tetano
Editor, Senior Moderator
Emerg Infect Dis. 2012 Jan;18(1):109-12. doi: 10.3201/eid1801.111079.
Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses.
Hurt AC, Leang SK, Speers DJ, Barr IG, Maurer-Stroh S.
Abstract
Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
PMID:
22260817
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22260817
Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses.
Hurt AC, Leang SK, Speers DJ, Barr IG, Maurer-Stroh S.
Abstract
Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
PMID:
22260817
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22260817