnalke[SUP] 16 [/SUP], Thorsten Wolff[SUP] 4 [/SUP], Philippe Lemey[SUP] 3 [/SUP], Sébastien Calvignac-Spencer[SUP] 19 20 [/SUP]
Affiliations
- PMID: 35538057
- DOI: 10.1038/s41467-022-29614-9
Abstract
The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.
