tetano
Editor, Senior Moderator
Mult Scler Relat Disord
. 2021 Apr 11;52:102947.
doi: 10.1016/j.msard.2021.102947. Online ahead of print.
Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study
Mahdi Barzegar[SUP] 1 [/SUP], Saeed Vaheb[SUP] 2 [/SUP], Omid Mirmosayyeb[SUP] 1 [/SUP], Alireza Afshari-Safavi[SUP] 3 [/SUP], Nasim Nehzat[SUP] 4 [/SUP], Vahid Shaygannejad[SUP] 5 [/SUP]
Affiliations
Abstract
The effect of coronavirus disease (COVID-19) on the risk of relapse in multiple sclerosis (MS) have been unknown. In this retrospective study of 41 relapsing-remitting MS patients, number of relapses in pre-defined at risk-period (ARP) was compared with the previous two years. During the previous two years, a total of 32 attacks was reported, which 5 (15.6%) were during the at-risk period. After adjusting for age and sex, there was an increased risk of attack during ARP compared to the previous two years (RR: 2.566, 95%CI: 1.075-6.124, P=0.034). Our preliminary study suggested that COVID-19 can trigger exacerbation of MS.
Keywords: Coronavirus; Exacerbation; Infection; Multiple sclerosis; Relapse.
. 2021 Apr 11;52:102947.
doi: 10.1016/j.msard.2021.102947. Online ahead of print.
Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study
Mahdi Barzegar[SUP] 1 [/SUP], Saeed Vaheb[SUP] 2 [/SUP], Omid Mirmosayyeb[SUP] 1 [/SUP], Alireza Afshari-Safavi[SUP] 3 [/SUP], Nasim Nehzat[SUP] 4 [/SUP], Vahid Shaygannejad[SUP] 5 [/SUP]
Affiliations
- PMID: 33979771
- PMCID: PMC8036166
- DOI: 10.1016/j.msard.2021.102947
Abstract
The effect of coronavirus disease (COVID-19) on the risk of relapse in multiple sclerosis (MS) have been unknown. In this retrospective study of 41 relapsing-remitting MS patients, number of relapses in pre-defined at risk-period (ARP) was compared with the previous two years. During the previous two years, a total of 32 attacks was reported, which 5 (15.6%) were during the at-risk period. After adjusting for age and sex, there was an increased risk of attack during ARP compared to the previous two years (RR: 2.566, 95%CI: 1.075-6.124, P=0.034). Our preliminary study suggested that COVID-19 can trigger exacerbation of MS.
Keywords: Coronavirus; Exacerbation; Infection; Multiple sclerosis; Relapse.