-
FluTrackers.com Inc. does not provide medical advice. Information on this web site is collected from various internet resources, and the FluTrackers board of directors makes no warranty to the safety, efficacy, correctness or completeness of the information posted on this site by any author or poster. The information collated here is for instructional and/or discussion purposes only and is NOT intended to diagnose or treat any disease, illness, or other medical condition. Every individual reader or poster should seek advice from their personal physician/healthcare practitioner before considering or using any interventions that are discussed on this website. By continuing to access this website you agree to consult your personal physican before using any interventions posted on this website, and you agree to hold harmless FluTrackers.com Inc., the board of directors, the members, and all authors and posters for any effects from use of any medication, supplement, vitamin or other substance, device, intervention, etc. mentioned in posts on this website, or other internet venues referenced in posts on this website. -
We are not asking for any donations. Do not donate to any entity who says they are raising funds for us.
Mutating to a less virulent strain
- Thread starter DB
- Start date
sharon sanders
Editor-in-Chief & President
Re: Mutating to a less virulent strain
A lot, I think........?
A lot, I think........?
AlaskaDenise
In Memoriam
Re: Mutating to a less virulent strain
Decreasing virulence may be determined by things other than random mutations. It may fall under "Restriction of cytopathogenic effects to allow for an approptiate balance between viral replication and control by the host." (from here) That is - the normal learning curve.
It's my understanding that the "virulence" mutations are immune evasion (pos. 92 in NS1 & being a novel less-human antigen) and increased cleavability (multiple amino acids in H5N1, but it was NA mutation in 1918 H1N1)
It could "fade out" from a stronger influenza....as happened in the past.
I'll never be completely worry-free about influenza again, knowing that there will always be another potentially-pandemic influenza "in the oven."
.
Decreasing virulence may be determined by things other than random mutations. It may fall under "Restriction of cytopathogenic effects to allow for an approptiate balance between viral replication and control by the host." (from here) That is - the normal learning curve.
It's my understanding that the "virulence" mutations are immune evasion (pos. 92 in NS1 & being a novel less-human antigen) and increased cleavability (multiple amino acids in H5N1, but it was NA mutation in 1918 H1N1)
It could "fade out" from a stronger influenza....as happened in the past.
I'll never be completely worry-free about influenza again, knowing that there will always be another potentially-pandemic influenza "in the oven."
.
Last edited:
KC
Moderator
Re: Mutating to a less virulent strain
AlaskaDenise, I will always be more informed on emerging viruses in the future also. I am concerned that we may focus on one and miss something that is emerging so quickly that we miss the "silver bullet" coming at us.
I have found (over the last 6 months) that many viruses that are emerging can, and do in some cases produce the "cytokine storm", have chemokine reactions, or can cause severe problems such as encephalitis and meningitis. Some are spreading rapidly and increasing their virulence such as Chik and West Nile.
Over the last week, I have read several papers and visited many websites on emerging viruses. Emerging influenza scares me the most, but vector borne viruses are right behind them. What is really scary is the thought that so many viruses that have been under control for years are re-emerging with such voracity.
With vector borne viruses, the vector list and host species are expanding rapidly. Viruses are mutating so that they can be carried by multiple vectors (ie- mosquitoes, ticks, deer flies, and horse flies). With an increase of vector species, there is also an increase in intermediary and dead end hosts.
I guess the only way to really feel safe (safer) is to keep informed and keep prepared.
AlaskaDenise said:
AlaskaDenise, I will always be more informed on emerging viruses in the future also. I am concerned that we may focus on one and miss something that is emerging so quickly that we miss the "silver bullet" coming at us.
I have found (over the last 6 months) that many viruses that are emerging can, and do in some cases produce the "cytokine storm", have chemokine reactions, or can cause severe problems such as encephalitis and meningitis. Some are spreading rapidly and increasing their virulence such as Chik and West Nile.
Over the last week, I have read several papers and visited many websites on emerging viruses. Emerging influenza scares me the most, but vector borne viruses are right behind them. What is really scary is the thought that so many viruses that have been under control for years are re-emerging with such voracity.
With vector borne viruses, the vector list and host species are expanding rapidly. Viruses are mutating so that they can be carried by multiple vectors (ie- mosquitoes, ticks, deer flies, and horse flies). With an increase of vector species, there is also an increase in intermediary and dead end hosts.
I guess the only way to really feel safe (safer) is to keep informed and keep prepared.
Last edited:
AlaskaDenise
In Memoriam
Re: Mutating to a less virulent strain
Time for some serious reality checks. The easy-livin' party is about to get a few rules ... if you want to live to party another day.
If we're not willing to make some sacrifices, then... the old adage, "nothing's certain but death and taxes" - the death part may start occuring with a frequency more resembing that of taxes.
.
Time for some serious reality checks. The easy-livin' party is about to get a few rules ... if you want to live to party another day.
If we're not willing to make some sacrifices, then... the old adage, "nothing's certain but death and taxes" - the death part may start occuring with a frequency more resembing that of taxes.
.
AlaskaDenise
In Memoriam
Re: Mutating to a less virulent strain
additional virulence factors relative to ease of secondary bacterial lung infections.
After doing some reading about the mechanisms to secondary bacterial infections, I discovered that there is some unusal action attributed to the Neuraminidase, but they specifically mention the a2,6 binding action - see post #4 in thread about cases in east Russia.
.
additional virulence factors relative to ease of secondary bacterial lung infections.
After doing some reading about the mechanisms to secondary bacterial infections, I discovered that there is some unusal action attributed to the Neuraminidase, but they specifically mention the a2,6 binding action - see post #4 in thread about cases in east Russia.
.