tetano
Editor, Senior Moderator
Mult Scler
. 2023 Feb 25;13524585231154780.
doi: 10.1177/13524585231154780. Online ahead of print.
Acute central nervous system inflammation following COVID-19 vaccination: An observational cohort study
Sydney Lee[SUP] 1 [/SUP], Alexandra Muccilli[SUP] 2 [/SUP], Raphael Schneider[SUP] 3 [/SUP], Daniel Selchen[SUP] 2 [/SUP], Kristen M Krysko[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Reports suggest a potential association between coronavirus disease 2019 (COVID-19) vaccines and acute central nervous system (CNS) inflammation.
Objective: The main objective of this study is to describe features of acute CNS inflammation following COVID-19 vaccination.
Methods: A retrospective observational cohort study was performed at the BARLO MS Centre in Toronto, Canada. Clinicians reported acute CNS inflammatory events within 60 days after a COVID-19 vaccine from March 2021 to August 2022. Clinical characteristics were evaluated.
Results: Thirty-eight patients (median age 39 (range: 20-82) years; 60.5% female) presented within 0-55 (median 15) days of a receiving a COVID-19 vaccine and were diagnosed with relapsing remitting multiple sclerosis (MS) (n = 16), post-vaccine transverse myelitis (n = 7), clinically isolated syndrome (n = 5), MS relapse (n = 4), tumefactive demyelination (n = 2), myelin oligodendrocyte glycoprotein antibody disease (n = 1), neuromyelitis optica spectrum disorder (n = 1), chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (n = 1) and primary autoimmune cerebellar ataxia (n = 1). Twenty-two received acute treatment and 21 started disease-modifying therapy. Sixteen received subsequent COVID-19 vaccination, of which 87.5% had no new or worsening neurological symptoms.
Conclusion: To our knowledge, this is the largest study describing acute CNS inflammation after COVID-19 vaccination. We could not determine whether the number of inflammatory events was higher than expected.
Keywords: COVID-19; central nervous system; demyelinating diseases; multiple sclerosis; neuroinflammatory diseases; vaccination.
. 2023 Feb 25;13524585231154780.
doi: 10.1177/13524585231154780. Online ahead of print.
Acute central nervous system inflammation following COVID-19 vaccination: An observational cohort study
Sydney Lee[SUP] 1 [/SUP], Alexandra Muccilli[SUP] 2 [/SUP], Raphael Schneider[SUP] 3 [/SUP], Daniel Selchen[SUP] 2 [/SUP], Kristen M Krysko[SUP] 3 [/SUP]
Affiliations
- PMID: 36840605
- DOI: 10.1177/13524585231154780
Abstract
Background: Reports suggest a potential association between coronavirus disease 2019 (COVID-19) vaccines and acute central nervous system (CNS) inflammation.
Objective: The main objective of this study is to describe features of acute CNS inflammation following COVID-19 vaccination.
Methods: A retrospective observational cohort study was performed at the BARLO MS Centre in Toronto, Canada. Clinicians reported acute CNS inflammatory events within 60 days after a COVID-19 vaccine from March 2021 to August 2022. Clinical characteristics were evaluated.
Results: Thirty-eight patients (median age 39 (range: 20-82) years; 60.5% female) presented within 0-55 (median 15) days of a receiving a COVID-19 vaccine and were diagnosed with relapsing remitting multiple sclerosis (MS) (n = 16), post-vaccine transverse myelitis (n = 7), clinically isolated syndrome (n = 5), MS relapse (n = 4), tumefactive demyelination (n = 2), myelin oligodendrocyte glycoprotein antibody disease (n = 1), neuromyelitis optica spectrum disorder (n = 1), chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (n = 1) and primary autoimmune cerebellar ataxia (n = 1). Twenty-two received acute treatment and 21 started disease-modifying therapy. Sixteen received subsequent COVID-19 vaccination, of which 87.5% had no new or worsening neurological symptoms.
Conclusion: To our knowledge, this is the largest study describing acute CNS inflammation after COVID-19 vaccination. We could not determine whether the number of inflammatory events was higher than expected.
Keywords: COVID-19; central nervous system; demyelinating diseases; multiple sclerosis; neuroinflammatory diseases; vaccination.