N Engl J Med. Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus

[Giuseppe]

Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus (N Engl J Med., 1st paragraph, edited)


[Source: New England Journal of Medicine, full free text: <cite cite="http://www.nejm.org/doi/full/10.1056/NEJMc1003749?query=TOC">Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus ? NEJM</cite>. 1st paragraph, edited.]

Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus

N Engl J Med 2010; 363:1381-1382
September 30, 2010


To the Editor:

Since the outbreak of influenza A (H1N1) virus pandemic, almost 300 cases of infection with an oseltamivir-resistant influenza virus have been reported to the World Health Organization as of June 2010.1 These strains typically contain a single histidine-to-tyrosine substitution at position 275 (H275Y) of the viral neuraminidase, but they remain susceptible to zanamivir. Successful clearance of an oseltamivir-resistant virus with zanamivir, the other approved neuraminidase inhibitor, has been reported.2 We report the emergence of a pandemic influenza virus in a patient treated with neuraminidase inhibitors, with a novel resistance pattern that conferred resistance to oseltamivir, zanamivir, and peramivir.

(...)
-
------<cite cite="http://www.nejm.org/doi/full/10.1056/NEJMc1003749?query=TOC"></cite>

 

[Giuseppe]

Re: N Engl J Med. Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus

H1N1 can mutate in weak patients


[Source: Straits Times, View Original Article. 9/30/10.]

BOSTON - PATIENTS with suppressed immune systems can quickly develop H1N1 flu infections that resist all known drugs, doctors in the Netherlands reported on Wednesday. The case of a 5-year-old leukemia patient who died from swine flu after the virus mutated in his body showed that people with weakened immune systems may be at greater risk of developing dangerous drug-resistant infections, and illustrated the risks of using current drugs to treat these patients, the researchers said.
-
------