tetano
Editor, Senior Moderator
Viruses. 2016 Sep 29;8(10). pii: E269.
[h=1]Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction.[/h] S?derholm S[SUP]1,[/SUP][SUP]2[/SUP], Fu Y[SUP]3[/SUP], Gaelings L[SUP]4[/SUP], Belanov S[SUP]5[/SUP], Yetukuri L[SUP]6[/SUP], Berlinkov M[SUP]7[/SUP], Cheltsov AV[SUP]8[/SUP], Anders S[SUP]9[/SUP], Aittokallio T[SUP]10,[/SUP][SUP]11[/SUP], Nyman TA[SUP]12[/SUP], Matikainen S[SUP]13,[/SUP][SUP]14[/SUP], Kainov DE[SUP]15[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV-host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 199 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the 665 remains unknown. Studying anti-influenza efficacy and immuno/neuro-modulating properties of these compounds and their combinations as well as potential viral and host resistance to them may lead to the discovery of novel modulators of IAV-host interactions, which might be more effective than the currently available anti-influenza therapeutics.
[h=4]KEYWORDS:[/h] antiviral agent; genomics; influenza virus; metabolomics; phosphoproteomics; proteomics; transcriptomics; virtual ligand screening
PMID: 27690086 DOI: 10.3390/v8100269
[PubMed - as supplied by publisher] Free full text
[h=1]Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction.[/h] S?derholm S[SUP]1,[/SUP][SUP]2[/SUP], Fu Y[SUP]3[/SUP], Gaelings L[SUP]4[/SUP], Belanov S[SUP]5[/SUP], Yetukuri L[SUP]6[/SUP], Berlinkov M[SUP]7[/SUP], Cheltsov AV[SUP]8[/SUP], Anders S[SUP]9[/SUP], Aittokallio T[SUP]10,[/SUP][SUP]11[/SUP], Nyman TA[SUP]12[/SUP], Matikainen S[SUP]13,[/SUP][SUP]14[/SUP], Kainov DE[SUP]15[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV-host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 199 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the 665 remains unknown. Studying anti-influenza efficacy and immuno/neuro-modulating properties of these compounds and their combinations as well as potential viral and host resistance to them may lead to the discovery of novel modulators of IAV-host interactions, which might be more effective than the currently available anti-influenza therapeutics.
[h=4]KEYWORDS:[/h] antiviral agent; genomics; influenza virus; metabolomics; phosphoproteomics; proteomics; transcriptomics; virtual ligand screening
PMID: 27690086 DOI: 10.3390/v8100269
[PubMed - as supplied by publisher] Free full text