tetano
Editor, Senior Moderator
Nat Aging
. 2022 Jun;2(6):536-547.
doi: 10.1038/s43587-022-00224-w. Epub 2022 May 30. Robust SARS-CoV-2-specific and heterologous immune responses in vaccine-naïve residents of long-term care facilities who survive natural infection
Gokhan Tut[SUP] 1 [/SUP], Tara Lancaster[SUP] 2 [/SUP], Megan S Butler[SUP] 2 [/SUP], Panagiota Sylla[SUP] 2 [/SUP], Eliska Spalkova[SUP] 2 [/SUP], David Bone[SUP] 2 [/SUP], Nayandeep Kaur[SUP] 2 [/SUP], Christopher Bentley[SUP] 2 [/SUP], Umayr Amin[SUP] 2 [/SUP], Azar T Jadir[SUP] 2 [/SUP], Samuel Hulme[SUP] 2 [/SUP], Morenike Ayodel[SUP] 2 [/SUP], Alexander C Dowell[SUP] 2 [/SUP], Hayden Pearce[SUP] 2 [/SUP], Jianmin Zuo[SUP] 2 [/SUP], Sandra Margielewska-Davies[SUP] 2 [/SUP], Kriti Verma[SUP] 2 [/SUP], Samantha Nicol[SUP] 2 [/SUP], Jusnara Begum[SUP] 2 [/SUP], Elizabeth Jinks[SUP] 2 [/SUP], Elif Tut[SUP] 2 [/SUP], Rachel Bruton[SUP] 2 [/SUP], Maria Krutikov[SUP] 3 [/SUP], Madhumita Shrotri[SUP] 3 [/SUP], Rebecca Giddings[SUP] 3 [/SUP], Borscha Azmi[SUP] 3 [/SUP], Chris Fuller[SUP] 3 [/SUP], Aidan Irwin-Singer[SUP] 4 [/SUP], Andrew Hayward[SUP] 5 [/SUP], Andrew Copas[SUP] 6 [/SUP], Laura Shallcross[SUP] 3 [/SUP], Paul Moss[SUP] 7 [/SUP]
Affiliations
We studied humoral and cellular immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 152 long-term care facility staff and 124 residents over a prospective 4-month period shortly after the first wave of infection in England. We show that residents of long-term care facilities developed high and stable levels of antibodies against spike protein and receptor-binding domain. Nucleocapsid-specific responses were also elevated but waned over time. Antibodies showed stable and equivalent levels of functional inhibition against spike-angiotensin-converting enzyme 2 binding in all age groups with comparable activity against viral variants of concern. SARS-CoV-2 seropositive donors showed high levels of antibodies to other beta-coronaviruses but serostatus did not impact humoral immunity to influenza or other respiratory syncytial viruses. SARS-CoV-2-specific cellular responses were similar across all ages but virus-specific populations showed elevated levels of activation in older donors. Thus, survivors of SARS-CoV-2 infection show a robust and stable immunity against the virus that does not negatively impact responses to other seasonal viruses.
. 2022 Jun;2(6):536-547.
doi: 10.1038/s43587-022-00224-w. Epub 2022 May 30. Robust SARS-CoV-2-specific and heterologous immune responses in vaccine-naïve residents of long-term care facilities who survive natural infection
Gokhan Tut[SUP] 1 [/SUP], Tara Lancaster[SUP] 2 [/SUP], Megan S Butler[SUP] 2 [/SUP], Panagiota Sylla[SUP] 2 [/SUP], Eliska Spalkova[SUP] 2 [/SUP], David Bone[SUP] 2 [/SUP], Nayandeep Kaur[SUP] 2 [/SUP], Christopher Bentley[SUP] 2 [/SUP], Umayr Amin[SUP] 2 [/SUP], Azar T Jadir[SUP] 2 [/SUP], Samuel Hulme[SUP] 2 [/SUP], Morenike Ayodel[SUP] 2 [/SUP], Alexander C Dowell[SUP] 2 [/SUP], Hayden Pearce[SUP] 2 [/SUP], Jianmin Zuo[SUP] 2 [/SUP], Sandra Margielewska-Davies[SUP] 2 [/SUP], Kriti Verma[SUP] 2 [/SUP], Samantha Nicol[SUP] 2 [/SUP], Jusnara Begum[SUP] 2 [/SUP], Elizabeth Jinks[SUP] 2 [/SUP], Elif Tut[SUP] 2 [/SUP], Rachel Bruton[SUP] 2 [/SUP], Maria Krutikov[SUP] 3 [/SUP], Madhumita Shrotri[SUP] 3 [/SUP], Rebecca Giddings[SUP] 3 [/SUP], Borscha Azmi[SUP] 3 [/SUP], Chris Fuller[SUP] 3 [/SUP], Aidan Irwin-Singer[SUP] 4 [/SUP], Andrew Hayward[SUP] 5 [/SUP], Andrew Copas[SUP] 6 [/SUP], Laura Shallcross[SUP] 3 [/SUP], Paul Moss[SUP] 7 [/SUP]
Affiliations
- PMID: 37118449
- DOI: 10.1038/s43587-022-00224-w
We studied humoral and cellular immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 152 long-term care facility staff and 124 residents over a prospective 4-month period shortly after the first wave of infection in England. We show that residents of long-term care facilities developed high and stable levels of antibodies against spike protein and receptor-binding domain. Nucleocapsid-specific responses were also elevated but waned over time. Antibodies showed stable and equivalent levels of functional inhibition against spike-angiotensin-converting enzyme 2 binding in all age groups with comparable activity against viral variants of concern. SARS-CoV-2 seropositive donors showed high levels of antibodies to other beta-coronaviruses but serostatus did not impact humoral immunity to influenza or other respiratory syncytial viruses. SARS-CoV-2-specific cellular responses were similar across all ages but virus-specific populations showed elevated levels of activation in older donors. Thus, survivors of SARS-CoV-2 infection show a robust and stable immunity against the virus that does not negatively impact responses to other seasonal viruses.