Giuseppe
Emeritus
Influenza Immunization in Pregnancy -- Antibody Responses in Mothers and Infants (N Engl J Med., Correspondence, Extract, Edited.)
[Source: NEJM.org, Full PDF Document (LINK). Extract, Edited.]
Influenza Immunization in Pregnancy ? Antibody Responses in Mothers and Infants
To the Editor:
Though the use of seasonal trivalent inactivated influenza vaccines is recommended in pregnancy, there are few data on the immunogenicity of current vaccine formulations in pregnant women or on the duration of passive protection in their infants.1 We present antibody data for mothers and infants from a prospective, randomized, controlled trial of influenza vaccine in pregnant women,2 the Mother'sGift project.
In brief, 340 Bangladeshi women in the third trimester of pregnancy were randomly assigned to receive either a current commercial trivalent inactivated influenza vaccine (with these mothers and their infants called vaccinees) or a control (23-valent pneumococcal polysaccharide) vaccine (with these mothers and their infants called controls). Serum samples were obtained from 311 mothers before immunization and at delivery and from 292 infants at birth (cord-serum samples) and at 10 and 20 to 26 weeks later. The samples were tested with the use of hemagglutination-inhibition assays for the three virus subtypes present in the influenza vaccine: A/New Caledonia (H1N1), A/Fujian (H3N2), and B/Hong Kong (see the Supplementary Appendix, available with the full text of this letter at NEJM.org).
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[Source: NEJM.org, Full PDF Document (LINK). Extract, Edited.]
Influenza Immunization in Pregnancy ? Antibody Responses in Mothers and Infants
To the Editor:
Though the use of seasonal trivalent inactivated influenza vaccines is recommended in pregnancy, there are few data on the immunogenicity of current vaccine formulations in pregnant women or on the duration of passive protection in their infants.1 We present antibody data for mothers and infants from a prospective, randomized, controlled trial of influenza vaccine in pregnant women,2 the Mother'sGift project.
In brief, 340 Bangladeshi women in the third trimester of pregnancy were randomly assigned to receive either a current commercial trivalent inactivated influenza vaccine (with these mothers and their infants called vaccinees) or a control (23-valent pneumococcal polysaccharide) vaccine (with these mothers and their infants called controls). Serum samples were obtained from 311 mothers before immunization and at delivery and from 292 infants at birth (cord-serum samples) and at 10 and 20 to 26 weeks later. The samples were tested with the use of hemagglutination-inhibition assays for the three virus subtypes present in the influenza vaccine: A/New Caledonia (H1N1), A/Fujian (H3N2), and B/Hong Kong (see the Supplementary Appendix, available with the full text of this letter at NEJM.org).
(...)
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