tetano
Editor, Senior Moderator
Nat Commun. 2016 Feb 19;7:10680. doi: 10.1038/ncomms10680.
[h=1]Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.[/h] Holm CK[SUP]1,[/SUP][SUP]2[/SUP], Rahbek SH[SUP]1,[/SUP][SUP]2[/SUP], Gad HH[SUP]2,[/SUP][SUP]3[/SUP], Bak RO[SUP]1,[/SUP][SUP]2[/SUP], Jakobsen MR[SUP]1,[/SUP][SUP]2[/SUP], Jiang Z[SUP]4[/SUP], Hansen AL[SUP]1,[/SUP][SUP]2[/SUP], Jensen SK[SUP]1[/SUP], Sun C[SUP]1,[/SUP][SUP]2[/SUP], Thomsen MK[SUP]1,[/SUP][SUP]2[/SUP], Laustsen A[SUP]1,[/SUP][SUP]2[/SUP], Nielsen CG[SUP]1,[/SUP][SUP]2[/SUP], Severinsen K[SUP]5[/SUP], Xiong Y[SUP]1,[/SUP][SUP]6[/SUP], Burdette DL[SUP]7[/SUP], Hornung V[SUP]8[/SUP], Lebbink RJ[SUP]9[/SUP], Duch M[SUP]3,[/SUP][SUP]10[/SUP], Fitzgerald KA[SUP]4[/SUP], Bahrami S[SUP]3,[/SUP][SUP]10[/SUP], Mikkelsen JG[SUP]1,[/SUP][SUP]2[/SUP], Hartmann R[SUP]2,[/SUP][SUP]3[/SUP], Paludan SR[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection with DNA viruses STING is activated downstream of cGAMP synthase (cGAS) to induce type I interferon. Here we identify a STING-dependent, cGAS-independent pathway important for full interferon production and antiviral control of enveloped RNA viruses, including influenza A virus (IAV). Further, IAV interacts with STING through its conserved hemagglutinin fusion peptide (FP). Interestingly, FP antagonizes interferon production induced by membrane fusion or IAV but not by cGAMP or DNA. Similar to the enveloped RNA viruses, membrane fusion stimulates interferon production in a STING-dependent but cGAS-independent manner. Abolishment of this pathway led to reduced interferon production and impaired control of enveloped RNA viruses. Thus, enveloped RNA viruses stimulate a cGAS-independent STING pathway, which is targeted by IAV.
PMID: 26893169 [PubMed - in process]
[h=1]Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.[/h] Holm CK[SUP]1,[/SUP][SUP]2[/SUP], Rahbek SH[SUP]1,[/SUP][SUP]2[/SUP], Gad HH[SUP]2,[/SUP][SUP]3[/SUP], Bak RO[SUP]1,[/SUP][SUP]2[/SUP], Jakobsen MR[SUP]1,[/SUP][SUP]2[/SUP], Jiang Z[SUP]4[/SUP], Hansen AL[SUP]1,[/SUP][SUP]2[/SUP], Jensen SK[SUP]1[/SUP], Sun C[SUP]1,[/SUP][SUP]2[/SUP], Thomsen MK[SUP]1,[/SUP][SUP]2[/SUP], Laustsen A[SUP]1,[/SUP][SUP]2[/SUP], Nielsen CG[SUP]1,[/SUP][SUP]2[/SUP], Severinsen K[SUP]5[/SUP], Xiong Y[SUP]1,[/SUP][SUP]6[/SUP], Burdette DL[SUP]7[/SUP], Hornung V[SUP]8[/SUP], Lebbink RJ[SUP]9[/SUP], Duch M[SUP]3,[/SUP][SUP]10[/SUP], Fitzgerald KA[SUP]4[/SUP], Bahrami S[SUP]3,[/SUP][SUP]10[/SUP], Mikkelsen JG[SUP]1,[/SUP][SUP]2[/SUP], Hartmann R[SUP]2,[/SUP][SUP]3[/SUP], Paludan SR[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection with DNA viruses STING is activated downstream of cGAMP synthase (cGAS) to induce type I interferon. Here we identify a STING-dependent, cGAS-independent pathway important for full interferon production and antiviral control of enveloped RNA viruses, including influenza A virus (IAV). Further, IAV interacts with STING through its conserved hemagglutinin fusion peptide (FP). Interestingly, FP antagonizes interferon production induced by membrane fusion or IAV but not by cGAMP or DNA. Similar to the enveloped RNA viruses, membrane fusion stimulates interferon production in a STING-dependent but cGAS-independent manner. Abolishment of this pathway led to reduced interferon production and impaired control of enveloped RNA viruses. Thus, enveloped RNA viruses stimulate a cGAS-independent STING pathway, which is targeted by IAV.
PMID: 26893169 [PubMed - in process]