tetano
Editor, Senior Moderator
Nat Commun
. 2022 Aug 30;13(1):5104.
doi: 10.1038/s41467-022-32507-6.
A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity
C Kedor[SUP] #[/SUP][SUP] 1 [/SUP], H Freitag[SUP] #[/SUP][SUP] 2 [/SUP], L Meyer-Arndt[SUP] 3 4 5 [/SUP], K Wittke[SUP] 2 [/SUP], L G Hanitsch[SUP] 2 [/SUP], T Zoller[SUP] 6 [/SUP], F Steinbeis[SUP] 6 [/SUP], M Haffke[SUP] 2 [/SUP], G Rudolf[SUP] 2 [/SUP], B Heidecker[SUP] 7 [/SUP], T Bobbert[SUP] 8 [/SUP], J Spranger[SUP] 8 [/SUP], H D Volk[SUP] 2 9 [/SUP], C Skurk[SUP] 7 [/SUP], F Konietschke[SUP] 10 [/SUP], F Paul[SUP] 3 4 5 [/SUP], U Behrends[SUP] 11 12 13 [/SUP], J Bellmann-Strobl[SUP] #[/SUP][SUP] 2 3 4 5 [/SUP], C Scheibenbogen[SUP] #[/SUP][SUP] 2 [/SUP]
Affiliations
Abstract
A subset of patients has long-lasting symptoms after mild to moderate Coronavirus disease 2019 (COVID-19). In a prospective observational cohort study, we analyze clinical and laboratory parameters in 42 post-COVID-19 syndrome patients (29 female/13 male, median age 36.5 years) with persistent moderate to severe fatigue and exertion intolerance six months following COVID-19. Further we evaluate an age- and sex-matched postinfectious non-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome cohort comparatively. Most post-COVID-19 syndrome patients are moderately to severely impaired in daily live. 19 post-COVID-19 syndrome patients fulfill the 2003 Canadian Consensus Criteria for myalgic encephalomyelitis/chronic fatigue syndrome. Disease severity and symptom burden is similar in post-COVID-19 syndrome/myalgic encephalomyelitis/chronic fatigue syndrome and non-COVID-19/myalgic encephalomyelitis/chronic fatigue syndrome patients. Hand grip strength is diminished in most patients compared to normal values in healthy. Association of hand grip strength with hemoglobin, interleukin 8 and C-reactive protein in post-COVID-19 syndrome/non-myalgic encephalomyelitis/chronic fatigue syndrome and with hemoglobin, N-terminal prohormone of brain natriuretic peptide, bilirubin, and ferritin in post-COVID-19 syndrome/myalgic encephalomyelitis/chronic fatigue syndrome may indicate low level inflammation and hypoperfusion as potential pathomechanisms.
. 2022 Aug 30;13(1):5104.
doi: 10.1038/s41467-022-32507-6.
A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity
C Kedor[SUP] #[/SUP][SUP] 1 [/SUP], H Freitag[SUP] #[/SUP][SUP] 2 [/SUP], L Meyer-Arndt[SUP] 3 4 5 [/SUP], K Wittke[SUP] 2 [/SUP], L G Hanitsch[SUP] 2 [/SUP], T Zoller[SUP] 6 [/SUP], F Steinbeis[SUP] 6 [/SUP], M Haffke[SUP] 2 [/SUP], G Rudolf[SUP] 2 [/SUP], B Heidecker[SUP] 7 [/SUP], T Bobbert[SUP] 8 [/SUP], J Spranger[SUP] 8 [/SUP], H D Volk[SUP] 2 9 [/SUP], C Skurk[SUP] 7 [/SUP], F Konietschke[SUP] 10 [/SUP], F Paul[SUP] 3 4 5 [/SUP], U Behrends[SUP] 11 12 13 [/SUP], J Bellmann-Strobl[SUP] #[/SUP][SUP] 2 3 4 5 [/SUP], C Scheibenbogen[SUP] #[/SUP][SUP] 2 [/SUP]
Affiliations
- PMID: 36042189
- DOI: 10.1038/s41467-022-32507-6
Abstract
A subset of patients has long-lasting symptoms after mild to moderate Coronavirus disease 2019 (COVID-19). In a prospective observational cohort study, we analyze clinical and laboratory parameters in 42 post-COVID-19 syndrome patients (29 female/13 male, median age 36.5 years) with persistent moderate to severe fatigue and exertion intolerance six months following COVID-19. Further we evaluate an age- and sex-matched postinfectious non-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome cohort comparatively. Most post-COVID-19 syndrome patients are moderately to severely impaired in daily live. 19 post-COVID-19 syndrome patients fulfill the 2003 Canadian Consensus Criteria for myalgic encephalomyelitis/chronic fatigue syndrome. Disease severity and symptom burden is similar in post-COVID-19 syndrome/myalgic encephalomyelitis/chronic fatigue syndrome and non-COVID-19/myalgic encephalomyelitis/chronic fatigue syndrome patients. Hand grip strength is diminished in most patients compared to normal values in healthy. Association of hand grip strength with hemoglobin, interleukin 8 and C-reactive protein in post-COVID-19 syndrome/non-myalgic encephalomyelitis/chronic fatigue syndrome and with hemoglobin, N-terminal prohormone of brain natriuretic peptide, bilirubin, and ferritin in post-COVID-19 syndrome/myalgic encephalomyelitis/chronic fatigue syndrome may indicate low level inflammation and hypoperfusion as potential pathomechanisms.