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Mystery of the pandemic flu virus of 1918 solved by University of Arizona researchers

tetano

Editor, Senior Moderator
University of Arizona researcher Michael Worobey and his team have discovered the key to understanding influenza pandemics may lie in previous flu exposure during childhood
A study led by Michael Worobey at the University of Arizona in Tucson provides the most conclusive answers yet to two of the world's foremost biomedical mysteries of the past century: the origin of the 1918 pandemic flu virus and its unusual severity, which resulted in a death toll of approximately 50 million people.

Worobey's paper on the flu, to be published in the early edition of the Proceedings of the National Academy of Sciences (PNAS) on April 28, not only sheds light on the devastating 1918 pandemic, but also suggests that the types of flu viruses to which people were exposed during childhood may predict how susceptible they are to future strains, which could inform vaccination strategies and pandemic prevention and preparedness.

"Ever since the great flu pandemic of 1918, it has been a mystery where that virus came from and why it was so severe, and in particular, why it killed young adults in the prime of life," said Worobey, a professor in the UA Department of Ecology and Evolutionary Biology. "It has been a huge question what the ingredients for that calamity were, and whether we should expect the same thing to happen tomorrow, or whether there was something special about that situation."

http://www.eurekalert.org/pub_releases/2014-04/uoa-mot042414.php
 
Re: Mystery of the pandemic flu virus of 1918 solved by University of Arizona researchers

headline makers don't understand complicated flu papers

("solved" is not what the paper says ...
> we hypothesize that ...


i.e. I'm skeptical that H1 was around since 1901 as they suggest.
I think that's not conform with the age-pattern in 1918.

There may have been H1 in mammals, even humans,
but was it seasonal, widespread ??

No mention of the lack of reports of seasonal flu
in 1870-1889 in e.g. England
So what made the Brits aged 48 in 1918 resist better
than those aged 30 ?

I'm also skeptical that mutation rates were different in humans,birds,swine
but I said that before afair, wasn't it when Worobey explained how he got
that idea from watching children or such ?
 
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